Cytolethal distending toxin: A bacterial toxin which disrupts the eukaryotic cell cycle

Chemical Research in Toxicology

Volumn 13, Issue 10, 2000, Pages 936-939

  Young, V B ^a,b   Schauer, D B ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; CYTOTOXIC AGENT;

ACTINOBACILLUS; ALPHA CHAIN; CAMPYLOBACTER JEJUNI; CELL CYCLE; CONFERENCE PAPER; CYTOTOXICITY; ENZYME ACTIVITY; ESCHERICHIA COLI; EUKARYOTE; HAEMOPHILUS DUCREYI; MICROTUBULE; SHIGELLA DYSENTERIAE; VIRULENCE;

ANIMALS; BACTERIAL TOXINS; CELL CYCLE; EUKARYOTIC CELLS; HUMANS;

EID: 0033787559     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx000091d     Document Type: Conference Paper

References (28)

1. Bacterial toxins: Friends or foes?
2. Enteric bacterial toxins: Mechanisms of action and linkage to intestinal secretion
3. A new heat-labile cytolethal distending toxin (CDLT) produced by Campylobacter spp
4. A new heat-labile cytolethal distending toxin (CDTL) produced by Escherichia coli isolates from clinical material
5. Cytolethal distending toxin sequence and activity in the enterohepatic pathogen Helicobacter hepaticus
6. The cytolethal distending toxin from the chancroid bacterium Haemophilus ducreyi induces cell-cycle arrest in the G2 phase
7. Effect of cytolethal distending toxin on F-actin assembly and cell division in Chinese hamster ovary cells
8. Campylobacter jejuni cytolethal distending toxin causes a G2-phase cell cycle block
9. Cytolethal distending toxin of Haemophilus ducreyi induces apoptotic death of Jurkat T cells
10. A new cytolethal distending toxin (CDT) from Escherichia coli producing CNF2 blocks HeLa cell division in G2/M phase
11. Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells
12. Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation
13. Cyclins and cell cycle checkpoints
14. The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks
15. A diffusible cytotoxin of Haemophilus ducreyi
16. Prevalence of cytolethal distending toxin production in Campylobacter jejuni and relatedness of Campylo-bacter sp. CdtB gene
17. Cloning, sequencing, and expression of the Escherichia coli cytolethal distending toxin genes
18. Cloning and sequencing of the genes encoding Escherichia coli cytolethal distending toxin
19. The cell cycle-specific growth-inhibitory factor produced by Actinobacillus actinomycetemcomitans is a cytolethal distending toxin
20. Identification of a cytolethal distending toxin gene locus and features of a virulence-associated region in Actinobacillus actinomycetemcomitans
21. Purification and identification of Haemophilus ducreyi cytotoxin by use of a neutralizing monoclonal antibody
22. Controlled study of cytolethal distending toxin-producing Escherichia coli infections in Bangladeshi children
23. Characterization of Escherichia coli strains from cases of childhood diarrhea in provincial southwestern Nigeria
24. Cytolethal distending toxin (CLDT) production by enteropathogenic Escherichia coli (EPEC)
25. Examination of diarrheagenicity of cytolethal distending toxins: Suckling mouse response to the products of the cdtABC genes of Shigella dysenteriae
26. Characterization of a Haemophilus ducreyi mutant deficient in expression of cytolethal distending toxin
27. Molecular interaction map of the mammalian cell cycle control and DNA repair systems
28. DNase I homologous residues in CtdB are critical for cytolethal distending toxin-mediated cell cycle arrest