Use of conformationally restricted pyridinium α-D-N- acetylneuraminides to probe specificity in bacterial and viral sialidases

Biochemistry and Cell Biology

Volumn 83, Issue 2, 2005, Pages 115-122

  Watson, Jacqueline N ^a   Knoll, Tara L ^a   Chen, Johnny H ^a   Chou, Doug T H ^a   Borgford, Thor J ^a,c   Bennet, Andrew J ^a,b  

^a SIMON FRASER UNIVERSITY   (Canada)

^b Cardiome Pharma Corp   (Canada)

^c Twinstrand Therapeutics   (Canada)

Author keywords

Glycosidase; Mechanism; Neuraminidases; Sialic acids; Sialidases

Indexed keywords

BACTERIA; BIOCHEMISTRY; CATALYST ACTIVITY; CONFORMATIONS; VIRUSES;

BACTERIAL ENZYMES; CATALYTIC ACTIVITY; SIALIDASES; SIALYLATION;

ENZYMES;

3,4 DIHYDRO 2H PYRANO[3,2 C]PYRIDINIUM; 5 PYRIDINIUM N ACETYLNEURAMINIDE; BACTERIAL ENZYME; HN PROTEIN; PYRIDINIUM ALPHA DEXTRO N ACETYLNEURAMINIDE; PYRIDINIUM DERIVATIVE; SIALIDASE; UNCLASSIFIED DRUG; VIRUS SIALIDASE;

ARTICLE; CLOSTRIDIUM PERFRINGENS; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; NEWCASTLE DISEASE PARAMYXOVIRUS; SALMONELLA TYPHIMURIUM; SEQUENCE HOMOLOGY; SIALYLATION; VIBRIO CHOLERAE;

BINDING, COMPETITIVE; CLOSTRIDIUM PERFRINGENS; KINETICS; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; NEWCASTLE DISEASE VIRUS; PROTEIN CONFORMATION; PYRIDINIUM COMPOUNDS; RECEPTORS, VIRUS; SALMONELLA TYPHIMURIUM; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; VIBRIO CHOLERAE;

CLOSTRIDIUM PERFRINGENS; NEWCASTLE DISEASE VIRUS; SALMONELLA TYPHIMURIUM; VIBRIO CHOLERAE;

EID: 21744449386     PISSN: 08298211     EISSN: None     Source Type: Journal    
DOI: 10.1139/o04-126     Document Type: Article

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