The role of protein kinase C in regulating equine eosinophil adherence and superoxide production

Inflammation Research

Volumn 54, Issue 3, 2005, Pages 97-105

  Sepulveda, M F ^a   Greenaway, E C ^a   Avella, M ^a   Goode, N T ^a   Cunningham, F M ^a  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Adherence; Equine eosinophil; Protein kinase C; Superoxide

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; ADENOSINE TRIPHOSPHATE; ANTHELMINTIC AGENT; CYTOCHROME C; HISTAMINE; INTERLEUKIN 5; PHOSPHORUS 32; PLASTIC; PROTEIN KINASE C; PROTEIN KINASE C DELTA; PROTEIN KINASE C INHIBITOR; ROTTLERIN; STAUROSPORINE; SUPEROXIDE; TETANUS TOXOID; ZYMOSAN; CARBAZOLE DERIVATIVE; ENZYME INHIBITOR; EOSINOPHIL PEROXIDASE; INDOLE DERIVATIVE; RO 31-8220;

ANALYSIS OF VARIANCE; ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; EOSINOPHIL; FEMALE; HORSE; NONHUMAN; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SERUM; ANIMAL; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; ENZYMOLOGY; IC 50; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE;

ANALYSIS OF VARIANCE; ANIMALS; CARBAZOLES; CELL ADHESION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EOSINOPHIL PEROXIDASE; EOSINOPHILS; HISTAMINE; HORSES; INDOLES; INHIBITORY CONCENTRATION 50; INTERLEUKIN-5; PLASTICS; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; RNA INTERFERENCE; SUPEROXIDES; ZYMOSAN;

EID: 21344469437     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-004-1329-2     Document Type: Article

References (36)

1. Foster AP, Cunningham FM. The pathogenesis and immunopharmacology of equine insect hypersensitivity. Adv Vet Dermatol 1998; 3: 177-89.
2. Gleich GJ. Mechanisms of eosinophil associated inflammation. J Allergy Clin Immunol 2000; 105: 651-3.
3. Foster AP, Lees P, Cunningham FM. Actions of PAF receptor antagonists in ponies with the allergic skin disease, sweet itch. Inflammation Res 1995; 44: 412-17.
4. Foster AP, Cunningham FM. Histamine-induced adherence and migration of equine eosinophils. Am J Vet Res 1998; 59: 1153-9.
5. Foster AP, McKelvie JM, Cunningham FM. Inhibition of antigen-induced cutaneous responses of ponies with insect hypersensitivity by the histamine-1 receptor antagonist, chlorpheniramine. Vet Record 1998; 143: 189-93.
6. Bailey SR, Cunningham FM. Adherence of eosinophils from allergic and normal ponies to cultured equine endothelial cells. Inflammation Res 2001; 50: 32-8.
7. Benarafa C, Collins ME, Hamblin AS, Cunningham FM. A role for the chemokine eotaxin in the pathogenesis of equine sweet itch. Vet Record 2002; 151: 691-3.
8. Cunningham FM, Vandergrifft E, Bailey SR, Sepulveda MF, Goode NT, Horohov DW. Cloning, expression and biological activity of equine interleukin (IL)-5. Vet Immunol Immunopathol 2003; 95: 63-72.
9. Foster AP, Cunningham FM. Substance P induces activation, adherence and migration of equine eosinophils. J Vet Pharmacol Ther 2003; 26: 131-8.
10. Dekker LV, Parker PJ. Protein kinase C - a question of specificity. Trends Biochem Sci 1994; 19: 73-7.
11. Greenaway EC, Cunningham FM, Goode NT. Differential localisation of protein kinase C isotypes in equine eosinophils and neutrophils. J Leukoc Biol 2000; 68: 575-82.
12. Greenaway EC, Sepulveda MF, Cunningham FM, Goode NT. Protein kinase C (PKC) isotype profile in eosinophils from ponies with sweet itch and role in histamine-induced eosinophil activation. Vet Immunol Immunopathol 2003; 96: 53-63.
13. 2+, protein kinase C and phospholipases C and D. Biochem J 1995; 310: 795-806.
14. Dent G, Muňoz NM, Rühlmann E, Zhu X, Leff AR, Magnussen H et al. Protein kinase C inhibition enhances platelet-activating factor-induced eicosanoid production in human eosinophils. Am Rev Respir Cell Mol Biol 1998; 18: 136-44.
15. Egesten A, Malm J. Eosinophil leukocyte degranulation in response to serum-treated opsonized beads: C5a and platelet-activating factor enhance ECP release, with roles for protein kinases A and C. Allergy 1998; 53: 1066-73.
16. Lynch OT, Giembycz MA, Barnes PJ, Hellewell PG, Lindsay MA. 'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils. Br J Pharmacol 1999; 128: 1149-58.
17. 4-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils. Br J Pharmacol 2001; 134:797-806.
18. Bankers-Fulbright JL, Kita H, Gleich GJ. O'Grady SM. Regulation of human eosinophil NADPH oxidase activity: A central role for PKCδ. J Cell Physiol 2001; 189: 306-15.
19. Woschnagg C, Garcia RC, Venge P. The mechanisms of serum-treated zymosan (STZ)-induced oxidative metabolism by human eosinophils and the effects of IL-5 priming. Allergy 2001; 56: 639-45.
20. Takizawa T, Kato M, Kimura H, Suzuki M, Tachibana A, Obinata H et al. Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor. J Allergy Clin Immunol 2002; 110: 241-8.
21. 2+ and protein kinase C via distinct mechanisms. EMBO J. 1998; 17: 4340-5.
22. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H et al. Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö6976. J Biol Chem 1993; 268: 9194-47.
23. Wilkinson SE, Parker PJ, Nixon JS. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J 1993; 294: 335-7.
24. Gschwendt M, Müller HJ, Kielbassa K, Zang R, Kittstein W, Rincke G et al. A novel protein kinase inhibitor. Biochem Biophys Res Commun 1994; 199: 93-8.
25. Foster AP, Cunningham FM. Differential superoxide anion generation by equine eosinophils and neutrophils. Vet Immunol Immunopathol 1997; 59: 225-7.
26. Foster AP, McCabe PJ, Sanjar S, Cunningham FM. Agonist-induced adherence of equine eosinophils to fibronectin. Vet Immunol Immunopathol 1997; 56: 205-20.
27. Megson AC, Walker EM, Hill SJ. Role of protein kinase C alpha in signalling from the histamine H(1) receptor to the nucleus. Mol Pharmacol 2001; 59: 1012-21.
28. Koenderman L, Coffer P. Intracellular signaling and regulation of allergic reactions. Controlling allergic inflammation by signaling regulation of eosinophils. Allergy 2001; 56: 204-14.
29. Savkovic SD, Koutsouris A, Hecht G. PKC{zeta] participates in activation of inflammatory response induced by enteropathogenic E. coli. Am J Physiol Cell Physiol 2003; 285: C512-21.
30. Davis PD, Elliott LH, Harris W, Hill CH, Hurst SA, Keech E et al. Inhibitors of protein kinase C. 2. Substituted bisindolylmaleimides with improved potency and selectivity. J Med Chem 1992; 35: 994-1001.
31. Keller HU, Niggli V. The protein kinase C inhibitor Ro31-8220 selectively suppresses PMA- and diacylglycerol-induced fluid pinocytosis and actin polymerisation in PMNs. Biochem Biophys Res Commun 1993; 194: 1111-6.
32. Koenderman L, Van der Bruggen T, Schweizer RC, Warringa RAJ, Coffer P, Caldenhoven E et al. Eosinophil priming by cytokines: from cellular signal to in vivo modulation. Eur Respir J 1996; 9 suppl. 22: 119s-25s.
33. Crosby D, Poole AW. Physical and functional interaction between protein kinase C δ and Fyn tyrosine kinase in human platelets. J Biol Chem 2003; 278: 24533-41.
34. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000; 351: 95-105.
35. Bates ME, Bertics PJ, Calhoun WJ, Busse WW. Increased protein kinase C activity in low density eosinophils. J Immunol 1993; 150: 4486-93.
36. Goode NT, Hajibagheri MAN, Parker PJ. Protein kinase C (PKC)-induced PKC down-regulation: association with up-regulation of vesicle traffic. J Biol Chem 1995; 270: 2669-73.