High frequency methylation of p16INK4A gene during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis

Oncology Reports

Volumn 12, Issue 1, 2004, Pages 101-106

  Nakahara, Yuuji ^a   Shintani, Satoru ^a   Mihara, Mariko ^a   Matsumura, Tomohiro ^b   Hamakawa, Hiroyuki ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

4 nitroquinoline 1 oxide (4NQO); Hypermethylation; Oral cancer; Rat carcinogenesis

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; CARCINOGEN; DNA; PRIMER DNA; PROTEIN P16INK4A;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DNA METHYLATION; DRUG EFFECT; EXON; GENETICS; HETEROZYGOSITY LOSS; MOUTH MUCOSA; NUCLEOTIDE SEQUENCE; PATHOLOGY; RAT; SQUAMOUS CELL CARCINOMA; TONGUE TUMOR;

4-NITROQUINOLINE-1-OXIDE; ANIMALS; BASE SEQUENCE; CARCINOGENS; CARCINOMA, SQUAMOUS CELL; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA METHYLATION; DNA PRIMERS; DNA, NEOPLASM; EXONS; LOSS OF HETEROZYGOSITY; MOUTH MUCOSA; RATS; TONGUE NEOPLASMS;

EID: 21644437785     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.12.1.101     Document Type: Article

References (33)

1. Parkin D, Laara E and Muir C: Estimates of the worldwide frequency of sixteen major cancers in 1980. Int J Cancer 41: 184-197, 1998.
2. Boyle JO, Hakim J, Koch W, van der Riet P, Hruban RH, Roa RA, Correo R, Eby YJ, Ruppert JM and Sidransky D: The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53: 4477-4480, 1993. (Pubitemid 23304366)
3. Van der Riet P, Nawroz H, Hruban RH, Corio R, Tokino K, Koch W and Sidransky D: Frequent loss of chromosome 9p21-22 early in head and neck cancer progression. Cancer Res 54: 1156-1158, 1994. (Pubitemid 24108049)
4. Gonzalez MV, Pello MF, Lopez-Larrea C, Suarez C, Menendez MJ and Coto E: Loss of heterozygosity and mutation analysis of the p16 (9p21) and p53 (17pl3) genes in squamous cell carcinoma of the head and neck. Clin Cancer Res 1: 1043-1049, 1995.
5. Serrano M, Hannon GJ and Beach DA: New regulatory motif in cell-cycle control causing specific inhibition of cyclin D/cdk4. Nature 16: 704-707, 1993. (Pubitemid 24036021)
6. Kamb A, Gnus NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS III, Johnson BE and Skolnick MH: A cell cycle regulator potentially involved in genesis of many tumor types. Science 15: 436-439, 1994.
7. Nobori T, Miura K, Wu D, Lois A, Takabayashi K and Carson D: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 21: 753-756, 1994. (Pubitemid 24153417)
8. INK4A. Science 13: 249-252, 1995.
9. Herman JB, Merlo A and Mao L: Inactivation of CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 15: 4525-453, 1995.
10. Gonzalez-Zulueta M, Bender CM, Yang AS, Nguyen TD, Beart RW and van Torout JM: Methylation of 5′CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 15: 4531-4535, 1995.
11. Nakahara Y, Shintani S, Mihara M, Kiyota A, Ueyama Y and Matsumura T: Alteration of Rb, p16 and cyclin D1 in the tumorigenesis of squamous cell carcinoma. Cancer Lett 160: 3-8, 2000.
12. INK4A gene in oral squamous cell carcinomas. Cancer Lett 163: 221-228, 2001.
13. Navarro CM, Paes de Almeida O and Scully C: Oral focal acantholytic dyskeratosis induced in sialoadenectomized rats painted orally with the carcinogen 4-nitroquinoline N-oxide. Bull Tokyo Dent Coil 34: 191-194, 1993.
14. Kitano M, Hirayama Y, Tanuma J, Matsuuchi H, Miura Y, Li TJ, Semba I, Ozaki HS, Kokubu T, Hatano H, Tada M, Kobayashi Y and Shisa H: Genetic controls of susceptibility and resistance to 4-nitroquinoline 1-oxide-induced tongue carcinomas in rats. Jpn J Cancer Res 87: 1097-1101, 1996. (Pubitemid 26420014)
15. Funato T, Hoshino A and Kawamura T: Evaluation od a commercial extraction kit (Sepa Gene) for DNA diagnosis. Jpn J Med Pharm 29: 1401-1404, 1993.
16. Kuwano K and Arai S: The inhibitory effect of FK506 on cytotoxic T-lymphocyte killing. Immunol Lett 43: 153-157, 1994.
17. Swafford DS, Middleton SK, Palmisano WA, Nikula KJ, Tesfaigzi J, Baylin SB, Herman JG and Belinsky SA: Frequent aberrant methylation of p16INK4a in primary rat lung tumors. Mol Cell Biol 17: 1366-1374, 1997. (Pubitemid 27097365)
18. Ikeda K, Monden T, Tsujie M, Izawa H, Yamamoto H, Ohnishi T, Ohue M, Sekimoto M, Tomita N and Monden M: Cyclin D, CDK4 and p16 expression in colorectal cancer. Nippon Rinsho 54: 1054-1059, 1996.
19. Chi S, De Vere White RW, Muenzer JT and Gumerlock PH: Frequent alteration of CDKN2 (p16ink4A/MTS1) expression in human primary prostate carcinoma. Clin Cancer Res 3: 1889-1897, 1997. (Pubitemid 27444732)
20. Ichikawa Y, Yoshida S, Koyama Y, Hirai M, Ishikawa T, Nishida M, Tsunoda H, Kubo T, Miwa M and Uchida K: Inactivation of p16/CDKN2 and p15/MTS2 genes in different histological type and clinical stage of primary ovarian tumors. Int J Cancer 20: 466-470, 1996. (Pubitemid 27050523)
21. Maelandsmo GM, Florenes VA, Hovig E, Oyjord T, Engebraaten O, Holm R, Borresen AL and Fodstad O: Involvement of the pRb/p16/cdk4/cyclin D1 pathway in the tumorigenesis of sporadic malignant melanoma. Br J Cancer 73: 909-916, 1996. (Pubitemid 26116742)
22. Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ and Rollins BJ: Reciprocal Rb inactivation and p16ink4A expression in primary lung carcinoma. Cancer Res 55: 505-509, 1995.
23. Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A and Louis DN: CDKN2/p16 or Rb alterations occur in majority of glioblastomas and are inversely correlated. Cancer Res 56: 150-153, 1996. (Pubitemid 26010393)
24. Timmermann S, Hinds PW and Munger K: Re-expression of endogenous p16 in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state. Oncogene 17: 3445-3453, 1998. (Pubitemid 29050679)
25. Xing EP, Nie Y, Song Y, Yang GY, Cai YC, Wang LD and Yang CS: Mechanism of inactivation of p14, p15 and p16 genes in human esophageal squamous cell carcinoma. Clin Cancer Res 5: 2704-2713, 1999. (Pubitemid 29493943)
26. Steidler NE and Reade PC: Initiation and promotion of experimental oral mucosal carcinogenesis in mice. J Oral Pathol 15: 43-47, 1986.
27. Ohne M, Satoh T, Yamada S and Takai H: Experimental tongue carcinoma of rats induced by oral administration of 4-nitroquinoline 1-oxide (4NQO) in drinking water. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 59: 600-607, 1985. (Pubitemid 15045687)
28. Enterline H and Thompson J: Pathology of the Esophagus. Springer-Verlag, New York, pp145-163, 1984.
29. Silverman S Jr, Gorsky M and Lozada F: Oral leukoplakia and malignant transformation. A follow-up study of 257 patients. Cancer 53: 563-568, 1984. (Pubitemid 14182737)
30. Lumerman H, Freedman P and Kerpel S: Oral epithelial dysplasia and the development of invasive squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 79: 321-329, 1995.
31. Slaughter DP, Southwick HW and Smejkal W: 'Field cancerization' in oral stratified squamous epithelium: clinical implication of multicentric origin. Cancer 6: 963-968, 1953.
32. Takagi M, Sakota Y and Ishikawa G: Histopathologic study of the squamous cell carcinoma of the oral mucosa. 1. Relationship between leukoplakia and invasive carcinoma. Kokubyo Gakkai Zasshi 42: 364-372, 1975.
33. Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB and Herman JG: Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA 95: 11891-11896, 1998.