Laboratory Diagnosis of Heparin-Induced Thrombocytopenia in Asian Indians as Investigated with Functional and Immunologic Methods

Clinical and Applied Thrombosis/Hemostasis

Volumn 10, Issue 1, 2004, Pages 51-54

  Kannan, Meganathan ^a   Ahmed, Rafeeq ^a   Kale, Shailaja ^a   Ahmad, Sarfraz ^b,c   Fareed, Jawed ^b   Saxena, Renu ^a,d  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c FLORIDA HOSPITAL CANCER INSTITUTE   (United States)

^d INSTITUTE ROTARY CANCER HOSPITAL   (India)

Author keywords

Anti heparin PF4 antibodies; Asian Indian subjects; Functional assay; Heparin induced thrombocytopenia; Immunologic assay; Unfractionated heparin

Indexed keywords

ANTIBODY; HEPARIN; HEPARIN ANTIBODY; THROMBOCYTE FACTOR 4; THROMBOCYTE FACTOR 4 ANTIBODY; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; BLEEDING; CARDIOVASCULAR SURGERY; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; INDIAN; LABORATORY DIAGNOSIS; MALE; PRIORITY JOURNAL; SCHOOL CHILD; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTOPENIA;

EID: 2142765249     PISSN: 10760296     EISSN: None     Source Type: Journal    
DOI: 10.1177/107602960401000108     Document Type: Article

References (16)

1. King DJ, Kelton JG. Heparin-associated thrombocytopenia. Ann Intern Med 1984;100:535.
2. Elalamy I, Lecrubier C, Horellou MH, Conard J, Samama MM. Heparin-induced thrombocytopenia: Laboratory diagnosis and management. Ann Med 2000;32(Suppl 1):60.
3. Fabris F, Ahmad S, Cella G, Jeske WP, Walenga JM, Fareed J. Pathophysiology of heparin-induced thrombocytopenia: Clinical and diagnostic implications-a review. Arch Pathol Lab Med 2000;124:1657.
4. Ahmad S, Untch B, Haas S, Hoppensteadt DA, Misselwitz F, Messmore HL, Walenga JM, Fareed F. Differential prevalence of anti-heparin-PF4 immunoglobulin subtypes in patients treated with clivarin and heparin: Implications in the HIT pathogenesis. Mol Cell Biochem 2003, in press.
5. Blinder MA. Heparin-induced thrombocytopenia. Lab Med Newslett 2002;8(2):1.
6. Warkentin TE, Kelton JG. Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med 2001;135:502.
7. Warkentin TE. Heparin-induced thrombocytopenia: A 10-year retrospective study. Annu Rev Med 1999;50:129.
8. Amiral J, Marfaing-Koka A, Poncz M, Meyer D. The biological basis of immune heparin-induced thrombocytopenia. Platelets 1998;9:77.
9. Chong BH. Heparin-induced thrombocytopenia. Br J Haematol 1995;89:431.
10. Bachelot-Loza C, Saffroy R, Lasne D, Chatellier G, Aiach M, Rendu F. Importance of the FcγRIIa-Arg/His-131 polymorphism in heparin-induced thrombocytopenia diagnosis. Thromb Haemost 1998;79:523.
11. Walenga JM, Jeske WP, Wood JJ, Ahmad S, Lewis BE, Bakhos M. Laboratory tests for heparin-induced thrombocytopenia: A multicenter study. Semin Hematol 1999; 36(Suppl 1):22.
12. Nand S, Wong W, Yuen B, Yetter A, Schmulbach E, Gross Fisher S. Heparin-induced thrombocytopenia with thrombosis: Incidence, analysis of risk factors, and clinical outcomes in 108 consecutive patients treated at a single institution. Am J Hematol 1997;156:12.
13. Sheridan D, Carter C, Kelton JG. A diagnostic test for heparin-induced thrombocytopenia. Blood 1986;67:27.
14. Harenberg J, Huhle G, Giese C, Wang LC, Feuring M, Song XH, Hoffmann U. Determination of serotonin release from platelets by enzyme immunoassay in the diagnosis of heparin-induced thrombocytopenia. Br J Haematol 2000;109:182.
15. Osumi K, Ozeki Y, Saito S, Nagamura Y, Ito H, Kimura Y, Ogura H, Nomura S. Development and assessment of enzyme immunoassay for platelet-derived microparticles. Thromb Haemost 2001;85:326.
16. Walenga JM, Jeske WP, Fasanella AR, Wood JJ, Ahmad S, Bakhos M. Laboratory diagnosis of heparin-induced thrombocytopenia. Clin Appl Thromb Hemost 1999; 5(Suppl 1):S21.