Thiolysable prodrugs of 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine with antineoplastic activity

European Journal of Medicinal Chemistry

Volumn 33, Issue 7-8, 1998, Pages 609-615

  Shyam, Krishnamurthy ^a   Penketh, Philip G ^a   Loomis, Regina H ^a   Sartorelli, Alan C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alkylating agents; Bis(sulfonyl)hydrazines; Drug resistance; Glutathione; Glutathione S transferase

Indexed keywords

1 (2 CHLOROETHYL) 1,2 BIS(METHYLSULFONYL)HYDRAZINE; 1 (2 CHLOROETHYL) 1,2 BIS(METHYLSULFONYL)HYDRAZINE DERIVATIVE; ANTINEOPLASTIC AGENT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDRAZINE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKEMIA L 1210; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL;

EID: 0032124514     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(98)80019-6     Document Type: Article

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