Determination of serotonin release from platelets by enzyme immunoassay in the diagnosis of heparin-induced thrombocytopenia

British Journal of Haematology

Volumn 109, Issue 1, 2000, Pages 182-186

  Harenberg, J ^a   Huhle, G ^a   Giese, C H ^a   Wang, L C ^a   Feuring, M ^b   Song, X H ^a   Hoffmann, U ^a  

^a Faculty of Clinical Medicine Mannheim of the Ruprecht Karls University of Heidelberg   (Germany)

^b University Hospital   (Germany)

Author keywords

Enzyme immunoassay; Heparin induced thrombocytopenia; Serotonin; Thrombocytopenia; Thrombosis

Indexed keywords

DANAPAROID; HEPARIN;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DRUG INDUCED DISEASE; ENZYME IMMUNOASSAY; HUMAN; INTERMETHOD COMPARISON; PRIORITY JOURNAL; SEROTONIN RELEASE; THROMBOCYTOPENIA;

ANTICOAGULANTS; BLOOD PLATELETS; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; IMMUNOENZYME TECHNIQUES; PREDICTIVE VALUE OF TESTS; SENSITIVITY AND SPECIFICITY; SEROTONIN; THROMBOCYTOPENIA;

EID: 0034038495     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2000.01966.x     Document Type: Article

References (19)

1. Amiral, J., Bridley, F., Dreyfus, M., Vissac, A.M., Freyssinnaud, E., Wolf. M. & Meyer, D. (1992) Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thrombosis and Haemostasis, 68, 95-96.
2. Amiral, J., Bridey, F., Wolf, M., Boyer-Neuman, C., Fressinaund, E., Vissac, A.M., Peynaud-Dabyle, E., Dreyfus, M. & Meyer, D. (1995) Antibodies to macromolecular platelet factor 4-heparin complexes in heparin-induced thrombocytopenia: a study of 44 cases. Thrombosis and Haemostasis, 73, 21-28.
3. Arepally, G., Reynolds, C., Tomaski, A., Amiral, J., Jawad, A., Poncz, M. & Cines, D.B. (1995) Comparison of PF4/heparin ELISA assay with the 14C-serotonin release assay in the diagnosis of heparin-induced thrombocytopenia. American Journal of Clinical Pathology, 104, 648-654.
4. Chong, B.H. (1995) Heparin-induced thrombocytopenia. British Journal of Haematology, 89, 431-439.
5. Greinacher, A., Michels, I., Kiefel, V. & Mueller-Eckhardt, C. (1991) A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thrombosis and Haemostasis, 66, 734-736.
6. Greinacher, A., Pötzsch, B., Amiral, J., Dummel, V., Eichner, A. & Mueller-Eckhardt, C. (1994a) Heparin-associated thrombocytopenia. Isolation of the antibody and characterization of a multimolecular PF4-heparin complex as the major antigen. Thrombosis and Haemostasis, 71, 247-251.
7. Greinacher, A., Amiral, J., Dummel, V., Vissaqc, A., Kiefel, V. & Mueller-Eckhardt, C. (1994b) Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet faetor 4/heparin enzyme-linked immunosorbant assay. Transfusion, 34, 381-385.
8. Hrycaj, P., Stratz, T., Mennet, P. & Muller, W. (1996) Pathogenetic aspects of responsiveness to ordansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome - a preliminary study. Journal of Rheumatology, 23, 1418-1423.
9. Kelton, J.G., Sheridan, D., Santos, A., Smith, J., Sleeves, K., Smith, C., Brown, C. & Murphy, W.G. (1988) Heparin-induced thrombocytopenia: laboratory studies. Blood, 72, 925-930.
10. Lee, D.H., Warkentin, T.E., Denmme, G.A., Hayward, C.P.M. & Kelton, J.G. (1996) A diagnostic test for heparin-induced thrombocytopenia: detection of platelet microparticles using flow cytometry. British Journal of Haematology, 95, 724-731.
11. Magnani, H.N. (1993) Heparin-induced thrombocytopenia: an overview of 230 patients treated with Orgaran (Org 10172). Thrombosis and Haemostasis, 70, 554-561.
12. Metz, C.E. (1978) Basic principles of ROC analysis. Seminars in Nuclear Medicine, 8, 283-298.
13. Newman, P.M., Swanson, R.L & Chong. B.H. (1998) Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross-reactivity with low-molccular-weight heparin and heparinoid. Thrombosis and Haemostasis, 80, 292-297.
14. Sheridan, D., Carter, C. & Kelton, J.G. (1986) A diagnostic test for heparin-induced thrombocytopenia. Blood, 67, 27-30.
15. Tomer, A. (1997) A sensitive and specific functional flow cytometric assay for the diagnosis of heparin-induced thrombocytopenia. British Journal of Haematology, 98, 648-656.
16. Wang, L.C., Huhle, G., Malsch, R., Hoffmann, U., Song, X.H. & Harenberg, J. (1999a) Determination of heparin-induced IgG antibody by fluorescence-linked immunofiltration assay (FLIFA). Journal of Immunological Methods, 222, 93-99.
17. Wang, L.C., Huhle, G., Hoffmann, U., Song, X.H. & Harenberg, J. (1999b) Determination of heparin-induced IgG antibody in heparin-induced thrombocytopenia type II. European Journal of Clinical Investigation, 29, 232-237.
18. Warkentin, T.E., Chong, B.H. & Greinacher, A. (1998) Heparin-induced thrombocytopenia: towards consensus. Thrombosis and Haemostasis, 79, 1-7.
19. Yporen, L., Liz, Q., Park, K.S., Sabnekar, P., Liu, W.Y., Arepally, G., Shoenfeld, Y., Kieber-Emmons, T., Cines, D.B. & Poncz, M. (1998) Defining an antigen on platelet factor 4 with heparin-induced thrombocytopenia. Blood, 92, 3250-3259.