메뉴 건너뛰기




Volumn 22, Issue 3, 1996, Pages 315-324

Accelerated clearance systems

Author keywords

ADEPT; antibody enzyme conjugates; clearance; inactivation

Indexed keywords

ANTIBODY DIRECTED ENZYME PRODRUG THERAPY; ANTIBODY ENZYME CONJUGATES; AVIDIN; BIOTIN; CLEARANCE; PLASMA ENZYME ACTIVITY; TUMOUR;

EID: 0030589713     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00441-3     Document Type: Review
Times cited : (7)

References (60)
  • 1
    • 0023619243 scopus 로고
    • Antibody directed enzymes revive anticancer prodrugs concept
    • [1] Bagshawe, K.D. (1987) Antibody directed enzymes revive anticancer prodrugs concept. Br. J. Cancer 56, 531-532.
    • (1987) Br. J. Cancer , vol.56 , pp. 531-532
    • Bagshawe, K.D.1
  • 3
    • 0025330441 scopus 로고
    • Iodine 131-labelled MAb F(ab′)2 fragments are more efficient and less toxic than intact CEA antibodies in radioimmunotherapy of large human colon carcinoma xenografted in nude mice
    • [3] Buchegger, F., Pelegrin. A., Delaloye, B. et al. (1990) Iodine 131-labelled MAb F(ab′)2 fragments are more efficient and less toxic than intact CEA antibodies in radioimmunotherapy of large human colon carcinoma xenografted in nude mice. J. Nucl. Med. 31, 1035-1044.
    • (1990) J. Nucl. Med. , vol.31 , pp. 1035-1044
    • Buchegger, F.1    Pelegrin, A.2    Delaloye, B.3
  • 4
    • 0027245812 scopus 로고
    • Comparative radioimmunotherapy using intact or F(ab′)2 fragments of 131-I anti-CEA antibody in a colonic xenograft model
    • [4] Pedley, R.B., Boden. J.A., Boden, R., Dale, R. and Begent, R.H.J. (1993) Comparative radioimmunotherapy using intact or F(ab′)2 fragments of 131-I anti-CEA antibody in a colonic xenograft model. Br. J. Cancer 68, 69-73.
    • (1993) Br. J. Cancer , vol.68 , pp. 69-73
    • Pedley, R.B.1    Boden, J.A.2    Boden, R.3    Dale, R.4    Begent, R.H.J.5
  • 5
    • 0027220125 scopus 로고
    • Site-specific prodrug activation by antibody-β-lactamase conjugates: Regression and long-term growth inhibition of human colon carcinoma xenograft models
    • [5] Meyer, D.L., Jungheim, L.N., Law, K.L. et al. (1993) Site-specific prodrug activation by antibody-β-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models. Cancer Res, 53, 3956-3963.
    • (1993) Cancer Res , vol.53 , pp. 3956-3963
    • Meyer, D.L.1    Jungheim, L.N.2    Law, K.L.3
  • 6
    • 0028348376 scopus 로고
    • Tumour-selective prodrug activation by fusion protein-mediated catalysis
    • [6] Bosslet, K., Czech, J. and Hoffman, D. (1994) Tumour-selective prodrug activation by fusion protein-mediated catalysis. Cancer Res. 54, 2151-2159.
    • (1994) Cancer Res. , vol.54 , pp. 2151-2159
    • Bosslet, K.1    Czech, J.2    Hoffman, D.3
  • 7
    • 18544410822 scopus 로고    scopus 로고
    • In vitro and in vivo characterization of a recombinant carboxypeptidase g(2) anti-CEA SCFV fusion protein
    • [7] Michael, N.P., Chester, K.A., Melton, R.G. et al. (1996) In vitro and in vivo characterization of a recombinant carboxypeptidase g(2) anti-CEA SCFV fusion protein. Immunotechnology 2(1), 47-57.
    • (1996) Immunotechnology , vol.2 , Issue.1 , pp. 47-57
    • Michael, N.P.1    Chester, K.A.2    Melton, R.G.3
  • 8
    • 0028091566 scopus 로고
    • Improved tumour targeting with chemically cross-linked recombinant antibody fragments
    • [8] King, D.J., Turner, A., Farnsworth, A.P.H. et al. (1994) Improved tumour targeting with chemically cross-linked recombinant antibody fragments. Cancer Res. 54, 6176-6185.
    • (1994) Cancer Res. , vol.54 , pp. 6176-6185
    • King, D.J.1    Turner, A.2    Farnsworth, A.P.H.3
  • 9
    • 9444227576 scopus 로고    scopus 로고
    • Radioimmunotherapy of colorectal carcinoma xenografts in nude mice with yttrium-90 A33 IgG and Tri-Fab (TFM)
    • [9] Antoniw, P., Farnsworth, A.P.H., Turner, A. et al. (1996) Radioimmunotherapy of colorectal carcinoma xenografts in nude mice with yttrium-90 A33 IgG and Tri-Fab (TFM). Br. J. Cancer 74, 513-524.
    • (1996) Br. J. Cancer , vol.74 , pp. 513-524
    • Antoniw, P.1    Farnsworth, A.P.H.2    Turner, A.3
  • 10
    • 0030135704 scopus 로고    scopus 로고
    • Thiolations, TC-99M labellings, and animal in vivo biodistributions of divalent monoclonal-antibody fragments
    • [10] Govindan, S.V., Goldenberg, D.M., Grebenau, R.C., Hansen, H.J., Griffiths, G.L. (1996) Thiolations, TC-99M labellings, and animal in vivo biodistributions of divalent monoclonal-antibody fragments. Bioconjugate Chem. 7(3), 290-297.
    • (1996) Bioconjugate Chem. , vol.7 , Issue.3 , pp. 290-297
    • Govindan, S.V.1    Goldenberg, D.M.2    Grebenau, R.C.3    Hansen, H.J.4    Griffiths, G.L.5
  • 11
    • 0029890636 scopus 로고    scopus 로고
    • Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts
    • [11] Hu, S., Shively, L., Raubitschek, Sherman, M., Williams et al. (1996) Minibody: a novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts. Cancer Res. 56, 3055-3061.
    • (1996) Cancer Res. , vol.56 , pp. 3055-3061
    • Hu, S.1    Shively, L.2    Raubitschek3    Sherman, M.4    Williams5
  • 12
    • 0030020157 scopus 로고    scopus 로고
    • Preparation of a trivalent antigen-binding construct using polyoxime chemistry: Improved biodistribution and potential for therapeutic application
    • [12] Werten, R.C., Lankinen, M., Offord, R.E., Schubiger, P.A., Smith, A. and Rose, K. (1996) Preparation of a trivalent antigen-binding construct using polyoxime chemistry: improved biodistribution and potential for therapeutic application. Cancer Res. 56, 809-815.
    • (1996) Cancer Res. , vol.56 , pp. 809-815
    • Werten, R.C.1    Lankinen, M.2    Offord, R.E.3    Schubiger, P.A.4    Smith, A.5    Rose, K.6
  • 13
    • 0019960411 scopus 로고
    • Liposomally entrapped second antibody improves tumour imaging with radiolabelled (first) antitumour antibody
    • [13] Begent, R.H.J., Keep, P.A., Green, A.J. et al. (1982) Liposomally entrapped second antibody improves tumour imaging with radiolabelled (first) antitumour antibody. Lancet ii, 739.
    • (1982) Lancet , vol.2 , pp. 739
    • Begent, R.H.J.1    Keep, P.A.2    Green, A.J.3
  • 15
    • 0020663115 scopus 로고
    • Improved radioimmunodetection of tumours using second antibody
    • [15] Bradwell, A.R., Vaughan, A., Fairweather, D.S. and Dykes, P.W. (1983) Improved radioimmunodetection of tumours using second antibody. (Letter to the Editor). Lancet i, 247.
    • (1983) Lancet , vol.1 , pp. 247
    • Bradwell, A.R.1    Vaughan, A.2    Fairweather, D.S.3    Dykes, P.W.4
  • 17
    • 0021248962 scopus 로고
    • Second antibody clearance of radiolabelled antibody in cancer radioimmunodetection
    • [17] Sharkey, R.M., Primus, F.J. and Goldenberg, D.M. (1984) Second antibody clearance of radiolabelled antibody in cancer radioimmunodetection. Proc. Natl. Acad. Sci. (USA) 81, 2843.
    • (1984) Proc. Natl. Acad. Sci. (USA) , vol.81 , pp. 2843
    • Sharkey, R.M.1    Primus, F.J.2    Goldenberg, D.M.3
  • 18
    • 0023635232 scopus 로고
    • Anti-antibody enhancement of iodine-131-anti-CEA radioimmunodetection in experimental and clinical studies
    • [18] Goldenberg, D.M., Sharkey, R. and Ford, E. (1987) Anti-antibody enhancement of iodine-131-anti-CEA radioimmunodetection in experimental and clinical studies. J. Nucl. Med. 28(10), 1604-1610.
    • (1987) J. Nucl. Med. , vol.28 , Issue.10 , pp. 1604-1610
    • Goldenberg, D.M.1    Sharkey, R.2    Ford, E.3
  • 19
    • 0024398736 scopus 로고
    • Second antibody for improvement of antibody imaging: Liposome-entrapped and free preparations in animal and human studies
    • [19] Begent, R.H.J., Chester, K.A., Bagshawe, K.D. et al. (1989) Second antibody for improvement of antibody imaging: liposome-entrapped and free preparations in animal and human studies. Clin. Exp. Immunol. 78, 307-313.
    • (1989) Clin. Exp. Immunol. , vol.78 , pp. 307-313
    • Begent, R.H.J.1    Chester, K.A.2    Bagshawe, K.D.3
  • 20
    • 0024557324 scopus 로고
    • The effect of second antibody clearance on the distribution and dosimetry of radiolabelled anti-CEA antibody in a human colonic tumour xenograft model
    • [20] Pedley, R.B., Dale, R., Boden, J.A., Begent, R.H.J., Keep, P.A. and Green, A.J. (1989) The effect of second antibody clearance on the distribution and dosimetry of radiolabelled anti-CEA antibody in a human colonic tumour xenograft model. Int. J. Cancer 43, 713-718.
    • (1989) Int. J. Cancer , vol.43 , pp. 713-718
    • Pedley, R.B.1    Dale, R.2    Boden, J.A.3    Begent, R.H.J.4    Keep, P.A.5    Green, A.J.6
  • 21
    • 0024416962 scopus 로고
    • Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for colorectal cancer
    • [21] Begent, R.H.J., Ledermann, J.A., Green, A.J., Bagshawe, K.D., Riggs, S.J. et al. (1989) Antibody distribution and dosimetry in patients receiving radiolabelled antibody therapy for colorectal cancer. Br. J. Cancer 60, 406-412.
    • (1989) Br. J. Cancer , vol.60 , pp. 406-412
    • Begent, R.H.J.1    Ledermann, J.A.2    Green, A.J.3    Bagshawe, K.D.4    Riggs, S.J.5
  • 22
    • 0028825421 scopus 로고
    • Use of anticytokeratin monoclonal anti-idiotypic antibodies to improve tumour: Non-tumour ratio in experimental radioimmunolocalisation
    • [22] Ullen, A., Sanderstrom, P., Ahlstrom, K.R., Sundstrom, B., Nilsson, B., Arlestig, L. and Stigbrand, T. (1995) Use of anticytokeratin monoclonal anti-idiotypic antibodies to improve tumour: non-tumour ratio in experimental radioimmunolocalisation. Cancer Res. (Suppl) 55, 5868s-5873s.
    • (1995) Cancer Res. (Suppl) , vol.55
    • Ullen, A.1    Sanderstrom, P.2    Ahlstrom, K.R.3    Sundstrom, B.4    Nilsson, B.5    Arlestig, L.6    Stigbrand, T.7
  • 23
    • 0024240288 scopus 로고
    • Blood clearance of radiolabelled antibody: Enhancement by lactosamination and treatment with biotin-avidin or antimouse IgG antibodies
    • [23] Klibanov, A.L., Martynov, A.V., Slinkin, M.A. et al. (1988) Blood clearance of radiolabelled antibody: enhancement by lactosamination and treatment with biotin-avidin or antimouse IgG antibodies. J. Nucl. Med. 29, 1951-1956.
    • (1988) J. Nucl. Med. , vol.29 , pp. 1951-1956
    • Klibanov, A.L.1    Martynov, A.V.2    Slinkin, M.A.3
  • 24
    • 0028145615 scopus 로고
    • Improved clearance of radiolabelled biotinylated monoclonal antibody following the infusion of avidin as a 'chase' without decreased accumulation in the target tumour
    • [24] Kobayashi, H., Sakahara, H., Hosono, M., Yao, Z.S., Toyama, S., Endo, K. and Konishi, J. (1994) Improved clearance of radiolabelled biotinylated monoclonal antibody following the infusion of avidin as a 'chase' without decreased accumulation in the target tumour. J. Nucl. Med. 35, 1677-1684.
    • (1994) J. Nucl. Med. , vol.35 , pp. 1677-1684
    • Kobayashi, H.1    Sakahara, H.2    Hosono, M.3    Yao, Z.S.4    Toyama, S.5    Endo, K.6    Konishi, J.7
  • 27
    • 0026581622 scopus 로고
    • Two-step tumour targeting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin
    • [27] Paganelli, G., Belloni, C., Magnani, P. et al. (1992) Two-step tumour targeting in ovarian cancer patients using biotinylated monoclonal antibodies and radioactive streptavidin. Eur. J. Nucl. Med. 19, 322-329.
    • (1992) Eur. J. Nucl. Med. , vol.19 , pp. 322-329
    • Paganelli, G.1    Belloni, C.2    Magnani, P.3
  • 28
    • 0028331146 scopus 로고
    • Clearance of circulating radio-antibodies using streptavidin or second antibodies in a xenograft model
    • [28] Marshall, D., Pediey, R.B., Boden, J.A., Boden, R. and Begent, R.H.J. (1994) Clearance of circulating radio-antibodies using streptavidin or second antibodies in a xenograft model. Br. J. Cancer 69, 502-507.
    • (1994) Br. J. Cancer , vol.69 , pp. 502-507
    • Marshall, D.1    Pediey, R.B.2    Boden, J.A.3    Boden, R.4    Begent, R.H.J.5
  • 29
    • 0028278863 scopus 로고
    • Streptavidin distribution in metastatic tumours pretargeted with a biotinylated monoclonal antibody: Theoretical and experimental pharmacokinetics
    • [29] Sung, C., Van Osdol, W.W., Saga, T., Neumann, R.D., Dedrick, R.L. and Weinstein, J.N. (1994) Streptavidin distribution in metastatic tumours pretargeted with a biotinylated monoclonal antibody: theoretical and experimental pharmacokinetics. Cancer Res. 54, 2166-2175.
    • (1994) Cancer Res. , vol.54 , pp. 2166-2175
    • Sung, C.1    Van Osdol, W.W.2    Saga, T.3    Neumann, R.D.4    Dedrick, R.L.5    Weinstein, J.N.6
  • 30
    • 0029921429 scopus 로고    scopus 로고
    • Antibody-dependent signal amplification in tumour xenografts after pretreatment with biotinylated monoclonal antibody and avidin or streptavidin
    • [30] Kassie, A.I., Jones, P.L., Matalka, K.Z. and Adelstein, S.J. (1996) Antibody-dependent signal amplification in tumour xenografts after pretreatment with biotinylated monoclonal antibody and avidin or streptavidin. J. Nucl. Med. 37, 343-352.
    • (1996) J. Nucl. Med. , vol.37 , pp. 343-352
    • Kassie, A.I.1    Jones, P.L.2    Matalka, K.Z.3    Adelstein, S.J.4
  • 31
    • 9444221932 scopus 로고    scopus 로고
    • Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin
    • [31] Otsuji, E., Yamaguchi, T., Matsumura, H. et al. (1996) Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin. Br. J. Cancer 74, 597-602.
    • (1996) Br. J. Cancer , vol.74 , pp. 597-602
    • Otsuji, E.1    Yamaguchi, T.2    Matsumura, H.3
  • 32
    • 0026356523 scopus 로고
    • Three-step monoclonal antibody tumour targeting in carcinoembryonic antigen positive patients
    • [32] Paganelli, G., Magnani, P., Zito, F. et al. (1991) Three-step monoclonal antibody tumour targeting in carcinoembryonic antigen positive patients. Cancer Res. 51, 5960-5966.
    • (1991) Cancer Res. , vol.51 , pp. 5960-5966
    • Paganelli, G.1    Magnani, P.2    Zito, F.3
  • 33
    • 0028221948 scopus 로고
    • Two-step targeting of experimental lung metastases with biotinylated antibody and radiolabelled streptavidin
    • [33] Saga, T., Weinstein, J.N., Jeong, J.M. et al. (1994) Two-step targeting of experimental lung metastases with biotinylated antibody and radiolabelled streptavidin. Cancer Res. 54, 2160-2165.
    • (1994) Cancer Res. , vol.54 , pp. 2160-2165
    • Saga, T.1    Weinstein, J.N.2    Jeong, J.M.3
  • 34
    • 0029035433 scopus 로고
    • Improved targeting of radiolabelled streptavidin in tumours pretargeted with biotinylated monoclonal antibodies through an avidin chase
    • [34] Yao, Z., Zhang, M., Kobayashi, H., Sakahara, H., Nakada, H., Yamashina, I. and Konishi, J. (1995) Improved targeting of radiolabelled streptavidin in tumours pretargeted with biotinylated monoclonal antibodies through an avidin chase. J. Nucl. Med. 36, 837-841.
    • (1995) J. Nucl. Med. , vol.36 , pp. 837-841
    • Yao, Z.1    Zhang, M.2    Kobayashi, H.3    Sakahara, H.4    Nakada, H.5    Yamashina, I.6    Konishi, J.7
  • 36
    • 0028891121 scopus 로고
    • Galactosylated streptavidin for improved clearance of biotinylated intact and F(ab′)2 fragments of an anti-tumour antibody
    • [36] Marshall, D., Pedley, R.B., Melton, R.G., Boden, J.A., Boden, R., and Begent, R.H.J. (1995) Galactosylated streptavidin for improved clearance of biotinylated intact and F(ab′)2 fragments of an anti-tumour antibody. Br. J. Cancer 71, 18-24.
    • (1995) Br. J. Cancer , vol.71 , pp. 18-24
    • Marshall, D.1    Pedley, R.B.2    Melton, R.G.3    Boden, J.A.4    Boden, R.5    Begent, R.H.J.6
  • 40
    • 0025373638 scopus 로고
    • Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model
    • [40] Sharma, S.K., Bagshawe, K.D., Burke, P.J., Boden, R.W. and Rogers, G.T. (1990) Inactivation and clearance of an anti-CEA carboxypeptidase G2 conjugate in blood after localisation in a xenograft model. Br. J. Cancer 61, 659-662.
    • (1990) Br. J. Cancer , vol.61 , pp. 659-662
    • Sharma, S.K.1    Bagshawe, K.D.2    Burke, P.J.3    Boden, R.W.4    Rogers, G.T.5
  • 41
    • 0023203173 scopus 로고
    • Biodistribution of antibodies after intraperitoneal or intravenous injection and effect of carbohydrate modifications
    • [41] Mattes, M.J. (1987) Biodistribution of antibodies after intraperitoneal or intravenous injection and effect of carbohydrate modifications. J. Natl. Cancer Inst. 79, 850-863.
    • (1987) J. Natl. Cancer Inst. , vol.79 , pp. 850-863
    • Mattes, M.J.1
  • 42
    • 0016322758 scopus 로고
    • The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins
    • [42] Ashwell, G. and Morell, A.G. (1974) The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins. Adv. Enzymol. 41, 99-128.
    • (1974) Adv. Enzymol. , vol.41 , pp. 99-128
    • Ashwell, G.1    Morell, A.G.2
  • 43
    • 0019309619 scopus 로고
    • Carbohydrate-mediated clearance of immune complexes from circulation. A role for galactose residues in the hepatic uptake of IgG-antigen complexes
    • [43] Thornberg, R.W., Day, J.F., Baynes, J.W. and Thorpe, S.R. (1980) Carbohydrate-mediated clearance of immune complexes from circulation. A role for galactose residues in the hepatic uptake of IgG-antigen complexes. J. Biol. Chem. 255, 6820-6825.
    • (1980) J. Biol. Chem. , vol.255 , pp. 6820-6825
    • Thornberg, R.W.1    Day, J.F.2    Baynes, J.W.3    Thorpe, S.R.4
  • 45
    • 0029993066 scopus 로고    scopus 로고
    • Altered biodistribution of an antibody-enzyme conjugate modified with polyethylene glycol
    • [45] Eno-Amooquaye, E.A., Searle, F., Boden, J.A., Sharma, S.K. and Burke, P.J. (1996) Altered biodistribution of an antibody-enzyme conjugate modified with polyethylene glycol. Br. J. Cancer 73, 1323-1327.
    • (1996) Br. J. Cancer , vol.73 , pp. 1323-1327
    • Eno-Amooquaye, E.A.1    Searle, F.2    Boden, J.A.3    Sharma, S.K.4    Burke, P.J.5
  • 46
    • 0029416920 scopus 로고
    • Plasma clearance of an antibody-enzyme conjugate in ADEPT by monoclonal anti-enzyme: Its effect on prodrug activation in vivo
    • [46] Rogers, G.T., Burke, P.J., Sharma, S.K., Koodie, R. and Boden, J.A. (1995) Plasma clearance of an antibody-enzyme conjugate in ADEPT by monoclonal anti-enzyme: its effect on prodrug activation in vivo. Br. J. Cancer 72, 1357-1363.
    • (1995) Br. J. Cancer , vol.72 , pp. 1357-1363
    • Rogers, G.T.1    Burke, P.J.2    Sharma, S.K.3    Koodie, R.4    Boden, J.A.5
  • 48
    • 0002726158 scopus 로고
    • Antibody directed enzyme prodrug therapy: A pilot-scale clinical trial
    • [48] Bagshawe, K.D., Sharma, S.K., Springer, C.J. and Antoniw, P. (1995) Antibody directed enzyme prodrug therapy: a pilot-scale clinical trial. Tumour Targeting 1, 17-29.
    • (1995) Tumour Targeting , vol.1 , pp. 17-29
    • Bagshawe, K.D.1    Sharma, S.K.2    Springer, C.J.3    Antoniw, P.4
  • 49
    • 0028014458 scopus 로고
    • Galactosylated antibodies and antibody-enzyme conjugates in antibody directed enzyme prodrug therapy
    • [49] Sharma, S.K., Bagshawe, K.D., Burke, P.J., Boden, J.A., Rogers, G.T. et al. (1994) Galactosylated antibodies and antibody-enzyme conjugates in antibody directed enzyme prodrug therapy. Cancer 73(3), 1114-1120.
    • (1994) Cancer , vol.73 , Issue.3 , pp. 1114-1120
    • Sharma, S.K.1    Bagshawe, K.D.2    Burke, P.J.3    Boden, J.A.4    Rogers, G.T.5
  • 52
    • 0027656118 scopus 로고
    • Application of monoclonal antibodies against cytosine deaminase for the in vivo clearance of cytosine deaminase immunoconjugate
    • [52] Kerr, D.E., Garrigues, U.S., Wallace, P.M., Hellstrom, K.E., Hellstrom, I. and Senter, P.D. (1993) Application of monoclonal antibodies against cytosine deaminase for the in vivo clearance of cytosine deaminase immunoconjugate. Biconjugate Chem. 4(5), 353-357.
    • (1993) Biconjugate Chem. , vol.4 , Issue.5 , pp. 353-357
    • Kerr, D.E.1    Garrigues, U.S.2    Wallace, P.M.3    Hellstrom, K.E.4    Hellstrom, I.5    Senter, P.D.6
  • 53
    • 0028335819 scopus 로고
    • Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine
    • [53] Wallace, P.M., MacMaster, J.F., Smith, V.F., Kerr, D.E., Senter, P.D. and Cosand, W.L. (1994) Intratumoral generation of 5-fluorouracil mediated by an antibody-cytosine deaminase conjugate in combination with 5-fluorocytosine. Cancer Res. 54, 2719-2723.
    • (1994) Cancer Res. , vol.54 , pp. 2719-2723
    • Wallace, P.M.1    MacMaster, J.F.2    Smith, V.F.3    Kerr, D.E.4    Senter, P.D.5    Cosand, W.L.6
  • 54
    • 0027280510 scopus 로고
    • Influence of syngeneic monoclonal anti-idiotypic antibodies to murine monoclonal antibodies against tumour-associated antigens on the biodistribution of their target antibodies and their fragments
    • [54] Pimm, M.V., Demignot, S. and Gribben, S.J. (1993) Influence of syngeneic monoclonal anti-idiotypic antibodies to murine monoclonal antibodies against tumour-associated antigens on the biodistribution of their target antibodies and their fragments. J. Cancer Res. Clin. Oncol. 119, 408-414.
    • (1993) J. Cancer Res. Clin. Oncol. , vol.119 , pp. 408-414
    • Pimm, M.V.1    Demignot, S.2    Gribben, S.J.3
  • 55
    • 0028054226 scopus 로고
    • The fate of antibodies and their radiolabels bound to tumour cells in vitro - The effect of cross-linking at the cell-surface and of anti-idiotype antibodies
    • [55] Ong, G.L., Marria, V. and Mattes M.J. (1994) The fate of antibodies and their radiolabels bound to tumour cells in vitro - the effect of cross-linking at the cell-surface and of anti-idiotype antibodies. Cancer Immunol. Immunother. 39, 325-331.
    • (1994) Cancer Immunol. Immunother. , vol.39 , pp. 325-331
    • Ong, G.L.1    Marria, V.2    Mattes, M.J.3
  • 56
    • 0029085586 scopus 로고
    • A monoclonal antibody against human β-glucuronidase for application in antibody-directed enzyme prodrug therapy
    • [56] Haisma, H.J., Van Muijen, M., Scheffer, G., Scheper, R.J., Pinedo, H.M. and Boven, E. (1995) A monoclonal antibody against human β-glucuronidase for application in antibody-directed enzyme prodrug therapy. Hybridoma 14(4), 377-382.
    • (1995) Hybridoma , vol.14 , Issue.4 , pp. 377-382
    • Haisma, H.J.1    Van Muijen, M.2    Scheffer, G.3    Scheper, R.J.4    Pinedo, H.M.5    Boven, E.6
  • 57
    • 0025955579 scopus 로고
    • Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds
    • [57] Springer, C.J., Bagshawe, K.D., Sharma, S.K., Searle, F., Boden, J.A. et al. (1991) Ablation of human choriocarcinoma xenografts in nude mice by antibody-directed enzyme prodrug therapy (ADEPT) with three novel compounds. Eur. J. Cancer 27, 1361-1366.
    • (1991) Eur. J. Cancer , vol.27 , pp. 1361-1366
    • Springer, C.J.1    Bagshawe, K.D.2    Sharma, S.K.3    Searle, F.4    Boden, J.A.5
  • 58
    • 0027538834 scopus 로고
    • Antitumour effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug
    • [58] Blakey, D.C., Valcaccia, B.E., East, S. et al. (1993) Antitumour effects of an antibody-carboxypeptidase G2 conjugate in combination with a benzoic acid mustard prodrug. Cell Biophys. 22, 1-8.
    • (1993) Cell Biophys. , vol.22 , pp. 1-8
    • Blakey, D.C.1    Valcaccia, B.E.2    East, S.3
  • 59
    • 0028694296 scopus 로고
    • Antibody directed enzyme prodrug therapy (ADEPT): A three-phase study in ovarian tumour xenografts
    • [59] Sharma, S.K., Boden, J.A., Springer, C.J., Burke, P.J. and Bagshawe, K.D. (1994) Antibody directed enzyme prodrug therapy (ADEPT): a three-phase study in ovarian tumour xenografts. Cell Biophys. 24, 219-228.
    • (1994) Cell Biophys. , vol.24 , pp. 219-228
    • Sharma, S.K.1    Boden, J.A.2    Springer, C.J.3    Burke, P.J.4    Bagshawe, K.D.5
  • 60
    • 8944233863 scopus 로고    scopus 로고
    • ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumour regressions in colorectal tumour xenografts
    • [60] Blakey, D.C., Burke, P.J., Davies, D.H. et al. (1996) ZD2767, an improved system for antibody-directed enzyme prodrug therapy that results in tumour regressions in colorectal tumour xenografts. Cancer Res. 56, 3287-3292.
    • (1996) Cancer Res. , vol.56 , pp. 3287-3292
    • Blakey, D.C.1    Burke, P.J.2    Davies, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.