Radiobiological rationale and patient selection for high-LET radiation in cancer therapy

Radiotherapy and Oncology

Volumn 73, Issue SUPPL. 2, 2004, Pages

  Wambersie, André ^a,e   Hendry, Jolyon ^b   Gueulette, John ^a   Gahbauer, Reinhard ^c   Pötter, Richard ^d   Grégoire, Vincent ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b INTERNATIONAL ATOMIC ENERGY AGENCY   (Austria)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF VIENNA   (Austria)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Cancer therapy; Clinical indications; Fast neutrons; High LET radiation; Ions; Protons; Radiobiology

Indexed keywords

ION;

CANCER CLASSIFICATION; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CONFERENCE PAPER; NEUTRON; PRIORITY JOURNAL; PROTON RADIATION; RADIATION BEAM; RADIATION PHYSICS; RADIOBIOLOGY; RADIOSENSITIVITY; TREATMENT INDICATION; ARTICLE; FAST NEUTRON RADIATION; HUMAN; LINEAR ENERGY TRANSFER; MALE; NEOPLASM; PATIENT SELECTION; PROSTATE TUMOR; RADIATION DOSE FRACTIONATION; SALIVARY GLAND TUMOR;

DOSE FRACTIONATION; FAST NEUTRONS; HUMANS; LINEAR ENERGY TRANSFER; MALE; NEOPLASMS; PATIENT SELECTION; PROSTATIC NEOPLASMS; SALIVARY GLAND NEOPLASMS;

EID: 21444453653     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(04)80004-5     Document Type: Conference Paper

References (65)

1. Barendsen G.W. Responses of cultured cells, tumours and normal tissues to radiations of different linear energy transfer Curr. Top. Radiat. Res. Quarterly, North Holland, Amsterdam 4 1968 293
2. Barendsen G.W. The relationship between RBE and LET for different types of lethal damage in mammalian cells: biophysical and molecular mechanisms Radiation Research 139 1994 257 270
3. Jun 1 Barthel H, Wilson H, Collingridge DR, Brown G, Osman S, Luthra SK, Brady F, Workman P, Price PM, and Aboagye EO In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography Br J Cancer 90 11 2004 2232 2242
4. Battermann J.J., Breur K., Hart G.A.M., and van Peperzeel H.A. Observations on pulmonary metastases in patients after single doses and multiple fractions of neutrons and cobalt-60 gamma rays Eur.J.Cancer 17 1981 539
5. Jan 1 Brenner DJ, Martinez AA, Edmundson GK, Mitchell C, Thames HD, and Armour EP Direct evidence that prostate tumors show high sensitivity to fractionation (low alpha/beta ratio), similar to late-responding normal tissue Int J Radiat Oncol Biol Phys 52 1 2002 6 13
6. Breteau N. Le Bourgeois J.-P. Barendsen G.W. Stannard C.E. Rosenwald J.-C. Wambersie A. Hadrons in radiation therapy Bulletin du Cancer/ Radiothérapie Vol 83 1996
7. Brizel D, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, and Dewirst MW Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma Cancer Res 56 1996 941 943
8. Jun Brock WA, Baker FL, Wike JL, Sivon SL, and Peters LJ Cellular radiosensitivity of primary head and neck squamous cell carcinomas and local tumor control Int J Radiat Oncol Biol Phys 18 6 1990 1283 1286
9. J.R. Castro, G.T.Y. Chen, and E.A. Blakeley Current considerations in heavy charged particle radiotherapy Rad. Research 104 Suppl.8 1985 S263 S271
10. 394 pages M. Catteral, and D. Bewley Fast neutrons in the treatment of cancer 1979 Academic Press Weinheim, Germany
11. Chapman J.D. Biophysical models of mammalian cell inactivation by radiation R.E. Meyn H.R. Withers Radiation biology in cancer research 1968 Raven Press London 21
12. Aug 1 Cooper RA, West CM, Logue JP, Davidson SE, Miller A, Roberts S, Statford IJ, Honess DJ, and Hunter RD Changes in oxygenation during radiotherapy in carcinoma of the cervix Int J Radiat Oncol Biol Phys 45 1 1999 119 126
13. Oct Cooper RA, Carrington BM, Loncaster JA, Todd SM, Davidson SE, Logue JP, Luthra AD, Jones AP, Stratford I, Hunter RD, and West CM Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix Radiother Oncol 57 1 2000 53 59
14. R. Engenhart-Cabillic A. Wambersie Fast neutrons and high-LET particles in cancer therapy, Recent results in cancer research 1998 Springer New York
15. Evans SM, Kachur AV, and Shiue CA Noninvasive detection of tumor hypoxia using the 2-nitroimidazole [18F]EF1 J. Nucl. Med. 41 2000 327 336
16. Fertil B., Deschavanne P.J., Gueulette J., Possoz A., Wambersie A., and Malaise E.P. In vitro radiosensitivity of six human cell lines. II. Relation to RBE of 50 MeV neutrons radiation Research 90 1982 526 537
17. Aug Field SB, and Hornsey S Slow repair after x-rays and fast neutrons Br J Radiol 50 596 1977 600 601
18. Gahbauer R A challenge for high-precision radiation therapy: the case for photons Strahlentherapie und Onkologie 175 1999 121 122
19. Gatenby RA, Kessler HB, and Rosenblaum JS Oxygen distribution in squamous cell carcinoma mestastases and its relationship to outcome of radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 14 1988 831 838
20. Gueulette J., Menzel H.G., Pihet P., and Wambersie A. Specification of radiation quality in fast neutron therapy: microdosimetric and radiobiological approach R. Engenhart-Cabillic A. Wambersie Fast neutrons and high-LET particles in cancer therapy, Recent Results in Cancer Research Vol. 150 1998 Springer-Verlag Heidelberg 31 53
21. Jul Hendry JH Quantitation of the radiotherapeutic importance of naturally-hypoxic normal tissues from collated experiments with rodents using single doses Int J Radiat Oncol Biol Phys 5 7 1979 971 976
22. Jul 16 Henk JM, Kunkler PB, and Smith CW Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial Lancet 2 8029 1977 101 103
23. Hockel M., Schlenger K., Aral B., Mitze M., Schaffer U., and Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix Cancer Res. 56 1996 4509 4515
24. Dec Horiot JC, Le Fur R, N'Guyen T, Chenal C, Schraub S, Alfonsi S, Gardani G, Van Den Bogaert W, Danczak S, and Bolla M Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy Radiother Oncol 25 4 1992 231 241
25. Horsman MR and Overgaard J. Overcoming tumour radioresistance resulting from hypoxia. In: Basic clinical radiobiology, pages 169-181. Editor GG Steel. Arnold.
26. ICRP, International Commission on Radiological Protection Report of the RBE Subcommittee to the International Commission on Radiological Protection and the International Commission on Radiation Units and Measurements Health Physics 9 1963 357 386
27. Bethesda, Maryland 20914-3095, USA ICRU, International Commission on Radiation Units and Measurements Quantitative concepts and dosimetry in radiobiology ICRU Report 30 1979
28. Bethesda, Maryland 20914-3095, USA ICRU, International Commission on Radiation Units and Measurements Microdosimetry ICRU Report 36 1993
29. 7910 Woodmont Avenue, Bethesda, Maryland, 20814-3095 ICRU, International Commission on Radiation Units and Measurements Prescribing, recording and reporting photon beam therapy ICRU Report 50 1993
30. Bethesda, Maryland 20914-3095, USA ICRU, International Commission on Radiation Units and Measurements Quantities and units in radiation protection dosimetry ICRU Report 51 1993
31. Bethesda, Maryland 20914-3095, USA ICRU, International Commission on Radiation Units and Measurements Fundamental quantities and units for ionizing radiation ICRU Report 60 1998
32. 7910 Woodmont Avenue, Bethesda, Maryland, 20814-3095 ICRU, International Commission on Radiation Units and Measurements Prescribing, recording and reporting photon beam therapy (Supplement to ICRU Report 50) ICRU Report 62 1999
33. Kaanders J.H.A.M., Wijffels K.I.E.M., Marres H.A.M., Pop L.A.M., Marres H.A.M., Ljungkvist A.S.E., Pop L.A.M., van den Hoogen F.J.A., de Wilde P.C.M., Bussink J., Raleigh J.A., and van der Kogel A.J. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer Cancer Res 62 2002 7066 7074
34. Review Koch CJ, and Evans SM Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles Adv Exp Med Biol 510 2003 285 292
35. Koh WJ, Rasey JS, Evans ML, Grierson JR, Lewellen TK, Graham MM, Krohn KA, and Griffin TW Imaging of hypoxia in human tumors with [F18] fluoromisonidazole Int J Radiat Oncol Biol Phys 22 1 1992 199 212
36. Krüll A., Schwarz R., Brackrock S., Engenhart-Cabillic R., Huber P., Prott F.J., Breteau N., Favre A., Lessel A., Koppe H., and Auberger T. Neutron therapy in malignant salivary gland tumors: Results at European centres Rita Engenhart-Cabillic André Wambersie Fast neutrons and high-LET particles in cancer therapy 1998 Springer Heidelberg 88
37. Laramore G.E., Krall J.M., and Thomas F.J. Fast neutron radiotherapy for locally advanced prostate cancer: final report of a radiation therapy oncology group randomized clinical trial Am.J.Clin.Oncol. 16 1993 164 167
38. Lindsley K.L., Cho P., Stelzer K.J., Koh W.J., Austin-Seymour M., Russel K.J., Laramore G.E., and Griffin T.W. Clinical trials of neutron radiotherapy in the United States Bulletin du Cancer/Radiothérapie Vol.83 Suppl. 1 1996 78s
39. Nov 1 Loncaster JA, Carrington BM, Sykes JR, Jones AP, Todd SM, Cooper R, Buckley DL, Davidson SE, Logue JP, Hunter RD, and West CM Prediction of radiotherapy outcome using dynamic contrast enhanced MRI of carcinoma of the cervix Int J Radiat Oncol Biol Phys 54 3 2002 759 767
40. Jan Mackay RI, and Hendry JH The modelled benefits of individualizing radiotherapy patients' dose using cellular radiosensitivity assays with inherent variability Radiother Oncol 50 1 1999 67 75
41. (in press) P. Mahy, Ph. Leveque, M. De Bast, D. Labar, J. Gillart, J. Marchand, and V. Grégoire Pharmacokinetics and biodistribution of the hypoxic tracer [18F]-[2-(2-Nitroimidazol-1 [H]-yl)-N-(3,3,3-trifluoroprophyl)- acetamide], [18F]-EF3 European J. Nucl. Medicine 2004
42. Menzel H.G., Pihet P., and Wambersie A. Microdosimetric specification of radiation quality in neutron radiation therapy Int.J.Radiat.Biol. 57 1990 865 883
43. Miyamoto T., Yamamoto N., Nishimura H., Koto M., Tsujii H., Mizoe J., Kamada T., Kato H., Yamada S., Morita S., Yoshikawa K., Kandatsu S., and Fujisawa T. Carbon ion radiotherapy for stahe I non-samll cell lung cancer Radiotherapy and Oncology 66 2003 127 140
44. Munzenrider J.E., Liebsch N.J., Proton therapy for tumors of the skull base, Strahlentherapie und Onkologie, 175, Suppl II, 57-63.
45. Feb Overgaard J, Hansen HS, Overgaard M, Bastholt L, Berthelsen A, Specht L, Lindelov B, and Jorgensen K A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85 Radiother Oncol. 46 2 1998 135 146
46. Pihet P. Etude microdosimétrique de faisceaux de neutrons de haute énergie. Applications dosimétriques et radiobiologiques Thesis 1989 Université Catholique de Louvain Heidelberg
47. Pötter R. Auberger T. Wambersie A. Hadrons-A challenge for high-precision radiotherapy Strahlenther. Onkol. 175 1999
48. Raleigh JA, Dewhirst MW, and Thrall DE Measuring tumor hypoxia Sem. Radiat. Oncol. 6 1996 37 40
49. Rasey JS, Koh WJ, and Evans ML Quantifying regional hypoxia in human tumors with positron emission tomography of [18F] Fluoromisonidazole: a pretherapy study of 37 patients Int. J. Radiat. Oncol. Biol. Phys. 36 1996 417 428
50. Russell K.J., Caplan R.J., and Laramore G.E. Photon versus fast neutron external beam radiotherapy in the treatment of locally advanced prostate cancer: results of a randomized prospective trial Int. J. Radiat. Oncol. Biol. Phys. 28 1993 47 54
51. Jun Stewart FA, Denekamp J, and Randhawa VS Skin sensitization by misonidazole: a demonstration of uniform mild hypoxia Br J Cancer 45 6 1982 869 877
52. Stone R.S. Neutron therapy and specific ionization Am. J. Roentgenol. 59 1948 771
53. Stone HB, Brown JM, Phillips TL, and Sutherland RM Oxygen in human tumors: correlations between methods of measurements and response to therapy Radiat. Res. 136 1993 422 434
54. Dec. Tsujii H., Mizoe J., Kamada T., Baba M., Kato S., Kato H., Tsuji H., Yamada S., Yasuda S., Ohno T., Yanagi T., Hasegawa A., Sugarawa T., Ezawa H., Kandatsu S., Yoshikawa K., Kishimoto R., and Miyamoto T. Overview of clinical experience on carbon ion radiotherapy at NIRS, Radiation Oncology Radiother Oncol. Vol 73 2004
55. 371 pages M. Tubiana, J. Dutreix, and A. Wambersie Introduction to Radiobiology 1990 Taylor & Francis Louvain-la-Neuve, Belgium
56. van der Kogel A.J. Late effects of radiation on the spinal cord: dose effect relationships and pathogenesis Thesis 1979 University of Amsterdam, Publication of the Radiobiological Institute TNO London
57. Wambersie A. Neutron therapy: from radiobiological expectation to clinical reality H.D. Kogelnik Progess in Radio-Oncology V 1995 Monduzzi Publ. Rijswijk, The Netherlands 685 690
58. Wambersie A., Barendsen G.W., and Breteau N. Overview and prospects of the application of fast neutrons in cancer therapy J. Eur. Radiothér. 5 1984 248
59. Wambersie A., Chauvel P., Gademann G., Gérard J.-P., and Sealy R. Commission of the European Communities, Concerted action: Cancer treatment with light ions in Europe-EULIMA, Final Report-Part 1: General feasibility study, Socio-economic study 1992 EC Bologna, Italy 2 39
60. Wambersie A., Gueulette J., Jones D.T.L., and Gahbauer R. Ion-Beam Therapy: Rationale, Achievements and Expectations, Chap.25 Hatano Mozumder Particle and photon interactions with matter 2003 Marcel Dekker Brussels 743 784
61. A. Wambersie, and R. Gahbauer Hadrons (protons, neutrons, heavy ions) in radiation therapy: rationale, achievements and expectations Radiochemical Acta 89 2001 245 253
62. A. Wambersie, H.G. Menzel, R.A. Gahbauer, P. DeLuca, and G. Whitmore RBE and harmonisation in prescribing, recording and reporting hadron therapy H.D. Kogelnik P. Lucas F. Seldmayer Progress in Radio-Oncology VII 2002 Monduzzi Editore New York 361 371
63. A. Wambersie, H.G. Menzel, R.A. Gahbauer, D.T.L. Jones, B.D. Michael, and H. Paretzke Biological weighting of absorbed dose in radiation therapy Radiation Protection Dosimetry 99 2002 445 452
64. A. Wambersie, R. Gahbauer, and G. Menzel RBE and weighting of absorbed dose in ion-beam therapy Radiotherapy and Oncology Vol 73 Suppl. 2 2004
65. Dec Withers HR, Thames HD Jr, and Peters LJ Biological bases for high RBE values for late effects of neutron irradiation Int J Radiat Oncol Biol Phys. 8 12 1982 2071 2076