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Volumn 50, Issue , 1999, Pages 129-147

Heparin-induced thrombocytopenia: A ten-year retrospective

Author keywords

Antibody; Danaparoid; Hirudin; Thrombin; Thrombosis

Indexed keywords

ANTICOAGULANT AGENT; DANAPAROID; FC RECEPTOR; HEPARIN; IMMUNOGLOBULIN G ANTIBODY; LEPIRUDIN; PROCOAGULANT; THROMBIN; THROMBOCYTE FACTOR 4; THROMBOCYTE RECEPTOR; WARFARIN;

EID: 0032977821     PISSN: 00664219     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.med.50.1.129     Document Type: Review
Times cited : (124)

References (59)
  • 2
    • 0029035681 scopus 로고
    • Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin
    • 2. Warkentin TE, Levine MN, Hirsh J, et al. 1995. Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N. Engl. J. Med. 332: 1330-35
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1330-1335
    • Warkentin, T.E.1    Levine, M.N.2    Hirsh, J.3
  • 3
    • 0030281338 scopus 로고    scopus 로고
    • A 14-year study of heparin-induced thrombocytopenia
    • 3. Warkentin TE, Kelton JG. 1996. A 14-year study of heparin-induced thrombocytopenia. Am. J. Med. 101:502-7
    • (1996) Am. J. Med. , vol.101 , pp. 502-507
    • Warkentin, T.E.1    Kelton, J.G.2
  • 4
    • 0030983928 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia with thrombosis: Incidence, analysis of risk factors, and clinical outcomes in 108 consecutive patients treated at a single institution
    • 4. Nand S, Wong W, Yuen B, et al. 1997. Heparin-induced thrombocytopenia with thrombosis: incidence, analysis of risk factors, and clinical outcomes in 108 consecutive patients treated at a single institution. Am. J. Hematol. 56:12-16
    • (1997) Am. J. Hematol. , vol.56 , pp. 12-16
    • Nand, S.1    Wong, W.2    Yuen, B.3
  • 5
    • 0030702032 scopus 로고    scopus 로고
    • The pathogenesis of venous limb gangrene associated with heparin-induced thrombocytopenia
    • 5. Warkentin TE, Elavathil LJ, Hayward CPM, et al. 1997. The pathogenesis of venous limb gangrene associated with heparin-induced thrombocytopenia. Ann. Intern. Med. 127:804-12
    • (1997) Ann. Intern. Med. , vol.127 , pp. 804-812
    • Warkentin, T.E.1    Elavathil, L.J.2    Hayward, C.P.M.3
  • 6
    • 0029852157 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: IgG-mediated platelet activation, platelet microparticle generation, and altered procoagulant/anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia
    • 6. Warkentin TE. 1996. Heparin-induced thrombocytopenia: IgG-mediated platelet activation, platelet microparticle generation, and altered procoagulant/anticoagulant balance in the pathogenesis of thrombosis and venous limb gangrene complicating heparin-induced thrombocytopenia. Transfus. Med. Rev. 10:249-58
    • (1996) Transfus. Med. Rev. , vol.10 , pp. 249-258
    • Warkentin, T.E.1
  • 7
    • 0026638091 scopus 로고
    • Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia
    • Letter
    • 7. Amiral J, Bridey F, Dreyfus M, et al. 1992. Platelet factor 4 complexed to heparin is the target for antibodies generated in heparin-induced thrombocytopenia. Thromb. Haemost. 68:95-96 (Letter)
    • (1992) Thromb. Haemost. , vol.68 , pp. 95-96
    • Amiral, J.1    Bridey, F.2    Dreyfus, M.3
  • 8
    • 0027971564 scopus 로고
    • Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: An explanation for the thrombotic complications of heparin-induced thrombocytopenia
    • 8. Warkentin TE, Hayward CPM, Boshkov LK, et al. 1994. Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia. Blood 84: 3691-99
    • (1994) Blood , vol.84 , pp. 3691-3699
    • Warkentin, T.E.1    Hayward, C.P.M.2    Boshkov, L.K.3
  • 9
    • 0031793866 scopus 로고    scopus 로고
    • Limitations of conventional treatment options for heparin-induced thrombocytopenia
    • 9. Warkentin TE. 1998. Limitations of conventional treatment options for heparin-induced thrombocytopenia. Semin. Hematol. 35(Suppl. 4): 17-25
    • (1998) Semin. Hematol. , vol.35 , Issue.SUPPL. 4 , pp. 17-25
    • Warkentin, T.E.1
  • 11
    • 0024449410 scopus 로고
    • The mechanism of heparin-induced platelet aggregation
    • 11. Chong BH, Ismail BH. 1989. The mechanism of heparin-induced platelet aggregation. Eur. J. Haematol. 43:245-51
    • (1989) Eur. J. Haematol. , vol.43 , pp. 245-251
    • Chong, B.H.1    Ismail, B.H.2
  • 14
    • 0023710994 scopus 로고
    • Heparin-induced thrombocytopenia: Laboratory studies
    • 14. Kelton JG, Sheridan D, Santos A, et al. 1988. Heparin-induced thrombocytopenia: laboratory studies. Blood 72: 925-30
    • (1988) Blood , vol.72 , pp. 925-930
    • Kelton, J.G.1    Sheridan, D.2    Santos, A.3
  • 15
    • 34547731585 scopus 로고    scopus 로고
    • Thrombocytopenia due to platelet destruction and hypersplenism
    • ed. R Hoffman, EJ Benz Jr, SJ Shattil, et al. New York: Churchill Livingstone. 3rd ed. In press
    • 15. Warkentin TE, Kelton JG. 1999. Thrombocytopenia due to platelet destruction and hypersplenism. In Hematology. Basic Principles and Practice, ed. R Hoffman, EJ Benz Jr, SJ Shattil, et al. New York: Churchill Livingstone. 3rd ed. In press
    • (1999) Hematology. Basic Principles and Practice
    • Warkentin, T.E.1    Kelton, J.G.2
  • 16
    • 0026529799 scopus 로고
    • Heparin-associated thrombocytopenia: The antibody is not heparin specific
    • 16. Greinacher A, Michels I, Mueller-Eckhardt C. 1992. Heparin-associated thrombocytopenia: the antibody is not heparin specific. Thromb. Haemost. 67: 545-49
    • (1992) Thromb. Haemost. , vol.67 , pp. 545-549
    • Greinacher, A.1    Michels, I.2    Mueller-Eckhardt, C.3
  • 17
    • 0028243705 scopus 로고
    • Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4
    • 17. Kelton JG, Smith JW, Warkentin TE, et al. 1994. Immunoglobulin G from patients with heparin-induced thrombocytopenia binds to a complex of heparin and platelet factor 4. Blood 83:3232-39
    • (1994) Blood , vol.83 , pp. 3232-3239
    • Kelton, J.G.1    Smith, J.W.2    Warkentin, T.E.3
  • 18
    • 0028009642 scopus 로고
    • Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells
    • 18. Visentin GP, Ford SE, Scott JP, et al. 1994. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J. Clin. Invest. 93:81-88
    • (1994) J. Clin. Invest. , vol.93 , pp. 81-88
    • Visentin, G.P.1    Ford, S.E.2    Scott, J.P.3
  • 19
    • 0001311160 scopus 로고    scopus 로고
    • Diagnostic testing for heparin-induced thrombocytopenia (HIT): An enhanced platelet factor 4 complex enzyme linked immunosorbent assay (PF4 ELISA)
    • Abstr.
    • 19. Collins JL, Aster RH, Moghaddam M, et al. 1997. Diagnostic testing for heparin-induced thrombocytopenia (HIT): an enhanced platelet factor 4 complex enzyme linked immunosorbent assay (PF4 ELISA). Blood 90(Suppl. 1):461a (Abstr.)
    • (1997) Blood , vol.90 , Issue.SUPPL. 1
    • Collins, J.L.1    Aster, R.H.2    Moghaddam, M.3
  • 20
    • 0026681184 scopus 로고
    • Heparin-associated thrombocytopenia in a patient treated with polysulphated chondroitin sulphate: Evidence for immunological crossreactivity between heparin and polysulphated glycosaminoglycan
    • 20. Greinacher A, Michels I, Schäfer M, et al. 1992. Heparin-associated thrombocytopenia in a patient treated with polysulphated chondroitin sulphate: evidence for immunological crossreactivity between heparin and polysulphated glycosaminoglycan. Br. J. Haematol. 81:252-54
    • (1992) Br. J. Haematol. , vol.81 , pp. 252-254
    • Greinacher, A.1    Michels, I.2    Schäfer, M.3
  • 21
    • 0028158034 scopus 로고
    • Pentosan polysulfate-induced thrombocytopenia and thrombosis
    • 21. Tardy-Poncet B, Tardy B, Grelac F, et al. 1994. Pentosan polysulfate-induced thrombocytopenia and thrombosis. Am. J. Hematol. 45:252-57
    • (1994) Am. J. Hematol. , vol.45 , pp. 252-257
    • Tardy-Poncet, B.1    Tardy, B.2    Grelac, F.3
  • 22
    • 0030825407 scopus 로고    scopus 로고
    • Chemokines
    • 22. Rollins BJ. 1997. Chemokines. Blood 90: 909-28
    • (1997) Blood , vol.90 , pp. 909-928
    • Rollins, B.J.1
  • 23
    • 8944247264 scopus 로고    scopus 로고
    • Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia
    • 23. Amiral J, Marfaing-Koka A, Wolf M, et al. 1996. Presence of autoantibodies to interleukin-8 or neutrophil-activating peptide-2 in patients with heparin-associated thrombocytopenia. Blood 88: 410-16
    • (1996) Blood , vol.88 , pp. 410-416
    • Amiral, J.1    Marfaing-Koka, A.2    Wolf, M.3
  • 24
    • 0031795614 scopus 로고    scopus 로고
    • Clinical presentation of heparin-induced thrombocytopenia
    • 24. Warkentin TE. 1998. Clinical presentation of heparin-induced thrombocytopenia. Semin. Hematol. 35 (Suppl. 4): 9-16
    • (1998) Semin. Hematol. , vol.35 , Issue.SUPPL. 4 , pp. 9-16
    • Warkentin, T.E.1
  • 25
    • 0019801715 scopus 로고
    • Heparin-induced thrombocytopenia: Effect of heparin platelet antibody on platelets
    • 25. Chong BH, Grace CS, Rozenberg MC. 1981. Heparin-induced thrombocytopenia: effect of heparin platelet antibody on platelets. Br. J. Haematol. 49:531-40
    • (1981) Br. J. Haematol. , vol.49 , pp. 531-540
    • Chong, B.H.1    Grace, C.S.2    Rozenberg, M.C.3
  • 26
    • 4243436860 scopus 로고
    • Generation of platelet-derived microparticles and procoagulant activity by IgG platelet agonists: Comparison with standard platelet agonists
    • Abstr.
    • 26. Warkentin TE, Sheppard JI, Santos AV. 1994. Generation of platelet-derived microparticles and procoagulant activity by IgG platelet agonists: comparison with standard platelet agonists. Blood 84 (Suppl. 1):528a (Abstr.)
    • (1994) Blood , vol.84 , Issue.SUPPL. 1
    • Warkentin, T.E.1    Sheppard, J.I.2    Santos, A.V.3
  • 27
    • 0023109003 scopus 로고
    • Immune endothelial-cell injury in heparin-associated thrombocytopenia
    • 27. Cines DB, Tomaski A, Tannenbaum S. 1987. Immune endothelial-cell injury in heparin-associated thrombocytopenia. N. Engl. J. Med. 316:581-89
    • (1987) N. Engl. J. Med. , vol.316 , pp. 581-589
    • Cines, D.B.1    Tomaski, A.2    Tannenbaum, S.3
  • 28
    • 0001777490 scopus 로고    scopus 로고
    • Antibodies associated with heparin-induced thrombocytopenia/thrombosis (HITP) recognize sites on platelet factor 4 (PF4) induced by the binding of linear polyanionic compounds
    • Abstr.
    • 28. Visentin GP, Moghaddam M, Aster RH. 1997. Antibodies associated with heparin-induced thrombocytopenia/thrombosis (HITP) recognize sites on platelet factor 4 (PF4) induced by the binding of linear polyanionic compounds. Thromb. Haemost. 77(Suppl.):362 (Abstr.)
    • (1997) Thromb. Haemost. , vol.77 , Issue.SUPPL. , pp. 362
    • Visentin, G.P.1    Moghaddam, M.2    Aster, R.H.3
  • 29
    • 0029086769 scopus 로고
    • Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia
    • 29. Greinacher A, Alban S, Dummel V, et al. 1995. Characterization of the structural requirements for a carbohydrate based anticoagulant with a reduced risk of inducing the immunological type of heparin-associated thrombocytopenia. Thromb. Haemost. 74:886-92
    • (1995) Thromb. Haemost. , vol.74 , pp. 886-892
    • Greinacher, A.1    Alban, S.2    Dummel, V.3
  • 30
    • 0029819851 scopus 로고    scopus 로고
    • The epitope specificity of heparin-induced thrombocytopenia
    • 30. Horsewood P, Warkentin TE, Hayward CPM, et al. 1996. The epitope specificity of heparin-induced thrombocytopenia. Br. J. Haematol. 95:161-67
    • (1996) Br. J. Haematol. , vol.95 , pp. 161-167
    • Horsewood, P.1    Warkentin, T.E.2    Hayward, C.P.M.3
  • 31
    • 0030258647 scopus 로고    scopus 로고
    • Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin: Platelet factor 4 complexes
    • 31. Visentin GP, Malik M, Cyganiak KA, et al. 1996. Patients treated with unfractionated heparin during open heart surgery are at high risk to form antibodies reactive with heparin:platelet factor 4 complexes. J. Lab. Clin. Med. 128:376-83
    • (1996) J. Lab. Clin. Med. , vol.128 , pp. 376-383
    • Visentin, G.P.1    Malik, M.2    Cyganiak, K.A.3
  • 32
    • 0031029432 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia and thrombosis: A prospective analysis of the incidence in patients with heart and cerebrovascular disease
    • 32. Kappers-Klunne MC, Boon DMS, Hop WCJ, et al. 1997. Heparin-induced thrombocytopenia and thrombosis: a prospective analysis of the incidence in patients with heart and cerebrovascular disease. Br. J. Haematol. 96:442-46
    • (1997) Br. J. Haematol. , vol.96 , pp. 442-446
    • Kappers-Klunne, M.C.1    Boon, D.M.S.2    Hop, W.C.J.3
  • 33
    • 0028028417 scopus 로고
    • Transient global amnesia associated with acute heparin-induced thrombocytopenia
    • 33. Warkentin TE, Hirte HW, Anderson DR, et al. 1994. Transient global amnesia associated with acute heparin-induced thrombocytopenia. Am. J. Med. 97:489-91
    • (1994) Am. J. Med. , vol.97 , pp. 489-491
    • Warkentin, T.E.1    Hirte, H.W.2    Anderson, D.R.3
  • 34
    • 0032406795 scopus 로고    scopus 로고
    • Intraoperative heparin flushes and subsequent acute heparin-induced thrombocytopenia
    • In press
    • 34. Ling E, Warkentin TE. 1998. Intraoperative heparin flushes and subsequent acute heparin-induced thrombocytopenia. Anesthesiology 89: In press
    • (1998) Anesthesiology , vol.89
    • Ling, E.1    Warkentin, T.E.2
  • 35
    • 4243212509 scopus 로고    scopus 로고
    • Timing of heparin-induced thrombocytopenia (HIT) in relation to previous heparin use: Absence of an anamnestic immune response, and implications for repeat heparin use in patients with a history of HIT
    • 35. Warkentin TE, Kelton JG. 1998. Timing of heparin-induced thrombocytopenia (HIT) in relation to previous heparin use: absence of an anamnestic immune response, and implications for repeat heparin use in patients with a history of HIT. Blood 92(Suppl. 1):182a
    • (1998) Blood , vol.92 , Issue.SUPPL. 1
    • Warkentin, T.E.1    Kelton, J.G.2
  • 36
    • 0030054018 scopus 로고    scopus 로고
    • Heparin-induced skin lesions
    • 36. Warkentin TE. 1996. Heparin-induced skin lesions. Br. J. Haematol 92:494-97
    • (1996) Br. J. Haematol , vol.92 , pp. 494-497
    • Warkentin, T.E.1
  • 37
    • 0001551531 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia, heparin-induced skin lesions, and arterial thrombosis
    • Abstr.
    • 37. Warkentin TE. 1997. Heparin-induced thrombocytopenia, heparin-induced skin lesions, and arterial thrombosis. Thromb. Haemost. 77(Suppl.):562 (Abstr.)
    • (1997) Thromb. Haemost. , vol.77 , Issue.SUPPL. , pp. 562
    • Warkentin, T.E.1
  • 38
    • 0031057075 scopus 로고    scopus 로고
    • Pseudopulmonary embolism: Acute respiratory distress in the syndrome of heparin-induced thrombocytopenia
    • 38. Popov D, Zarrabi H, Foda H, et al. 1997. Pseudopulmonary embolism: acute respiratory distress in the syndrome of heparin-induced thrombocytopenia. Am. J. Kidney Dis. 29:449-52
    • (1997) Am. J. Kidney Dis. , vol.29 , pp. 449-452
    • Popov, D.1    Zarrabi, H.2    Foda, H.3
  • 39
    • 0022640930 scopus 로고
    • A diagnostic test for heparin-induced thrombocytopenia
    • 39. Sheridan D, Carter C, Kelton JG. 1986. A diagnostic test for heparin-induced thrombocytopenia. Blood 67:27-30
    • (1986) Blood , vol.67 , pp. 27-30
    • Sheridan, D.1    Carter, C.2    Kelton, J.G.3
  • 40
    • 0026646478 scopus 로고
    • Determinants of donor platelet variability when testing for heparin-induced thrombocytopenia
    • 40. Warkentin TE, Hayward CPM, Smith CA, et al. 1992. Determinants of donor platelet variability when testing for heparin-induced thrombocytopenia. J. Lab. Clin. Med. 120:371-79
    • (1992) J. Lab. Clin. Med. , vol.120 , pp. 371-379
    • Warkentin, T.E.1    Hayward, C.P.M.2    Smith, C.A.3
  • 41
    • 0027169166 scopus 로고
    • Heparin-associated thrombocytopenia: Immune complexes are attached to the platelet membrane by the negative charge of highly sulphated oligosaccharides
    • 41. Greinacher A, Michels I, Liebenhoff U, et al. 1993. Heparin-associated thrombocytopenia: immune complexes are attached to the platelet membrane by the negative charge of highly sulphated oligosaccharides. Br. J. Haematol 84:711-16
    • (1993) Br. J. Haematol , vol.84 , pp. 711-716
    • Greinacher, A.1    Michels, I.2    Liebenhoff, U.3
  • 42
    • 0028335456 scopus 로고
    • Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzymelinked immunosorbent assay
    • 42. Greinacher A, Amiral J, Dummel V, et al. 1994. Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzymelinked immunosorbent assay. Transfusion 34:381-85
    • (1994) Transfusion , vol.34 , pp. 381-385
    • Greinacher, A.1    Amiral, J.2    Dummel, V.3
  • 43
    • 0027413887 scopus 로고
    • The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia
    • 43. Chong BH, Burgess J, Ismail F. 1993. The clinical usefulness of the platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia. Thromb. Haemost. 69:344-50
    • (1993) Thromb. Haemost. , vol.69 , pp. 344-350
    • Chong, B.H.1    Burgess, J.2    Ismail, F.3
  • 44
    • 0025951938 scopus 로고
    • A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia
    • 44. Greinacher A, Michels I, Kiefel V, et al. 1991. A rapid and sensitive test for diagnosing heparin-associated thrombocytopenia. Thromb. Haemost. 66:734-36
    • (1991) Thromb. Haemost. , vol.66 , pp. 734-736
    • Greinacher, A.1    Michels, I.2    Kiefel, V.3
  • 45
    • 0030463618 scopus 로고    scopus 로고
    • A diagnostic test for heparin-induced thrombocytopenia: Detection of platelet microparticles using flow cytometry
    • 45. Lee DH, Warkentin TE, Denomme GA, et al. 1996. A diagnostic test for heparin-induced thrombocytopenia: detection of platelet microparticles using flow cytometry. Br. J. Haematol. 95:724-31
    • (1996) Br. J. Haematol. , vol.95 , pp. 724-731
    • Lee, D.H.1    Warkentin, T.E.2    Denomme, G.A.3
  • 46
    • 0030964597 scopus 로고    scopus 로고
    • A sensitive and specific functional flow cytometric assay for the diagnosis of heparin-induced thrombocytopenia
    • 46. Tomer A. 1997. A sensitive and specific functional flow cytometric assay for the diagnosis of heparin-induced thrombocytopenia. Br. J. Haematol. 98:648-56
    • (1997) Br. J. Haematol. , vol.98 , pp. 648-656
    • Tomer, A.1
  • 47
    • 0031850163 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross-reactivity with low molecular weight heparin and heparinoid
    • 47. Newman PM, Swanson RL, Chong BH. 1998. Heparin-induced thrombocytopenia: IgG binding to PF4-heparin complexes in the fluid phase and cross-reactivity with low molecular weight heparin and heparinoid. Thromb. Haemost. 80: 292-97
    • (1998) Thromb. Haemost. , vol.80 , pp. 292-297
    • Newman, P.M.1    Swanson, R.L.2    Chong, B.H.3
  • 48
    • 0000149291 scopus 로고    scopus 로고
    • Low molecular weight heparinoid and heparin-induced thrombocytopenia
    • Abstr.
    • 48. Chong BH. 1996. Low molecular weight heparinoid and heparin-induced thrombocytopenia. Aust. NZ J. Med. 26:331 (Abstr.)
    • (1996) Aust. NZ J. Med. , vol.26 , pp. 331
    • Chong, B.H.1
  • 49
    • 0030888763 scopus 로고    scopus 로고
    • Orgaran (danaparoid sodium) use in the syndrome of heparin-induced thrombocytopenia
    • 49. Magnani HN. 1997. Orgaran (danaparoid sodium) use in the syndrome of heparin-induced thrombocytopenia. Platelets 8: 74-81
    • (1997) Platelets , vol.8 , pp. 74-81
    • Magnani, H.N.1
  • 50
    • 0000503379 scopus 로고    scopus 로고
    • Danaparoid (Orgaran for the treatment of heparin-induced thrombocytopenia (HIT and thrombosis: Effects on in vivo thrombin and cross-linked fibrin generation, and evaluation of the clinical significance of in vitro cross-reactivity (XR) of danaparoid for HIT-IgG
    • Abstr.
    • 50. Warkentin TE. 1996. Danaparoid (Orgaran ) for the treatment of heparin-induced thrombocytopenia (HIT) and thrombosis: effects on in vivo thrombin and cross-linked fibrin generation, and evaluation of the clinical significance of in vitro cross-reactivity (XR) of danaparoid for HIT-IgG. Blood 88(Suppl. 1): 626a (Abstr.)
    • (1996) Blood , vol.88 , Issue.SUPPL. 1
    • Warkentin, T.E.1
  • 51
    • 0026693798 scopus 로고
    • Hirudin: The promising antithrombotic
    • 51. Markwardt F. 1992. Hirudin: the promising antithrombotic. Cardiovasc. Drug Rev. 10:211-32
    • (1992) Cardiovasc. Drug Rev. , vol.10 , pp. 211-232
    • Markwardt, F.1
  • 52
    • 0000663136 scopus 로고    scopus 로고
    • Recombinant hirudin in the treatment of patients with heparin-induced thrombocytopenia (HIT)
    • Abstr.
    • 52. Greinacher A, Völpel H, Pötzsch B. 1996. Recombinant hirudin in the treatment of patients with heparin-induced thrombocytopenia (HIT). Blood 88(Suppl. 1): 281a (Abstr.)
    • (1996) Blood , vol.88 , Issue.SUPPL. 1
    • Greinacher, A.1    Völpel, H.2    Pötzsch, B.3
  • 53
    • 0002268239 scopus 로고    scopus 로고
    • Antihirudin antibodies induced by recombinant hirudin in the treatment of patients with heparin-induced thrombocytopenia (HIT)
    • Abstr.
    • 53. Eichler P, Greinacher A. 1996. Antihirudin antibodies induced by recombinant hirudin in the treatment of patients with heparin-induced thrombocytopenia (HIT). Ann. Hematol. 72(Suppl.):A4 (Abstr.)
    • (1996) Ann. Hematol. , vol.72 , Issue.SUPPL.
    • Eichler, P.1    Greinacher, A.2
  • 54
    • 0030611555 scopus 로고    scopus 로고
    • Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome
    • 54. Lewis BE, Walenga JM, Wallis DE. 1997. Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome. Semin. Thromb. Hemost. 23: 197-202
    • (1997) Semin. Thromb. Hemost. , vol.23 , pp. 197-202
    • Lewis, B.E.1    Walenga, J.M.2    Wallis, D.E.3
  • 55
    • 0029859093 scopus 로고    scopus 로고
    • Intraoperative urokinase as an alternative to heparin for patients with suspected heparin-induced thrombocytopenia requiring arterial reconstruction: Report of a case and review of the literature
    • 55. Weinmann EE, Carpenter JP. 1996. Intraoperative urokinase as an alternative to heparin for patients with suspected heparin-induced thrombocytopenia requiring arterial reconstruction: report of a case and review of the literature. J. Cardiovasc. Surg. 37:463-65
    • (1996) J. Cardiovasc. Surg. , vol.37 , pp. 463-465
    • Weinmann, E.E.1    Carpenter, J.P.2
  • 56
    • 0025301187 scopus 로고
    • Intraoperative management of patients with heparin-induced thrombocytopenia
    • 56. Kappa JR, Fisher CA, Todd B, et al. 1990. Intraoperative management of patients with heparin-induced thrombocytopenia. Ann. Thorac. Surg. 49:714-23
    • (1990) Ann. Thorac. Surg. , vol.49 , pp. 714-723
    • Kappa, J.R.1    Fisher, C.A.2    Todd, B.3
  • 57
    • 0031963059 scopus 로고    scopus 로고
    • Adenosine diphosphate (ADP) and ADP receptor play a major role in platelet activation/aggregation induced by serum from heparin-induced thrombocytopenia patients
    • 57. Polgár J, Eichler P, Greinacher A, et al. 1998. Adenosine diphosphate (ADP) and ADP receptor play a major role in platelet activation/aggregation induced by serum from heparin-induced thrombocytopenia patients. Blood 91:549-54
    • (1998) Blood , vol.91 , pp. 549-554
    • Polgár, J.1    Eichler, P.2    Greinacher, A.3
  • 58
    • 0026009696 scopus 로고
    • Rapid anticoagulation using ancrod for heparin-induced thrombocytopenia
    • 58. Demers C, Ginsberg JS, Brill-Edwards P, et al. 1991. Rapid anticoagulation using ancrod for heparin-induced thrombocytopenia. Blood 78: 2194-97
    • (1991) Blood , vol.78 , pp. 2194-2197
    • Demers, C.1    Ginsberg, J.S.2    Brill-Edwards, P.3
  • 59
    • 0030722915 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Pathogenesis, frequency, avoidance, and management
    • 59. Warkentin TE. 1997. Heparin-induced thrombocytopenia: pathogenesis, frequency, avoidance, and management. Drug Saf. 17:325-41
    • (1997) Drug Saf. , vol.17 , pp. 325-341
    • Warkentin, T.E.1


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