Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 15, 2005, Pages 3632-3636

  Ullman, Brett R ^a   Aja, Teresa ^a   Chen, Ning ^a   Diaz, Jose Luis ^a   Gu, Xin ^a   Herrmann, Julia ^a   Kalish, Vincent J ^a   Karanewsky, Donald S ^a   Kodandapani, Lalitha ^a   Krebs, Joseph J ^a   Linton, Steven D ^a   Meduna, Steven P ^a   Nalley, Kip ^a   Robinson, Edward D ^a   Roggo, Silvio P ^b   Sayers, Robert O ^a   Schmitz, Albert ^b   Ternansky, Robert J ^a   Tomaselli, Kevin J ^a   Wu, Joe C ^a  

^a PFIZER INC   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYLOXYACETYLVALYLASPARTIC ACID; BENZENE DERIVATIVE; CASPASE 3 INHIBITOR; CASPASE 6; CASPASE 8 INHIBITOR; CASPASE INHIBITOR; ENZYME INHIBITOR; ETHER DERIVATIVE; HETEROCYCLIC COMPOUND; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; ISOXAZOLE DERIVATIVE; KETONE DERIVATIVE; NAPHTHALENE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG EFFICACY; HUMAN; HUMAN CELL; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ASPARTIC ACID; CASPASES; CELL DEATH; CELLS, CULTURED; CYSTEINE PROTEINASE INHIBITORS; HETEROCYCLIC COMPOUNDS; KETONES; MICE; MODELS, BIOLOGICAL; NAPHTHOLS; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE;

EID: 21744459526     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.036     Document Type: Article

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