PEGylation of yeast cytosine deaminase for pretargeting

Journal of Pharmaceutical Sciences

Volumn 94, Issue 6, 2005, Pages 1249-1258

  Xiong, May P ^a   Kwon, Glen S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cytosine deaminase; Dimer; Enzyme activity; PEGylation; Stability

Indexed keywords

CYTOSINE; CYTOSINE DEAMINASE; FLUCYTOSINE; MACROGOL;

AMINO TERMINAL SEQUENCE; ARTICLE; CONJUGATION; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME STABILITY; GEL PERMEATION CHROMATOGRAPHY; ISOMER; MOLECULAR CLONING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; YEAST;

EID: 21344468592     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20354     Document Type: Article

References (25)

1. McDonald DM, Baluk P. 2002. Significance of blood vessel leakiness in cancer. Cancer Res 62:5381-5385.
2. Maeda H. 1991. SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy. Adv Drug Deliv Rev 6:181-202.
3. Sharma SK, Bagshawe KD, Burke PJ, Boden JA, Rogers GT, Springer RG, Melton RF, Sherwood RF. 1994. Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy. Cancer 73:1114-1120.
4. Sharma SK. 1996. Accelerated clearance systems. Adv Drug Deliv Rev 22:315-324.
5. Knauf M, Bell DP, Hirtzer P, Luo Z-P, Young JD, Katre NV. 1988. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers. J Biol Chem 263:15064-15070.
6. Delgado C, Francis GF, Fisher D. 1992. The uses and properties of PEG-linked proteins. Crit Rev Ther Drug Carrier Syst 9:249-304.
7. Harris J, Zalipsky S. 1997. Polyethelyne(glycol): Chemistry and Biological Applications. American Chemical Society, Washington DC, 680:487.
8. Kodera Y, Matsushima A, Hiroto M, Nishimura H, Ishii A, Ueno T, Inada Y. 1998. PEGylation of proteins and bioactive substances for medical and technical applications. Prog Polym Sci 23:1233-1271.
9. Chapman A, Antoniw M, Spitali S, West S, Stephans S, King DJ. 1999. Therapeutic antibody fragments with prolonged in vivo half-lives. Nat Biotechnol 17:780-783.
10. Fung W, Porter JE, Bailon P. 1997. Strategies for the preparation and characterization of polyethylene glycol (PEG), Conjugated Pharmaceutical Protein. Polymer Preprints 38:565-566.
11. Senter PD, Springer CJ. 2001. Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates. Adv Drug Deliv Rev 53:247-264.
12. Niculescu-Duvaz I, Springer CJ. 1997. Antibody-directed enzyme prodrug therapy (ADEPT): A review. Adv Drug Deliv Rev 26:151-172.
13. Hamstra D, Rice DJ, Fahmy S, Ross BD, Rehemtulla A. 1999. Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase. Hum Gene Ther 10:1993-2003.
14. Kievit E, Nyati M, Ng E, Stegman LD, Parsels J, Ross BD, Rehemtulla A, Lawrence TS. 2000. Yeast cytosine deaminase improves radiosensitization and bystander effects by 5-fluorocytosine of human colorectal cancer xenografts. Cancer Res 60:6649-6655.
15. Huber B, Austin EA, Good SS, Knick VC, Tibbels S, Richards CA. 1993. In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res 53:4613-4626.
16. Kievit E, Bershad E, Ng E, Sethna P, Dev I, Lawrence TS, Rehemtulla A. 1999. Superiority of yeast cytosine over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts. Cancer Res 59:1417-1421.
17. Katsuragi T, Sonoda T, Matsumoto K, Sakai T, Tonomura K. 1988. Purification and some properties of cytosine deaminase from baker's yeast. Agric Biol Chem 53:1313-1319.
18. Ko T-P, Lin J-J, Hu C-Y, Hsu Y-H, Wang A H-J, Liaw S-H. 2003. Crystal structure of yeast cytosine deaminase. J Biol Chem 278:19111-19117.
19. Senter P, Su PCD, Katsuragi T, Sakai T, Cosand WL, Hellstrom I, Hellstrom KE. 1991. Generation of 5-fluorouracil from 5-fluorocytosine by monoclonal antiboty-cytosine deaminase conjugates. Bioconj Chem 2:447-451.
20. Voet D, Voet JG. 2004. Biochemistry, 3rd edition. Hoboken, NJ: John Wiley & Sons, Inc.
21. Ireton G, Black ME, Stoddard BL. 2003. The 1.14A crystal structure of yeast cytosine deaminase. Structure 11:961-972.
22. Beavis R, Chait BT, Standing KG, Ens W. 1990. Methods and mechanisms for producing ions from large molecules. NATO ASI, Series B Physics. 269p.
23. Katsuragi T, Shibata M, Sakai T, Tonomura K. 1988. Stabilization of cytosine deaminase from baker's yeast by immobilization. Agric Biol Chem 53:1515-1523.
24. Thornton J. 1981. Bisulphide bridges in globular proteins. J Molec Biol 151:261-287.
25. Matsumura M, Signor G, Matthews BW. 1989. Substantial increase of a protein stability by multiple disulphide bond. Nature 342:291-293.