Medication-induced oesophageal disorders

Expert Opinion on Drug Safety

Volumn 2, Issue 5, 2003, Pages 495-507

  Petersen, Karl Uwe ^a   Jaspersen, Daniel ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Department of Gastroenterology   (Germany)

Author keywords

alendronate; antimuscarinic drugs; aspirin; clindamycin; cyclooxygenase 2 (COX 2) inhibitors; drug formulation; ferrous sulfate; gastro oesophageal reflux disease (GORD); lower oesophageal sphincter pressure; nicotine; nifedipine; nitrates; NSAIDs; oesophageal toxicity; potassium chloride; quinidine; sildenafil; tetracyclines; theophylline

Indexed keywords

DRUG;

CHEMICALLY INDUCED DISORDER; ESOPHAGUS DISEASE; HUMAN; MICROCAPSULE; ORAL DRUG ADMINISTRATION; PHARMACOLOGY; REVIEW; TABLET;

ADMINISTRATION, ORAL; CAPSULES; ESOPHAGEAL DISEASES; HUMANS; PHARMACEUTICAL PREPARATIONS; PHARMACOLOGY; TABLETS;

EID: 2142790500     PISSN: 14740338     EISSN: 1744764X     Source Type: Journal    
DOI: 10.1517/14740338.2.5.495     Document Type: Review

References (137)

1. KIKENDALL JW: Pill esophagitis. J. Clin. Gastroenterol. (1999) 28(4):298-305. (Pubitemid 29246403)
2. BOYCE HW Jr: Drug-induced esophageal damage: diseases of medical progress. Gastrointest. Endosc. (1998) 47(6):547-550.
3. JASPERSEN D: Drug-induced oesophageal disorders: pathogenesis, incidence, prevention and management. Drug Saf. (2000) 22(3):237-249. (Pubitemid 30157584)
4. OTTERVANGER JP, WILSON JH, STRICKER BH: Drug-induced chest pain and myocardial infarction. Reports to a national centre and review of the literature. Eur. J. Clin. Pharmacol. (1997) 53(2):105-110. (Pubitemid 27491661)
5. BENNETT J: ABC of the upper gastrointestinal tract. Oesophagus: atypical chest pain and motility disorders. Br. Med. J. (2001) 323(7316):791-794. (Pubitemid 32946770)
6. STORR M, ALLESCHER HD: Esophageal pharmacology and treatment of primary motility disorders. Dis. Esophagus (1999) 12(4):241-257. (Pubitemid 30195422)
7. VAEZI MF, RICHTER JE: Diagnosis and management of achalasia. American College of Gastroenterology Practice Parameter Committee. Am. J. Gastroenterol. (1999) 94(12):3406-3412.
8. HONGO M, TRAUBE M, MCCALLUM RW: Comparison of effects of nifedipine, propantheline bromide, and the combination on esophageal motor function in normal volunteers. Dig. Dis. Sci. (1984) 29(4):300-304. (Pubitemid 14131550)
9. AGGESTRUP S, JENSEN SL: Effects of pirenzepine and atropine on basal lower esophageal pressure and gastric acid secretion in man: a placebo-controlled randomized study. Dig. Dis. (1991) 9(6):360-364.
10. MITTAL RK, HOLLOWAY R, DENT J: Effect of atropine on the frequency of reflux and transient lower esophageal sphincter relaxation in normal subjects. Gastroenterology (1995) 109(5):1547-1554.
11. LIDUMS I, CHECKLIN H, MITTAL RK, HOLLOWAY RH: Effect of atropine on gastro-oesophageal reflux and transient lower oesophageal sphincter relaxations in patients with gastro-oesophageal reflux disease. Gut (1998) 43(1):12-16. (Pubitemid 28335483)
12. CICCAGLIONE AF, GROSSI L, CAPPELLO G et al.: Effect of hyoscine N-butylbromide on gastroesophageal reflux in normal subjects and patients with gastroesophageal reflux disease. Am. J. Gastroenterol. (2001) 96(8):2306-2311. (Pubitemid 32776241)
13. BROCK-UTNE JG, RUBIN J, WELMAN S, DIMOPOULOS GE, MOSHAL MG, DOWNING JW: The action of commonly used antiemetics on the lower oesophageal sphincter. Br. J. Anaesth. (1978) 50(3):295-298. (Pubitemid 9058526)
14. BLACKWELL JN, DALTON CB, CASTELL DO: Oral pirenzepine does not affect esophageal pressures in man. Dig. Dis. Sci. (1986) 31(3):230-235. (Pubitemid 16123966)
15. PEHL C, WENDL B, KAESS H, PFEIFFER A: Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment. Pharmacol. Ther. (1998) 12(10):979-984. (Pubitemid 28454380)
16. OLANOW CW, WATTS RL, KOLLERWC: An algorithm (decision tree) for the management of Parkinson's disease (2001): treatment guidelines. Neurology (2001) 56(11 Suppl. 5):S1-S88; (Pubitemid 32532291)
17. Aliment. Pharmacol. Ther. (1998) 12(10):979-984.
18. HARMAN JL, LIMBIRD LE: Goodman-Gilman's The pharmacological basis of therapeutics (9th edn), McGraw-Hill, New York (1996):433.
19. TYBER MA: The relationship between hiatus hernia and tricyclic antidepressants: a report of five cases. Am. J. Psychiatry (1975) 132(6):652-653.
20. ACHEM SR, DEVAULT KR: Recent developments in chest pain of undetermined origin. Curr. Gastroenterol. Rep. (2000) 2(3):201-209.
21. LAKER MK, COOKSON JC: Reflux oesophagitis and clozapine. Int. Clin. Psychopharmacol. (1997) 12(1):37-39. (Pubitemid 27171194)
22. LEE M, SHARIFI R: Oxybutynin-induced reflux esophagitis. DICP (1990) 24(6):583-585. (Pubitemid 20189001)
23. (2)-adrenergic agonist on lower esophageal function: a dose-response study. Chest (2001) 120(4):1184-1189. (Pubitemid 32960091)
24. WONG RK, MAYDONOVITCH C, GARCIA JE, JOHNSON LF, CASTELL DO: The effect of terbutaline sulfate, nitroglycerin, and aminophylline on lower esophageal sphincter pressure and radionuclide esophageal emptying in patients with achalasia. J. Clin. Gastroenterol. (1987) 9(4):386-389. (Pubitemid 17128195)
25. ISHIKAWA H, IWAKIRI K, SUGIURA T, KOBAYASHI M: Effect of nifedipine administration (10 mg) on esophageal acid exposure time. J. Gastroenterol. (2000) 35(1):43-46. (Pubitemid 30072280)
26. ALLEN M, MELLOW M, ROBINSON MG, ORR WC: Comparison of calcium channel blocking agents and an anticholinergic agent on oesophageal function. Aliment. Pharmacol. Ther. (1987) 1(2):153-159.
27. KIKENDALL JW, MELLOW MH: Effect of sublingual nitroglycerin and long-acting nitrate preparations on esophageal motility. Gastroenterology (1980) 79(4):703-706. (Pubitemid 10009561)
28. MATSUDA NM, OLIVEIRA RB, DANTAS RO, IAZIGI N: Effect of isosorbide dinitrate on gastroesophageal reflux in healthy volunteers and patients with Chagas' disease. Dig. Dis. Sci. (1995) 40(1):177-182.
29. STOSCHUS B, FERNANDEZ I, HELLER J, NEUBRAND M, SAUERBRUCH T: Prediction of the lower esophageal sphincter pressure after oral molsidomine by sydnonimine plasma concentrations. Hepatogastroenterology (1999) 46(26):933-937. (Pubitemid 29224768)
30. WILLIS S, ALLESCHER HD, STOSCHUS B, SCHUSDZIARRA V, CLASSEN M, SCHUMPELICK V: Double blind placebo controlled study on the effect of the nitric oxide donor molsidomin and the 5-HT3 antagonist ondansetron on human esophageal motility. Z. Gastroenterol. (1994) 32(11):632-636. (Pubitemid 24372748)
31. KADAKIA SC, KIKENDALL JW, MAYDONOVITCH C, JOHNSON LF: Effect of cigarette smoking on gastroesophageal reflux measured by 24-h ambulatory esophageal pH monitoring. Am. J. Gastroenterol. (1995) 90(10):1785-1790.
32. KADAKIA SC, DE LA BAUME HR, SHAFFER RT: Effects of transdermal nicotine on lower esophageal sphincter and esophageal motility. Dig. Dis. Sci. (1996) 41(11):2130-2134. (Pubitemid 26414431)
33. BORTOLOTTI M, PANDOLFO N, GIOVANNINI M, MARI C, MIGLIOLI M: Effect of sildenafil on hypertensive lower oesophageal sphincter. Eur. J. Clin. Invest. (2002) 32(9):682-685. (Pubitemid 36223398)
34. RHEE PL, HYUN JG, LEE JH et al.: The effect of sildenafil on lower esophageal sphincter and body motility in normal male adults. Am. J. Gastroenterol. (2001) 96(12):3251-3257. (Pubitemid 34016645)
35. BORTOLOTTI M, MARI C, GIOVANNINI M, PINNA S, MIGLIOLI M, PANDOLFO N: Effects of sildenafil on esophageal motility of normal subjects. Dig. Dis. Sci. (2001) 46(11):2301-2306. (Pubitemid 33042324)
36. EHERER AJ, SCHWETZ I, HAMMER HF et al.: Effect of sildenafil on oesophageal motor function in healthy subjects and patients with oesophageal motor disorders. Gut (2002) 50(6):758-764. (Pubitemid 34539035)
37. MOREIRA SG Jr, BRANNIGAN RE, SPITZ A, OREJUELA FJ, LIPSHULTZ LI, KIM ED: Side-effect profile of sildenafil citrate (Viagra) in clinical practice. Urology (2000) 56(3):474-476. (Pubitemid 30658181)
38. JOHANNESSON N, ANDERSSON KE, JOELSSON B, PERSSON CG: Relaxation of lower esophageal sphincter and stimulation of gastric secretion and diuresis by antiasthmatic xanthines. Role of adenosine antagonism. Am. Rev. Respir. Dis. (1985) 131(1):26-30.
39. BERQUIST WE, RACHELEFSKY GS, KADDEN M et al.: Effect of theophylline on gastroesophageal reflux in normal adults. J. Allergy Clin. Immunol. (1981) 67(5):407-411. (Pubitemid 11105968)
40. DUKES MNG: Meyler's side effects of drugs (13th edn), Elsevier, Amsterdam (1996):375,540,595.
41. ENZENAUER RW, BASS JW, MCDONNELL JT: Esophageal ulceration associated with oral theophylline. N. Engl. J. Med. (1984) 26;310(4):261. (Pubitemid 14221969)
42. COTTON BR, SMITH G, FELL D: Effect of oral diazepam on lower oesophageal sphincter pressure. Br. J. Anaesth. (1981) 53(11):1147-1150. (Pubitemid 12235852)
43. WEIHRAUCH TR, FORSTER CF, KOHLER H, EWE K, KRIEGLSTEIN J: Effect of intravenous diazepam on human lower oesophageal sphincter pressure under controlled double blind crossover conditions. Gut (1979) 20(1):64-67. (Pubitemid 9134521)
44. SIMKO V, JOSEPH D, MICHAEL S: Increased risk in esophageal obstruction with slow-release medications. J. Assoc. Acad. Minor. Phys. (1997) 8(2):38-42.
45. BOYCE HW: Drug-induced esophageal and gastric damage. In: Current topics in gastroenterology and hepatology. Tytgat GNJ, van Blankenstein M (Eds), Georg Thieme, New York (1996):170-195.
46. KIKENDALL JW: Pill-induced esophageal injury. Gastroenterol. Clin. North Am. (1991) 20(4):835-846.
47. KIKENDALL JW, FRIEDMAN AC, OYEWOLE MA: Pill-induced esophageal injury: case reports and review of the medical literature. Dig. Dis. Sci. (1983) 28(2):174-182. (Pubitemid 13190098)
48. BOTT S, PRAKASH C, MCCALLUM RW: Medication-induced esophageal injury: survey of the literature. Am. J. Gastroenterol. (1987) 82(8):758-763. (Pubitemid 17145104)
49. MASON SJ, O'MEARA TF: Drug-induced esophagitis. J. Clin. Gastroenterol. (1981) 3(2):115-120. (Pubitemid 11113497)
50. CARLBORG B, DENSERT O: Esophageal lesions caused by orally administered drugs. An experimental study in the cat. Eur. Surg. Res. (1980) 12(4):270-282. (Pubitemid 11207556)
51. O'MEARA TF: A new endoscopic finding of tetracycline-induced oesophageal ulcers. Gastrointest. Endosc. (1980) 26(3):106-107. (Pubitemid 10040334)
52. BURKE EL: Acute oesophageal damage from one brand of tetracycline tablets. Gastroenterology (1975) 68:1022.
53. STILLMAN AE, MARTIN RJ: Tetracycline-induced oesophageal ulcerations. Arch. Dermatol. (1979) 115(8):1005.
54. AARONS B, BRUNS BJ: Oesophageal ulceration associated with ingestion of doxycycline. NZ Med. J. (1980) 91(651):27. (Pubitemid 10127251)
55. CARLBORG B, DENSERT O, LINDQVIST C: Tetracycline induced esophageal ulcers. A clinical and experimental study. Laryngoscope (1983) 93(2):184-187. (Pubitemid 13187457)
56. FRASER GM, ODES HS, KRUGLIAK P: Severe localised oesophagitis due to doxycycline. Endoscopy (1987) 19(2):86. (Pubitemid 17043125)
57. BELL RJ: Tetracycline induced esophagitis. Ala. Med. (1986) 50:47-50.
58. AL-MOFARREH MA, AL MOFLEH IA: Esophageal ulceration complicating doxycycline therapy. World J. Gastroenterol. (2003) 9(3):609-611. (Pubitemid 36372137)
59. ECKER GA, KARSCH J: Naproxen induced ulcerative esophagitis. J. Rheumatol. (1992) 19(4):646-647.
60. MCCORD GS, CLOUSE RE: Pill-induced oesophageal stricture: clinical features and risk factors for development. Am. J. Med. (1990) 88(5):512-518. (Pubitemid 20168728)
61. TAHA A, DAHILL S, NAKSHABENDI L, LEE FD, STURROCK RD, RUSSELL RI: Oesophageal histology in long term users of non-steroidal anti-inflammatory drugs. J. Clin. Path. (1994) 47(8):705-708.
62. TALLEY NJ, EVANS JM, FLEMING KC, HARMSEN WS, ZINSMEISTER AR, MELTON LJ: Nonsteroidal antiinflammatory drugs and dyspepsia in the elderly. Dig. Dis. Sci. (1995) 40(6):1345-1350.
63. EL-SERAG HB, SONNENBERG A: Association of esophagitis and esophageal strictures with diseases treated with nonsteroidal anti-inflammatory drugs. Am. J. Gastroenterol. (1997) 92(1):52-56. (Pubitemid 27027028)
64. ISLER M, BAHCECI M: Cataflam-induced esophageal ulceration. Am. J. Gastroenterol. (2001) 96(4):1300-1301.
65. LEVINE MS, BORISLOW SM, RUBESIN SE, O'BRIEN C: Esophageal stricture caused by a motrin tablet (ibuprofen). Abdom. Imaging (1994) 19(1):6-7. (Pubitemid 24007597)
66. SUGAWA C, TAKEKUMA Y, LUCAS CE, AMAMOTO H: Bleeding esophageal ulcers caused by NSAIDs. Surg. Endosc. (1997) 11(2):143-146. (Pubitemid 127523126)
67. MINOCHA A, GREENBAUM DS: Pill-esophagitis caused by nonsteroidal antiinflammatory drugs. Am. J. Gastroenterol. (1991) 86(8):1086-1089.
68. KATSINELOS P, DIMIROPOULOS S, VASILIADIS T, FOTIADIS G, XIARCHOS P, EUGENIDIS N: Oesophageal ulceration associated with ingestion of mefenamic acid capsules. Eur. J. Gastroenterol. Hepatol. (1999) 11(12):1431-1432. (Pubitemid 30009353)
69. SCHREIBER JB, COVINGTON JA: Aspirin-induced oesophageal hemorrhage. JAMA (1988) 259(11):1647-1648.
70. KIM SL, HUNTER JG, WO JM, DAVIS LP, WARING JP: NSAIDs, aspirin, and esophageal strictures: are over-the-counter medications harmful to the esophagus? J. Clin. Gastroenterol. (1999) 29(1):32-34. (Pubitemid 29288199)
71. BAATAR D, JONES MK, PAI R et al.: Selective cyclooxygenase-2 blocker delays healing of esophageal ulcers in rats and inhibits ulceration-triggered c-Met/hepatocyte growth factor receptor induction and extracellular signal-regulated kinase 2 activation. Am. J. Pathol. (2002) 160(3):963-972. (Pubitemid 34224585)
72. SCHMASSMANN A, PESKAR BM, STETTLER C et al.: Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastrointestinal ulcer models in rats. Br. J. Pharmacol. (1998) 123(5):795-804. (Pubitemid 28085378)
73. KAUR BS, KHAMNEHEI N, IRAVANI M, NAMBURU SS, LIN O, TRIADAFILOPOULOS G: Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. Gastroenterology (2002) 123(1):60-67. (Pubitemid 34747526)
74. SCHEIMAN JM, PATEL PM, HENSON EK, NOSTRANT TT: Effect of naproxen on gastroesophageal reflux and esophageal function: a randomized, double-blind, placebo-controlled study. Am. J. Gastroenterol. (1995) 90(5):754-757.
75. GRAHAM DY: What the gastroenterologist should know about the gastrointestinal safety profiles of bisphosphonates. Dig. Dis. Sci. (2002) 47(8):1665-1678. (Pubitemid 34833194)
76. ALVARES JF, KULKARNI SG, BHATIA SJ, DESAI SA, DHAWAN PS: Prospective evaluation of medication-induced esophageal injury and its relation to esophageal function. Indian J. Gastroenterol. (1999) 18(3):115-117. (Pubitemid 29304969)
77. NEWTON M, KAMM MA, QUIGLEY T, BURNHAM WR: Symptomatic gastroesophageal reflux in acutely hospitalized patients. Dig. Dis. Sci. (1999) 44(1):140-148. (Pubitemid 29053090)
78. AVIDAN B, SONNENBERG A, SCHNELL TG, SONTAG SJ: Risk factors for erosive reflux esophagitis: a case-control study. Am. J. Gastroenterol. (2001) 96(1):41-46. (Pubitemid 32104805)
79. LANAS A, HIRSCHOWITZ BI: Significance of aspirin use in patients with esophagitis. J. Clin. Gastroenterol. (1991) 13(6):622-627.
80. HELLER SR, FELLOWS IW, OGILVIE AL, ATKINSON M: Non-steroidal anti-inflammatory drugs and benign oesophageal stricture. Br. Med. J. (Clin. Res. Ed.) (1982) 285:(6336)167-168. (Pubitemid 12079066)
81. WILKINS WE, RIDLEY MG, POZNIAK AL: Benign strictures of the oesophagus: role of non-steroidal anti-inflammatory drugs. Gut (1984) 25(5):478-480. (Pubitemid 14144020)
82. KIKENDALL JW, SCHMIDT M, GRAEBER GM: Pill-induced esophageal ulceration and stricture following cardiac surgery. Milit. Med. (1986) 151(10):539-542. (Pubitemid 17195489)
83. SHALLCROSS TM, WYATT JI, RATHHONE BJ, HEATLY RV: Non-steroidal anti-inflammatory drugs, hiatus hernia, and Helicobacter pylori, in patients with oesphageal ulceration. Br. J. Rheumatol. (1990) 29(4):288-290. (Pubitemid 20226543)
84. SUN DCH, ROTH SH, MITCHELL CS, ENGLIND DW: Upper gastrointestinal disease in rheumatoid arthritis. Am. J. Dig. Dis. (1974) 19(5):405-410.
85. SEMBLE EL, WU WC, CASTELL DO: Nonsteroidal antiinflammatory drugs and esophageal injury. Semin. Arthritis Rheum. (1989) 19(2):99-109. (Pubitemid 19269475)
86. WILCOX CM, SHALEK KA, COTSONIS G: Striking prevalence of over-the-counter-nonsteroidal anti-inflammatory drug use in patients with upper gastrointestinal hemorrhage. Arch. Intern. Med. (1994) 154(1):42-46. (Pubitemid 24018100)
87. DE LEDINGHEN V, MANNANT PR, FOUCHER J et al.: Non-steroidal anti-inflammatory drugs and variceal bleeding: a case-control study. J. Hepatol. (1996) 24(5):570-573. (Pubitemid 26168639)
88. PERKINS AC, WILSON CG, FRIER M et al.: Esophageal transit of risedronate cellulose-coated tablet and gelatin capsule formulations. Int. J. Pharm. (1999) 186(2):169-175. (Pubitemid 29459044)
89. CRETEUR V, LAUFER I, KRESSEL HY et al.: Drug-induced oesophagitis detected by double-contrast radiography. Radiology (1983) 147(2):365-368. (Pubitemid 13133203)
90. COLINA RE, SMITH M, KIKENDALL JW, WONG RKH: A new probable increasing cause of esophageal ulceration: alendronate. Am. J. Gastroenterol. (1997) 92(4):704-706. (Pubitemid 27184396)
91. DE GROEN PC, LUBBE DF, HIRSCH LJ et al.: Esophagitis associated with the use of alendronate. N. Engl. J. Med. (1996) 335(14):1016-1021. (Pubitemid 26338731)
92. GRAHAM DY, MALATY HM, GOODGAME R: Primary amino-biphosphonates: a new class of gastrotoxic drugs-comparison of alendronate and aspirin. Am. J. Gastroenterol. (1997) 92(8):1322-1325.
93. LANZA FL, CARLSON MR: The effects of amino versus alkyl-biphosphonates on the healing of aspirin-induced stomach erosions in healthy subjects. Am. J. Gastroenterol. (1996) 91:1916.
94. ADAMI S, MIAN M, GATTI P et al.: Effects of two oral doses of alendronate in the treatment of Paget's disease of bone. Bone (1994) 15(4):415-417. (Pubitemid 24168014)
95. BLANK MA, EMS BL, GIBSON GW et al.: Nonclinical model for assessing gastric effects of bisphosphonates. Dig. Dis. Sci. (1997) 42(2):281-288. (Pubitemid 27112971)
96. FRANCIS RM: Oral bisphosphonates in the treatment of osteoporosis: a review. Curr. Ther. Res. (1995) 56:831-851.
97. LIBERMAN, UA, HIRSCH LJ: Esophagitis and alendronate. N. Engl. J. Med. (1996) 335(14):1069-1070.
98. MACONI G, PORRO GB: Multiple ulcerative oesophagitis caused by alendronate. Am. J. Gastroenterol. (1995) 90(10):1889-1890.
99. ABDELMALEK MF, DOUGLAS DD: Alendronate-induced ulcerative oesophagitis. Am. J. Gastroenterol. (1996) 91(6):1282-1283. Letter.
100. PETER CP, HANDT LK, SMITH SM: Esophageal irritation due to alendronate sodium tablets: possible mechanisms. Dig. Dis. Sci. (1998) 43(9):1998-2002.
101. VAN STAA T, ABENHAIM L, COOPER C: Upper gastrointestinal adverse events and cyclical etidronate. Am. J. Med. (1997) 103(6):462-467. (Pubitemid 28018647)
102. LARSEN KO, STRAY N, ENGH V, SANDNES D: Esophageal lesions associated with diphosphonates. Tidsskr. Nor. Laegeforen. (2000) 120(20):2397-2399.
103. MACEDO G, AZEVEDO F, RIBEIRO T: Ulcerative esophagitis caused by etidronate. Gastrointest. Endosc. (2001) 53(2):250-251. (Pubitemid 32147619)
104. MAROY B: Giant esophageal ulcer probably due to etidronate. Gastroenterol. Clin. Biol. (2001) 25(10):917-918. (Pubitemid 33062857)
105. THOMSON AB, MARSHALL JK, HUNT RH et al.: 14 day endoscopy study comparing risedronate and alendronate in postmenopausal women stratified by Helicobacter pylori status. J. Rheumatol. (2002) 29(9):1965-1974. (Pubitemid 34988708)
106. LANZA FL, HUNT RH, THOMSON AB, PROVENZA JM, BLANK MA: Endoscopic comparison of esophageal and gastroduodenal effects of risedronate and alendronate in postmenopausal women. Gastroenterology (2000) 119(3):631-638.
107. LANZA F, SCHWARTZ H, SAHBA B et al.: An endoscopic comparison of the effects of alendronate and risedronate on upper gastrointestinal mucosae. Am. J. Gastroenterol. (2000) 95(11):3112-3117.
108. BONE HG, ADAMI S, RIZZOLI R et al.: Weekly administration of alendronate: rationale and plan for clinical assessment. Clin. Ther. (2000) 22(1):15-28. (Pubitemid 30091420)
109. SCHNITZER T, BONE HG, CREPALDI G et al.: Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group. Aging (Milano) (2000) 12(1):1-12. (Pubitemid 30136655)
110. PEMBERTON J: Oesophageal obstruction and ulceration caused by oral potassium therapy. Br. Heart J. (1970) 32(2):267-268.
111. ROSENTHAL T, ADAR R, MILILTIANU J: Oesophageal ulceration and oral potassium chloride ingestion. Chest (1974) 65(4):463-465.
112. HENRY JG, SHINNER JJ, MARTINO JH: Fatal oesophageal and bronchial artery ulceration caused by solid potassium chloride. Pediatr. Cardiol. (1983) 4(3):251-252. (Pubitemid 14212373)
113. LUBBE WF, CADOGAN ES, KANNEMEYER AHR: Oesophageal ulceration due to slow-release potassium in the presence of left atrial enlargement. NZ Med. J. (1979) 90(647):377-379. (Pubitemid 10126104)
114. TEPLICK JG, TEPLICK SK, OMINSKY SH, HASKIN ME: Esophagitis caused by oral medication. Radiology (1980) 134(1):23-25. (Pubitemid 10161324)
115. MARVOLA M, RAJANIEMI M, MARTTILA E, VAHERVUO K, SOTHMANN A: Effect of dosage form and formulation factors on the adherence of drugs to the esophagus. J. Pharm. Sci. (1983) 72(9):1034-1036. (Pubitemid 13003521)
116. EVANS KT, TOBERTS GM: Where do all the tables go? Lancet (1976) 2:1237-1239.
117. BONAVINA L, DEMEESTER TR, MCCHESNEY L, SCHWIZER W, ALBERTUCCI M, BAILEY RT: Drug-induced esophageal strictures. Ann. Surg. (1987) 206(2):173-183. (Pubitemid 17104961)
118. APPLEGATE GR, MALMUD LS, ROCK E: 'It's a hard pill to swallow' or 'Don't take it lying down'. Gastroenterology (1980) 78:1132.
119. SOPENA F, LANAS A, SAINZ R: Esophageal motility and intraesophageal pH patterns in patients with esophagitis and chronic nonsteroidal anti-inflammatory drug use. J. Clin. Gastroenterol. (1998) 27(4):316-320. (Pubitemid 28547469)
120. SHERMAN A, BINI EJ: Pill-induced gastric injury. Am. J. Gastroenterol. (1999) 94(2):511-613.
121. HIGUCHI K, ANDO K, KIM SR et al.: Sildenafil-induced esophageal ulcers. Am. J. Gastroenterol. (2001) 96(8):2516-2518.
122. PINOS T, FIGUERAS C, MAR R: Doxycycline-induced oesophagitis: treatment with liquid sucralphate. Am. J. Gastroenterol. (1990) 85(7):902-903.
123. BERNABEU-WITTEL M, NARANJO M, CISNEROS JM et al.: Infections in renal transplant recipients receiving mycophenolate versus azathioprine-based immunosuppression. Eur. J. Clin. Microbiol. Infect. Dis. (2002) 21(3):173-180. (Pubitemid 34328001)
124. OLOVSON SG, BJÖRKMAN JA, EK L, HAVU N: The ulcerogenic effect on the oesophagus of three ?-adrenoceptor antagonists, investigated in a new porcine oesophagus test model. Acta Pharmacol. Toxicol. (Copenh.) (1983) 53(5):385-391. (Pubitemid 14231148)
125. THORPE JA: Effect of propranolol on the lower oesophageal sphincter in man. Curr. Med. Res. Opin. (1980) 7(2):91-95. (Pubitemid 11161034)
126. LYRENAS E, ABRAHAMSSON H: adrenergic influence on oesophageal peristalsis in man. Gut (1986) 27(3):260-266. (Pubitemid 16101895)
127. WALTA DC, GIDDENS JD, JOHNSON LF, KELLEY JL, WAUGH DF: Localized proximal esophagitis secondary to ascorbic acid ingestion and esophageal motor disorder. Gastroenterology (1976) 70(5,1):766-769.
128. SUTTON DR, GOSNOLD JK: Oesophageal ulceration due to clindamycin. Br. Med. J. (1977) 1(6076):1598.
129. ABRAHAM SC, YARDLEY JH, WU TT: Erosive injury to the upper gastrointestinal tract in patients receiving iron medication: an underrecognized entity. Am. J. Surg. Pathol. (1999) 23(10):1241-1247.
130. RUDOLPH R, SEGGEWISS H, SECKFORT H: Esophageal ulcer caused by mexiletine. Dtsch. Med. Wochenschr. (1983) 108(26):1018-1020.
131. PENALBA C: Esophageal ulcerations induced by mexiletine hydrochloride. Ann. Gastroenterol. Hepatol. (Paris) (1986) 22(5):267-268. (Pubitemid 17203289)
132. ADLER JB, GOLDBERG RI: Mexiletine-induced pill esophagitis. Am. J. Gastroenterol. (1990) 85(5):629-630. (Pubitemid 20164340)
133. MCCLOY EC, KANE S: Drug-induced oesophageal ulceration. Br. Med. J. (Clin. Res. Ed.) (1981) 282(6277):1703. (Pubitemid 11111313)
134. RAMBOER C, VERHAMME M: D-penicillamine-induced oesophageal ulcers. Acta Clin. Belg. (1989) 44(3):189-191. (Pubitemid 19252690)
135. LOFT DE, STUBINGTON S, CLARK C, REES WD: Oesophageal ulcer caused by warfarin. Postgrad. Med. J. (1989) 65(762):258-259. (Pubitemid 19097183)
136. ANDRESS M: Submucosal haematoma of the oesophagus due to anticoagulant therapy. Report of a case. Acta Radiol. Diagn. (Stockh.) (1971) 11(2):216-219.
137. SMART RF, STONE AR: Intramural oesophageal haematoma complicating anticoagulant therapy. NZ Med. J. (1978) 87(607):176-177. 509-511