Alteration of the DNA binding domain disrupts distinct functions of the C. elegans Pax protein EGL-38

Mechanisms of Development

Volumn 122, Issue 7-8, 2005, Pages 887-899

  Zhang, Guojuan ^a   Sleiman, Sama F ^a   Tseng, Rong Jeng ^a   Rajakumar, Vandana ^a   Wang, Xiaodong ^a   Chamberlin, Helen M ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

DNA binding; Pax transcription factor; Transactivation; Transcriptional control

Indexed keywords

AMINO ACID; CAENORHABDITIS ELEGANS PROTEIN; MUTANT PROTEIN; PROTEIN EGL 38; TRANSCRIPTION FACTOR PAX2; TRANSCRIPTION FACTOR PAX5; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CAENORHABDITIS ELEGANS; DNA RESPONSIVE ELEMENT; GENE MUTATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN TARGETING;

ALLELES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BINDING SITES; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DNA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 21844435479     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mod.2005.04.005     Document Type: Article

References (39)

1. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smith, and K. Struhl Current Protocols in Molecular Biology 2000 Wiley New York, NY
2. D. Bopp, M. Burri, S. Baumgartner, G. Frigerio, and M. Noll Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila Cell 47 1986 1033 1040
3. P.D. Brophy, K.M. Lang, and G.R. Dressler The secreted frizzled related protein 2 (SFRP2) gene is a target of the Pax2 transcription factor J. Biol. Chem. 278 2003 52401 52405
4. H.M. Chamberlin, R.E. Palmer, A.P. Newman, P.W. Sternberg, D.L. Baillie, and J.H. Thomas The PAX gene egl-38 mediates developmental patterning in Caenorhabditis elegans Development 124 1997 3919 3928
5. H.M. Chamberlin, K.B. Brown, P.W. Sternberg, and J.H. Thomas Characterization of seven genes affecting Caenorhabditis elegans hindgut development Genetics 153 1999 731 742
6. C. Chang, A.P. Newman, and P.W. Sternberg Reciprocal EGF signaling back to the uterus from the induced C. elegans vulva coordinates morphogenesis of epithelia Curr. Biol. 9 1999 237 246
7. N. Chi, and J.A. Epstein Getting your Pax straight: Pax proteins in development and disease Trends. Genet. 18 2002 41 47
8. A.D. Chisholm, and H.R. Horvitz Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3 Nature 377 1995 52 55
9. T. Czerny, G. Schaffner, and M. Busslinger DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site Genes. Dev. 7 1993 2048 2061
10. A.L. DeStefano, L.A. Cupples, K.S. Arnos, J.H. Asher Jr., C.T. Baldwin, and S. Blanton Correlation between Waardenburg syndrome phenotype and genotype in a population of individuals with identified PAX3 mutations Human Genet. 102 1998 499 506
11. T. Di Palma, R. Nitsch, A. Mascia, L. Nitsch, R. Di Lauro, and M. Zannini The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription J. Biol. Chem. 278 2003 3395 3402
12. M.R. Eccles, L.J. Wallis, A.E. Fidler, N.K. Spurr, P.J. Goodfellow, and A.E. Reeve Expression of the PAX2 gene in human fetal kidney and Wilms' tumor Cell Growth. Differentiat. 3 1992 279 289
13. J. Epstein, J. Cai, T. Glaser, L. Jepeal, and R. Maas Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes J. Biol. Chem. 269 1994 8355 8361
14. D. Fitzsimmons, W. Hodsdon, W. Wheat, S.M. Maira, B. Wasylyk, and J. Hagman Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter Genes. Dev. 10 1996 2198 2211
15. D. Fitzsimmons, R. Lutz, W. Wheat, H.M. Chamberlin, and J. Hagman Highly conserved amino acids in Pax and Ets proteins are required for DNA binding and ternary complex assembly Nucl. Acids Res. 29 2001 4154 4165
16. T. Inoue, D.R. Sherwood, G. Aspock, J.A. Butler, B.P. Gupta, and M. Kirouac Gene expression markers for Caenorhabditis elegans vulval cells Gene Express. Patterns 2 2002 235 241
17. F. Jeanmougin, J.D. Thompson, M. Gouy, D.G. Higgins, and T.J. Gibson Multiple sequence alignment with Clustal X Trends Biochem. Sci. 23 1998 403 405
18. Z.X. Jin, H. Kishi, X.C. Wei, T. Matsuda, S. Saito, and A. Muraguchi Lymphoid enhancer-binding factor-1 binds and activates the recombination- activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells J. Immunol. 169 2002 3783 3792
19. A.D. Johnson, D. Fitzsimmons, J. Hagman, and H.M. Chamberlin EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development Development 128 2001 2857 2865
20. D. Jumlongras, J.Y. Lin, A. Chapra, C.E. Seidman, J.G. Seidman, R.L. Maas, and B.R. Olsen A novel missense mutation in the paired domain of PAX9 causes non-syndromic oligodontia Hum. Genet. 114 2004 242 249
21. S. Jun, and C. Desplan Cooperative interactions between paired domain and homeodomain Development 122 1996 2639 2650
22. S. Jun, R.V. Wallen, A. Goriely, B. Kalionis, and C. Desplan Lune/eye gone, a Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition Proceedings of the National Academy of Sciences of the United States of America 95 1998 13720 13725
23. Z. Kozmik, T. Czerny, and M. Busslinger Alternatively spliced insertions in the paired domain restrict the DNA sequence specificity of Pax6 and Pax8 Eur. Mol. Bio. Organ. J. 16 1997 6793 6803
24. M. Maduro, and D. Pilgrim Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system Genetics 141 1995 977 988
25. C.C. Mello, J.M. Kramer, D. Stinchcomb, and V. Ambros Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences Eur. Mol. Bio. Organ. J. 10 1991 3959 3970
26. G.A. Miranda, M. Villalvazo, Z. Galic, J. Alva, R. Abrines, and Y. Yates Combinatorial regulation of the murine RAG-2 promoter by Sp1 and distinct lymphocyte-specific transcription factors Mol. Immun. 38 2002 1151 1159
27. E.C. Roberts, R.W. Deed, T. Inoue, J.D. Norton, and A.D. Sharrocks Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding Mol. Cell. Biol. 21 2001 524 533
28. S.T. Sewell, G. Zhang, A. Uttam, and H.M. Chamberlin Developmental patterning in the Caenorhabditis elegans hindgut Dev. Biol. 262 2003 88 93
29. M. Sigvardsson, D.R. Clark, D. Fitzsimmons, M. Doyle, P. Akerblad, and T. Breslin Early B-cell factor, E2A, and Pax-5 cooperate to activate the early B cell-specific mb-1 promoter Mol. Cell. Biol. 22 2002 8539 8551
30. J.E. Sulston, and J. Hodgkin W.B. Wood The Nematode Caenorhabditis elegans 1988 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY 587 606
31. H.K. Tang, L.Y. Chao, and G.F. Saunders Functional analysis of paired box missense mutations in the PAX6 gene Hum. Mole. Gene. 6 1997 381 386
32. W. Thompson, E.C. Rouchka, and C.E. Lawrence Gibbs Recursive Sampler: finding transcription factor binding sites Nucl. Acids Res. 31 2003 3580 3585
33. C. Trent, N. Tsuing, and H.R. Horvitz Egg-laying defective mutants of the nematode Caenorhabditis elegans Genetics 104 1983 619 647
34. C. Vilain, C. Rydlewski, L. Duprez, C. Heinrichs, M. Abramowicz, and P. Malvaux Autosomal dominant transmission of congenital thyroid hypoplasia due to loss-of-function mutation of PAX8 J. Clin. Endocrinol. Metabol. 86 2001 234 238
35. X. Wang, and H.M. Chamberlin Multiple regulatory changes contribute to the evolution of the Caenorhabditis lin-48 ovo gene Genes. Deve. 16 2002 2345 2349
36. W. Wheat, D. Fitzsimmons, H. Lennox, S.R. Krautkramer, L.N. Gentile, L.P. McIntosh, and J. Hagman The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes Mol. Cell. Biol. 19 1999 2231 2241
37. W. Xu, M.A. Rould, S. Jun, C. Desplan, and C.O. Pabo Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations Cell 80 1995 639 650
38. H.E. Xu, M.A. Rould, W. Xu, J.A. Epstein, R.L. Maas, and C.O. Pabo Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding Genes. Dev. 13 1999 1263 1275
39. P.X. Xu, X. Zhang, S. Heaney, A. Yoon, A.M. Michelson, and R.L. Maas Regulation of Pax6 expression is conserved between mice and flies Development 126 1999 383 395