The impact of genetic hypertension on insulin secretion and glucoregulatory control in vivo: Studies with the TGR(mRen2)27 transgenic rat

Journal of Hypertension

Volumn 16, Issue 3, 1998, Pages 369-376

  Holness, Mark J ^a   Sugden, Mary C ^a,b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Euglycaemic hyperinsulinaemic clamp; Genetic hypertension; Glucose tolerance; Insulin; Transgenic rats

Indexed keywords

GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; HEREDITARY HYPERTENSION; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INTRAVENOUS GLUCOSE TOLERANCE TEST; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TRANSGENIC ANIMAL;

EID: 0031952398     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199816030-00014     Document Type: Article

References (33)

1. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, et al. Insulin resistance in essential hypertension. New Engl J Med 1987; 317:350-357.
2. Ferrari P, Weidman P. Insulin, insulin sensitivity and hypertension. J Hypertens 1990, 8:491-500.
3. Reaven GM. Are insulin resistance and/or compensatory hyperinsulinemia involved in the etiology and clinical course of patients with hypertension? Int J Obes 1995; 19:S2-S5.
4. Bonaro E, Zavaroni I, Pezzarossa A, Alpi O, Bruschi F, Dall'Aglio E, et al. Relationship between blood pressure and plasma insulin in non-obese and obese non-diabetic subjects. Diabetologia 1987; 30:719-723.
5. Mbanya J-CN, Thomas TH, Wilkinson R, Alberti KGMM, Taylor R. Hypertension and hyperinsulinemia: a relation in diabetes but not essential hypertension. Lancet 1988; i:733-734.
6. Mondon CE, Reaven GM. Evidence of abnormalities of insulin metabolism in rats with spontaneous hypertension. Metab Clin Exp 1988; 37:303-305.
7. Pollare T, Lithell H, Berne C. Insulin resistance is a characteristic feature of primary hypertension independent of obesity. Metab Clin Exp 1990; 39:167-174.
8. Shen D-C, Shieh S-M, Fuh MM-T, Wu D-A, Chen Y-D, Reaven GM. Resistance to insulin-stimulated glucose uptake in patients with hypertension. J Clin Endocrinol Metab 1988; 66:580-583.
9. Reaven GM. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993; 44:121-131.
10. Reaven GM. Syndrome X: 6 years later. J Intern Med Suppl 1994; 736:13-22.
11. Reaven GM. The fourth musketeer - from Alexandre Dumas to Claude Bernard. Diabetologia 1995; 38:3-13.
12. Horl WH, Schaefer RM, Heidland A. Abnormalities of carbohydrate metabolism in spontaneously hypertensive rats. Klin Wochenschr 1988; 66:924-927.
13. Yamori Y, Ohta K, Ohtaka M, Nara R, Horie R, Ooshima A. Glucose metabolism in spontaneously hypertensive rats. Jap Heart J 1978; 19:559-560.
14. Yamori Y, Ohtaka M, Ueshima H, Nara Y, Horie R, Shimamoto T, et al. Glucose tolerance in spontaneously hypertensive rats. Jap Heart J 1978; 42:841-847.
15. Tsutsu N, Takata Y, Nunoi K, Kikuchi M, Takishita S, Sadoshima S, et al. Glucose tolerance and insulin secretion in conscious and unrestrained normotensive and spontaneously hypertensive rats. Metab Clin Exp 1989; 38:63-66.
16. Buchanan TA, Sipos GF, Madrilejo N, Liu C, Campese VM. Hypertension without peripheral insulin resistance in spontaneously hypertensive rats. Am J Physiol 1992; 262:E14-E19.
17. Hulman S, Falkner B, Freyvogel N. Insulin resistance in the conscious spontaneously hypertensive rat: euglycaemic hyperinsulinaemic clamp study. Metabolism 1993; 42:14-18.
18. Rao RH. Insulin resistance in spontaneously hypertensive rats. Difference in interpretation based on insulin infusion rate or on plasma insulin in glucose clamp studies. Diabetes 1993; 42:1364-1371.
19. Frontoni S, Ohman L, Haywood JR, DeFronzo RA, Rossetti L. In vivo insulin action in genetic models of hypertension. Am J Physiol 1992; 262:E191-E196.
20. Mullins JJ, Peters J, Ganten D. Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature 1990; 344:541-544.
21. Veniant M, Whitworth CE, Menard J, Sharp MG, Gonzales MF, Bruneval P, et al. Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats. Am J Hypertens 1995; 8:1167-1176.
22. Lee MA, Bohm M, Kim S, Bachmann S, Bachmann J, Bader M, et al. Differential gene expression of renin and angiotensinogen in the TGR(mRen-2)27 transgenic rat. Hypertension 1995; 25:570-580.
23. Bohm M, Lee M, Kreutz R, Kim S, Schinke M, Djavidani B, et al. Angiotensin II receptor blockade in TGR(mRen2)27: effects of renin-angiotensin-system gene expression and cardiovascular functions. J Hypertens 1995; 13:891-899.
24. Mitchell KD, Jacinto SM, Mullins JJ. Proximal tubular fluid, kidney, and plasma levels of angiotensin II in hypertensive ren-2 transgenic rats. Am J Physiol 1997; 273:F246-F253.
25. Sander M, Bader M, Djavidani B, Maser-Gluth C, Vecsei P, Mullins J, et al. The role of the adrenal gland in hypertensive transgenic rat TGR(mRen2)27. Endocrinology 1992; 131:807-814.
26. Holness MJ, Sugden MC. Suboptimal protein nutrition in early life later influences insulin action in pregnant rats. Diabetologia 1996; 39:12-21.
27. Holness MJ. Impact of early growth retardation on glucoregulatory control and insulin action in mature rats. Am J Physiol 1996; 270:E946-E954.
28. Postnov YV, Gorkova SI, Solovyova LP. Reduction of the β-cell component of pancreatic islets in spontaneously hypertensive rats. Virchows Arch 1976; 371:79-87.
29. Mondon CE, Reaven GM, Azhar S, Lee CM, Rabkin R. Abnormal insulin metabolism by specific organs from rats with spontaneous hypertension. Am J Physiol 1989; 257:E491-E498.
30. Finch D, Davis G, Bower J, Kirchner K. Effect of insulin in renal sodium handling in hypertensive rats. Hypertension 1990; 15:514-518.
31. Leighton B, Sanderson AL, Young ME, Radda GK, Boehm EA, Clark JF. Effects of treatment of spontaneously hypertensive rats with the angiotensin-converting enzyme inhibitor trandolapril and the calcium antagonist verapamil on the sensitivity of glucose metabolism to insulin in rat soleus muscle in vitro. Diabetes 1996; 45 (suppl 1):S120-S124.
32. Katayama S, Abe M, Kashiwabara H, Kosegawa I, Ishii J. Evidence against a role of insulin in hypertension in spontaneously hypertensive rats. Hypertension 1994; 23:1071-1074.
33. Modan M, Halkin H, Almog S, Lusky A, Eshkoi A, Shefi M, et al. Hyperinsulinemia. A link between hypertension obesity and glucose intolerance. J Clin Invest 1985; 75:809-817.