Genetic determinants of folate status in central Bohemia

Physiological Research

Volumn 54, Issue 3, 2005, Pages 295-303

  Vesela K ^a,b   Pavlikova M ^c   Janosikova B ^a   Andel M ^b   Zvarova J ^c   Hyanek J ^d   Kožich, Viktor ^a  

^a Charles University in Prague and General University Hospital in Prague   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF COMPUTER SCIENCE   (Czech Republic)

^d NA HOMOLCE HOSPITAL   (Czech Republic)

Author keywords

5,10 Methylenetetrahydrofolate reductase; Folate hydrolase 1; Folates; Polymorphism; Reduced folate carrier

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLATE RECEPTOR; FOLIC ACID; GAMMA GLUTAMYL HYDROLASE; REDUCED FOLATE CARRIER;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CZECH REPUBLIC; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HUMAN; MAJOR CLINICAL STUDY; MALE;

ARYL HYDROCARBON HYDROXYLASES; CZECH REPUBLIC; DIETARY SUPPLEMENTS; DNA MUTATIONAL ANALYSIS; FEMALE; FOLIC ACID; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; LUNG NEOPLASMS; MALE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+); MIDDLE AGED; POLYMORPHISM, GENETIC; RISK ASSESSMENT; RISK FACTORS;

EID: 21844441674     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. ASHFIELD-WATT PA, PULLIN CH, WHITING JM, CLARK ZE, MOAT SJ, NEWCOMBE RG, BURR ML, LEWIS MJ, POWERS HJ, McDOWELL IF: Methylenetetrahydrofolate reductase 677C→T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial. Am J Clin Nutr 76: 180-186, 2002.
2. BAGLEY PJ, SELHUB J: A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 95: 13217-13220, 1998.
3. BENES P, KAŇKOVÁ K, MUŽÍK J, GROCH L, BENEDÍK J, ELBL L, IZAKOVIČOVÁ-HOLLA L, VAŠKŮ A, ZNOJIL V, VÁCHA J: Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population. Mol Genet Metab 73: 188-195, 2001.
4. BRATTSTROM L, WILCKEN DE, OHRVIK J, BRUDIN L: Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 98: 2520-2526, 1998.
5. CHANGO A, EMERY-FILLON N, DE COURCY GP, LAMBERT D, PFISTER M, ROSENBLATT DS, NICOLAS JP: A polymorphism (80G→A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab 70: 310-315, 2000.
6. COOK RJ: Folate Metabolism. In: Homocysteine in Health and Disease. R CARMEL, DW JACOBSEN (eds), Cambridge University Press, Cambridge, 2001, pp 113-134.
7. DE BREE A, VERSCHUREN WM, BJORKE-MONSEN AL, VAN DER PUT NM, HEIL SG, TRUBELS FJ, BLOM HJ: Effect of the methylenetetrahydrofolate reductase 677C→T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr 77: 687-693, 2003.
8. DEVLIN AM, LING EH, PEERSON JM, FERNANDO S, CLARKE R, SMITH AD, HALSTED CH: Glutamate carboxypeptidase II: a polymorphism associated with lower levels of serum folate and hyperhomocysteinemia. Hum Mol Genet 9: 2837-2844, 2000.
9. EICHHOLZER M, LUTHY J, MOSER U, FOWLER B: Folate and the risk of colorectal, breast and cervix cancer: the epidemiological evidence. Swiss Med Wkly 131: 539-549, 2001.
10. FINNELL RH, SPIEGELSTEIN O, WLODARCZYK B, TRIPLETT A, POGRIBNY IP, MELNYK S, JAMES JS: DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. J Nutr 132: 2457S-24618, 2002.
11. FODINGER M, DIERKES J, SKOUPY S, ROHRER C, HAGEN W, PUTTINGER H, HAUSER AC, VYCHYTIL A, SUNDER-PLASSMANN G: Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients. J Am Soc Nephrol 14: 1314-1319, 2003.
12. FOWLER B: The folate cycle and disease in humans. Kidney Int 59 (Suppl 78): S221-S229, 2001.
13. FROSST P, BLOM HJ, MILOS R, GOYETTE P, SHEPPARD CA, MATTHEWS RG, BOERS GJ, DEN HEIJER M, KLUIJTMANS LA, VAN DEN HEUVEL LP, ROZEN R: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10: 111-113, 1995.
14. GANJI V, KAFAI MR: Demographic, health, lifestyle, and blood vitamin determinants of serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey, 1988-1994. Am J Clin Nutr 77: 826-833, 2003.
15. HALSTED CH, VILLANUEVA JA, DEVLIN AM, CHANDLER CJ: Metabolic interactions of alcohol and folate. J Nutr 132: 2367S-2372S, 2002.
16. HANSEN DK, STRECK RD, ANTONY AC: Antisense modulation of the coding or regulatory sequence of the folate receptor (folate binding protein-1) in mouse embryos leads to neural tube defects. Birth Defects Res A Clin Mol Teratol 67: 475-487, 2003.
17. JANOŠÍKOVÁ B, PAVLÍKOVÁ M, KOCMANOVÁ D, VİTOVÁ A, VESELÁ K, KRUPKOVÁ L, KAHLEOVÁ R, KRIJT J, KRAML P, HYÁNEK J, ZVÁROVÁ J, ANDĚL M, KOŽICH V: Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease. Mol Genet Metab 79: 167-175, 2003.
18. KLERK M, VERHOEF P, CLARKE R, BLOM HJ, KOK FJ, SCHOUTEN EG: MTHFR 677C→T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 288: 2023-2031, 2002.
19. KRIJT J, VACKOVÁ M, KOZTCH V: Measurement of homocysteine and other aminothiols in plasma: advantages of using tris(2-carboxyethyl)phosphine as reductant compared with tri-n-butylphosphine. Clin Chem 47: 1821-1828, 2001.
20. LINDEMAN RD, ROMERO LJ, YAU CL, KOEHLER KM, BAUMGARTNER RN, CARRY PJ: Serum homocysteine concentrations and their relation to serum folate and vitamin B12 concentrations and coronary artery disease prevalence in an urban, bi-ethnic community. Ethn Dis 13: 178-185, 2003.
21. McDONALD SD, FERGUSON S, TAM L, LOUGHEED J, WALKER MC: The prevention of congenital anomalies with periconceptional folic acid supplementation. J Obstet Gynaecol Can 25: 115-121, 2003.
22. MOLLOY AM, MILLS JL, KIRKE PN, WHITEHEAD AS, WEIR DG, SCOTT JM: Whole-blood folate values in subjects with different methylenetetrahydro folate reductase genotypes: differences between the radioassay and microbiological assays. Clin Chem 44: 186-188, 1998.
23. MORIN I, DEVLIN AM, LECLERC D, SABBAGHIAN N, HALSTED CH, FINNELL R, ROZEN R: Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk. Mol Genet Metab 79: 197-200, 2003.
24. NAKANO E, TAYLOR CJ, CHADA L, McGAW J, POWERS HJ: Hyperhomocystinemia in children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 37: 586-590, 2003.
25. NELEN WL, BLOM HJ, THOMAS CM, STEEGERS EA, BOERS GH, ESKES TK: Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. J Nutr 128: 1336-1341, 1998.
26. QUINLIVAN EP, GREGORY JF: Effect of food fortification on folic acid intake in the United States. Am J Clin Nutr 77: 221-225, 2003.
27. 6 from diet and supplements in relation to risk of coronary heart disease among women. JAMA 279: 359-364, 1998.
28. ROZEN R: Polymorphisms of folate and cobalamin metabolism. In: Homocysteine in Health and Disease. DWJ RALPH CARMEL (ed), Cambridge Univerzity Pres, Cambridge, 2001, pp 259-269.
29. RUPRICH J: Folic acid. /in Czech) In: Spotřební koś potravin pro ČR. J RUPRICH (eds), Státní zdravotni ústav, Praha, 1997, pp 52-61.
30. SELHUB J, MILLER JW: The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 55: 131-138, 1992.
31. SHANE B: Folate metabolism. In: Folic Acid Metabolism in Health and Disesase. M PICCIANO, E STOKSTAD, J GREGORY (eds), Wiley-Liss, New York, 1990, pp 65-78.
32. UELAND PM, HUSTAD S, SCHNEEDE J, REFSUM H, VOLLSET SE: Biological and clinical implications of the MTHFR C677T polymorphism. Trends Pharmacol Sci 22: 195-201, 2001.
33. VAN DER PUT NM, STEEGERS-THEUNISSEN RP, FROSST P, TRUBELS FJ, ESKES TK, VAN DEN HEUVEL LP, MARIMAN EC, DEN HEYER M, ROZEN R, BLOM HJ: Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346: 1070-1071, 1995.
34. VAN DER PUT NM, GABREELS F, STEVENS EM, SMEITINK JA, TRUBELS FJ, ESKES TK, VAN DEN HEUVEL LP, BLOM HJ: A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Am J Hum Genet 62: 1044-1051, 1998.
35. VARGAS-MARTINEZ C, ORDOVAS JM, WILSON PW, SELHUB J: The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort. J Nutr 132: 1176-1179, 2002.
36. VOUTILAINEN S, RISSANEN TH, VIRTANEN J, LAKKA TA, SALONEN JT: Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 103: 2674-2680, 2001.
37. WEISBERG I, TRAN P, CHRISTENSEN B, SIBANI S, ROZEN R: A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab 64: 169-172, 1998.
38. WINKELMAYER WC, EBERLE C, SUNDER-PLASSMANN G, FODINGER M: Effects of the glutamate carboxypeptidase IJ (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients. Kidney Int 63: 2280-2285, 2003.