Adjusted regression trend test for a multicenter clinical trial

Biometrics

Volumn 55, Issue 2, 1999, Pages 460-462

  Quan, Hui ^a   Capizzi, Thomas ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Closed test procedure; Ordered alternative; P value adjustment; Two way design

Indexed keywords

ERROR ANALYSIS; REGRESSION ANALYSIS;

CLOSED TEST PROCEDURE; MULTI-CENTER CLINICAL TRIALS; ORDERED ALTERNATIVES; P-VALUE ADJUSTMENT; P-VALUES; STEP DOWN; TEST PROCEDURES; TREND TESTS; TWO WAYS; TWO-WAY DESIGN;

MEDICAL APPLICATIONS;

ALENDRONIC ACID; PHOSPHONIC ACID DERIVATIVE;

ARTICLE; BONE DENSITY; CONTROLLED STUDY; COVARIANCE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; REGRESSION ANALYSIS; STATISTICAL ANALYSIS; STATISTICAL MODEL; TECHNIQUE;

EID: 0033004332     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0006-341X.1999.00460.x     Document Type: Article

References (8)

1. Capizzi, T., Survill, T. T., Heyse, J. F., and Malani, H. (1992). An empirical and simulated comparison of some tests for detecting progressiveness of response with increasing doses of a compound. Biometrical Journal 34, 275-289.
2. Marcus, R., Peritz, E., and Gabriel, K. R. (1976). On closed testing procedures with special reference to ordered analysis of variance. Biometrika 63, 655-660.
3. McCann, M. and Edwards, D. (1996). A path length inequality for the multivariate-t distribution, with applications to multiple comparisons. Journal of the American Statistical Association 91, 211-216.
4. Quan, H. and Capizzi, T. (1996). Adjusted trend test for a multicenter clinical trial. Proceedings of the Biopharmaceutical Section of the American Statistical Association 197-202.
5. Robertson, T., Wright, F. T., and Dykstra, R. L. (1988). Order Restricted Statistical Inference. New York: Wiley.
6. Shirley, E. A. C. (1979). The comparison of treatment with control group means in toxicological studies. Applied Statistics 28, 144-151.
7. Shirley, E. A. C. (1985). The value of specialized tests in studies where ordered group means are expected. Statistics in Medicine 4, 489-496.
8. Tukey, J. W., Ciminera, J. L., and Heyse, J. F. (1985). Testing the statistical certainty of a response to increasing doses of a drug. Biometrics 41, 295-301.