Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 4, 2001, Pages 1162-1167

  Bantia, S ^a   Parker, C D ^a   Ananth, S L ^a   Horn, L L ^a   Andries, K ^a   Chand, P ^a   Kotian, P L ^a   Dehghani, A ^a   El Kattan, Y ^a   Lin, T ^a   Hutchison, T L ^a   Montgomery, J A ^a   Kellog, D L ^a   Babu, Y S ^a  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OSELTAMIVIR; PERAMIVIR; SIALIDASE; VIRUS ENZYME; ZANAMIVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE CALCULATION; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; FEMALE; INFLUENZA; INFLUENZA VIRUS; LETHALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; WEIGHT REDUCTION;

ACETAMIDES; ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; ANIMALS; ANTIVIRAL AGENTS; CYCLOPENTANES; ENZYME INHIBITORS; FEMALE; GUANIDINES; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED BALB C; NEURAMINIDASE; ORTHOMYXOVIRIDAE; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; PYRANS; SIALIC ACIDS; SPECIES SPECIFICITY; SURVIVAL ANALYSIS; TIME FACTORS; ZANAMIVIR;

EID: 0035080983     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.4.1162-1167.2001     Document Type: Article

References (15)

1. BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design
2. Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza
3. Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza
4. Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: Randomized controlled trials for prevention and treatment
5. Infection-permissive immunization with influenza virus neuraminidase prevents weight loss in infected mice
6. Oral administration of a prodrug of the influenza virus neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection
7. Purification and characterization of cytosolic sialidase from rat liver
8. Zanamivir in the prevention of influenza among healthy adults: A randomized controlled trial
9. Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-D-N-acetylneuraminate) substrate
10. GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets
11. Inhibition of influenza virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor
12. In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RWJ-270201
13. Cyctopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities
14. Dihydropyrancarboxamides related to zanamivir: A new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B
15. Rational design of potent sialidase-based inhibitors of influenza virus replication