The endocannabinoid system and the regulation of the metabolism;Le système endocannabinoïde et la régulation du métabolisme

Revue Medicale de Bruxelles

Volumn 26, Issue 3, 2005, Pages 159-164

  Ducobu, J ^a  

^a Centre Hospitalier Universitaire de Tivoli   (Belgium)

Author keywords

Adiponectin; Appetite regulation; Endocannabinoids; Obesity; Rimonabant

Indexed keywords

ADIPONECTIN; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; ENDOCANNABINOID; NICOTINE; RIMONABANT;

APPETITE; ARTICLE; BODY FAT; FOOD INTAKE; HYPOTHALAMUS; INSULIN RESISTANCE; INSULIN SENSITIVITY; METABOLIC REGULATION; NONHUMAN; OBESITY; TOBACCO DEPENDENCE; WEIGHT REDUCTION;

ENDOCANNABINOIDS; HUMANS; METABOLISM;

EID: 21744458480     PISSN: 00353639     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Gaoni Y, Mechoulam R: Isolation, structure, and partial synthesis of an active constituent of hashish. J Am Chem Soc 1964; 86: 1646-7
2. Devane WA et al: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 1962; 258: 1946-9
3. Sugiura T et al: 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor. Science 1992; 258: 1950-3
4. Di Marzo V, Bifulco M, De Petrocellis L: The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 2004; 3: 771-84
5. Pertwee R: Pharmacology of cannabinoid CB and CB2 receptors. Pharmacol Ther 1997; 74: 129-80
6. Di Marzo V, Fontana A, Cadas H et al: Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 1994; 372: 686-91
7. Bisogno T, Howell F, Williams G et al: Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J Cell Biol 2003; 163: 463-8
8. Le Foll B, Goldberg SR: Cannabinoid CB1 receptor antagonists as promising new medications for drug dependence. J Pharmacol Exp Ther 2005; 312: 875-83
9. Marsicano G, Goodenough S, Monory K et al: CB, cannabinoid receptors and on-demand defense against excitotoxicity. Science 2003; 302: 84-8
10. Chevaleyre V, Castillo, PE: Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoïds in regulating excitability. Neuron 2003; 38: 461-72
11. Hajos N, Ledent C, Freund TF: Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus. Neuroscience 2001; 106: 1-4
12. Wagner JA, Varga K, Ellis EF et al: Activation of peripheral CB, cannabinoid receptors in haemorrhagic shock. Nature 1997; 390: 518-21
13. Baker D, Pryce G, Croxford JL et al: Endocannabinoïds control spasticity in a multiple sclerosis model. FASEB J 2001; 15: 300-2
14. Horvath TL: Endocannabinoïds and the regulation of body fat: the smoke is clearing. J Clin Invest 2003; 1129: 323-6
15. Rinaldi-Carmona M, Barth F, Heaulne M et al: SR141716A, a potent and selective antagonist of the brain cannabinoïd receptor. FEBS Lett 1994; 350: 240-4
16. Ravinet Trillou C, Amone M, Delgorge C et al: Anti-obesity effect of SR141716, a CB, receptor antagonist, in diet-induced obese mice. Am J Physiol Regul Integr Comp Physiol 2003; 284: R345-R53.
17. Di Marzo V, Goparaju SK, Wang L et al: Leptin-regulated endocannabinoïds are involved in maintaining food intake. Nature 2001; 410: 822-5
18. Cota D, Marsicano G, Tschop M et al: The endogenous cannabinoïd system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Inves 2003; 112: 423-31
19. Bensaid M, Gary-Bobo M, Esclangon A et al: The cannabinoïd CB, receptor antagonist SR141716 increases Acrp 30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells. Mol Pharmacol 2003; 63: 908-14
20. Van Gaal L, Rissanen AM, Scheen AJ, Ziegler O, Rössner S: Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe Study. Lancet 2005; 365: 1389-97