Voluntary exercise training enhances glucose transport but not insulin signaling capacity in muscle of hypertensive TG(mREN2)27 rats

Journal of Applied Physiology

Volumn 99, Issue 1, 2005, Pages 357-362

  Lemieux, Andrew M ^a   Diehl, Cody J ^a   Sloniger, Julie A ^a   Henriksen, Erik J ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Akt; Glycogen synthase kinase 3; Insulin receptor substrate 1; Phosphatidylinositol 3 kinase; Soleus; Spontaneous running

Indexed keywords

GLUCOSE; GLYCOGEN SYNTHASE KINASE; GLYCOGEN SYNTHASE KINASE 3; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RENIN; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; EXERCISE; GLUCOSE TRANSPORT; HETEROZYGOSITY; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RAT STRAIN; RUNNING; SIGNAL TRANSDUCTION; SITTING; SKELETAL MUSCLE; SOLEUS MUSCLE; TRANSGENE;

ANIMALS; BIOLOGICAL TRANSPORT; EXERTION; GLUCOSE; HYPERTENSION; INSULIN; MALE; MULTIENZYME COMPLEXES; MUSCLE PROTEINS; MUSCLE, SKELETAL; PHYSICAL CONDITIONING, ANIMAL; RATS; RENIN; SIGNAL TRANSDUCTION;

EID: 21644451832     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00100.2005     Document Type: Article

References (36)

1. Boden G and Shulman GI. Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest 32, Suppl 3: 14-23, 2002.
2. Campbell DJ, Rong P, Kladis A, Rees B, and Skinner SL. Angiotensin and bradykinin peptides in the TGR(mREN2)27 rat. Hypertension 25: 1014-1020, 1995.
3. Chibalin AV, Yu M, Ryder JW, Song XM, Galuska D, Krook A, Wallberg-Henriksson H, and Zierath JR. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: differential effects on insulin receptor substrates 1 and 2. Proc Natl Acad Sci USA 97: 38-43, 2000.
4. Christ CY, Hunt D, Hancock J, Garcia-Macedo R, Mandarino LJ, and Ivy JL. Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats. J Appl Physiol 92: 736-744, 2002.
5. Christ-Roberts CY, Pratipanawatr T, Pratipanawatr W, Berria R, Belfort R, Kashyap S, and Mandarino LJ. Exercise training increases glycogen synthase activity and GLUT4 expression but not insulin signaling in overweight nondiabetic and type 2 diabetic subjects. Metabolism 53: 1233-1242, 2004.
6. Cross DA, Watt P, Shaw M, van der Kay J, Downes CP, Holder JC, and Cohen P. Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle and adipose tissue. FEBS Lett 406: 211-215, 1997.
7. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, Pedrinelli R, Brandi L, and Bevilacqua S. Insulin resistance in essential hypertension. N Engl J Med 317: 350-357, 1987.
8. Gulve EA, Henriksen EJ, Rodnick KJ, Youn JH, and Holloszy JO. Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol Endocrinol Metab 264: E319-E327, 1993.
9. Halbert JA, Silagy CA, Finucane P, Withers RT, Hamdorf PA, and Andrews GR. The effectiveness of exercise training in lowering blood pressure: a meta-analysis of randomised controlled trials of 4 weeks or longer. J Hum Hypertens 11: 641-649, 1997.
10. Hansen PA, Gulve EA, and Holloszy JO. Suitability of 2-deoxyglucose for in vitro measurement of glucose transport activity in skeletal muscle. J Appl Physiol 76: 979-985, 1994.
11. Henriksen EJ. Invited Review: Effects of acute exercise and exercise training on insulin resistance. J Appl Physiol 93: 788-796, 2002.
12. Henriksen EJ and Halseth AE. Early alterations in soleus GLUT-4, glucose transport, and glycogen in voluntary running rats. J Appl Physiol 76; 1862-1867, 1994.
13. Henriksen EJ and Jacob S. Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition. J Cell Physiol 196: 171-179, 2003.
14. Henriksen EJ, Jacob S, Kinnick TR, Teachey MK, and Krekler M. Selective angiotensin II receptor antagonism reduces insulin resistance in obese Zucker rats. Hypertension 38: 884-890, 2001.
15. Hevener AL, Reichart D, and Olefsky J. Exercise and thiazolidinedione therapy normalize insulin action in the obese Zucker fatty rat. Diabetes 49: 2154-2159, 2000.
16. Higashiura K, Ura N, Takada T, Li Y, Torii T, Togashi N, Takada M, Takizawa H, and Shimamoto K. The effects of an angiotenssin-converting enzyme inhibitor and an angiotensin II receptor antagonist on insulin resistance in fructose-fed rats. Am J Hypertens 13: 290-297, 2000.
17. Holness MJ and Sugden MC. The impact of genetic hypertension.on insulin secretion and glucoregulatory control in vivo: studies with the TGR(mREN2)27 transgenic rat. J Hypertens 16: 369-376, 1998.
18. Kim JY, Nolte LA, Hansen PA, Han DH, Ferguson K, Thompson PA, and Holloszy JO. High-fat diet-induced muscle insulin resistance: relationship to visceral fat mass. Am J Physiol Regul Integr Comp Physiol 279: R2057-R2065, 2000.
19. Kim Y, Inoue T, Nakajima R, Nakae K, Tamura T, Tokuyama K, and Suzuki M. Effects of endurance training on gene expression of insulin signal transduction pathway. Biochem Biophys Res Commun 210: 766-773, 1995.
20. Kim YB, Inoue T, Nakajima R, Shirai-Morishita Y, Tokuyama K, and Suzuki M. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Biochem Biophys Res Commun 254: 720-727, 1999.
21. Kinnick TR, Youngblood EB, O'Keefe MP, Saengsirisuwan V, Teachey MK, and Henriksen EJ. Modulation of insulin resistance and hypertension by voluntary exercise training in the TG(mREN2)27 rat. J Appl Physiol 93: 805-812, 2002.
22. Kokkinos PF and Papademetriou V. Exercise and hypertension. Coron Artery Dis 11: 99-102, 2000.
23. Langheinrich M, Lee MA, Bohm M, Pinto YM, Ganten D, and Paul M. The hypertensive Ren-2 transgenic rat TGR(mREN2)27 in hypertension research: characteristics and functional aspects. Am J Hypertens 9: 506-512, 1996.
24. Lee MA, Bohm M, Paul M, Bader M, Ganten U, and Ganten D. Physiological characterization of the hypertensive transgenic rat TGR (mREN2)27. Am J Physiol Endocrinol Metab 270: E919-E929, 1996.
25. Mullins JJ, Peters J, and Ganten D. Fulminant hypertension in transgenic rats harboring the Ren-2 gene. Nature 344: 541-544, 1990.
26. Ogihara T, Asano T, Katsuyuki A, Chiba Y, Sakoda H, Anai M, Shojima N, Ono J, Onishi Y, Fujishiro M, Katagiri H, Fukushima Y, Kikuchi M, Noguchi N, Aburatani H, Komuro I, and Fujita T. Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension 40: 872-879, 2002.
27. O'Keefe MP, Perez FR, Sloniger JA, Tischler ME, and Henriksen EJ. Enhanced insulin action on glucose transport and insulin signaling in 7-day unweighted rat soleus muscle. J Appl Physiol 97: 63-71, 2004.
28. Petrella RJ. How effective is exercise training for the treatment of hypertension? Clin J Sport Med 8: 224-231, 1998.
29. Reaven GM. Are insulin resistance and/or compensatory hyperinsulinemia involved in the etiology and clinical course of patients with hypertension? Int J Obes 19: S2-S5, 1995.
30. Richey JM, Ader M, Moore D, and Bergman RN. Angiotensin II induces insulin resistance independent of changes in interstitial insulin. Am J Physiol Endocrinol Metab 277: E920-E926, 1999.
31. Saengsirisuwan V, Perez FR, Sloniger JA, Maier T, and Henriksen EJ. Interactions of exercise training and α-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats. Am J Physiol Endocrinol Metab 287: E529-E536, 2004.
32. Sander M, Bader M, Djavidani B, Maser-Gluth C, Vecsei P, and Mullins J. The role of the adrenal gland in hypertensive transgenic rat TGR(mREN2)27. Endocrinology 131: 807-814, 1992.
33. Sasaki K, Kushiro T, Nakagawa S, and Kanmatsuse K. Effects of angiotensin II receptor antagonism on insulin sensitivity and sympathetic activity in spontaneously hypertensive rats. Nippon Jinzo Gakkai Shi 41: 692-696, 1999.
34. Sloniger JA, Kim JS, Saengsirisuwan V, Diehl CJ, Dokken BB, and Henriksen EJ. The angiotensin II receptor blocker irbesartan enhances whole-body insulin sensitivity and muscle glucose transport in the hypertensive TG(mREN2)27 rat (Abstract). FASEB J 19: A338, 2005.
35. Sloniger JA, Saengsirisuwan V, Diehl CJ, Dokken BB, Lailerd N, Lemieux AM, Kim JS, and Henriksen EJ. Defective insulin signaling in skeletal muscle of the hypertensive TG(mREN2)27 rat. Am J Physiol Endocrinol Metab 288: E1074-E1081, 2005.
36. Summers SA, Kao AW, Kohn AD, Backus GS, Roth RR, Pessin JE, and Birnbaum MJ. The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism. J Biol Chem 274: 17934-17940, 1999.