The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase

Cancer Chemotherapy and Pharmacology

Volumn 49, Issue 2, 2002, Pages 101-110

  Fourie, Jeanne ^a   Oleschuk, Curtis J ^a   Guziec, Frank ^b   Guziec, Lynn ^b   Fiterman, Derek J ^b   Monterrosa, Cielo ^a   Begleiter, Asher ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b SOUTHWESTERN UNIVERSITY   (United States)

Author keywords

Bioreductive agents; DT diaphorase; Structure activity studies

Indexed keywords

2 [DI(CHLOROETHYL)AMINO] 1,4 BENZOQUINONE; 5 CHLORO 2 [DI(CHLOROETHYL)AMINO] 1,4 BENZOQUINONE; 5 METHOXY 2 [DI(CHLOROETHYL)AMINO] 1,4 BENZOQUINONE; 5 METHYL 2 [DI(CHLOROETHYL)AMINO] 1,4 BENZOQUINONE; 5 PHENYL 2 [DI(CHLOROETHYL)AMINO] 1,4 BENZOQUINONE; 6 PHENYL 2 [DI(CHLOROETHYL)AMINO] 1,4 BENZOQUINONE; BENZOQUINONE DERIVATIVE; CYTOCHROME P450; DICOUMAROL; FUNCTIONAL GROUP; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOMER; LUNG NON SMALL CELL CANCER; MELANOMA; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; BENZOQUINONES; BIOTRANSFORMATION; CARCINOMA, NON-SMALL-CELL LUNG; HUMANS; LUNG NEOPLASMS; NAD; NAD(P)H DEHYDROGENASE (QUINONE); OXIDATION-REDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036161108     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-001-0395-1     Document Type: Article

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