Efficient decontamination of zearalenone, the mycotoxin of cereal pathogen, by transgenic yeasts through the expression of a synthetic lactonohydrolase gene

Applied Microbiology and Biotechnology

Volumn 67, Issue 6, 2005, Pages 838-844

  Takahashi Ando, Naoko ^a   Tokai, Takeshi ^a   Hamamoto, Hiroshi ^a   Yamaguchi, Isamu ^a   Kimura, Makoto ^a  

^a Elements Chemistry Laboratory   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DETOXIFICATION; ENZYMES; GENES; OPTIMIZATION; SYNTHESIS (CHEMICAL); YEAST;

ANTIOXIDANT COMPOUNDS; DETOXIFICATION GENE; ESTROGENIC MYCOTOXIN; ZEARALENONE (ZEN);

CROPS;

ALPHA ZEARALENOL; BETA REDUCTASE; BETA ZEARALENOL; HYDROLASE; LACTONOHYDROLASE; OXIDOREDUCTASE; UNCLASSIFIED DRUG; ZEARALENONE;

PATHOGEN;

ARTICLE; CODON; CONTROLLED STUDY; DETOXIFICATION; GENE EXPRESSION; GENE SYNTHESIS; INCUBATION TEMPERATURE; INCUBATION TIME; NONHUMAN; SACCHAROMYCES CEREVISIAE; TEMPERATURE SENSITIVITY; TRANSGENIC ORGANISM;

AMINO ACID SEQUENCE; BIODEGRADATION, ENVIRONMENTAL; DECONTAMINATION; MOLECULAR SEQUENCE DATA; PLASMIDS; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SEQUENCE ALIGNMENT; ZEARALENONE; ZERANOL;

DETOXICATION; ENZYMES; FARM CROPS; GENES; OPTIMIZATION; SACCHAROMYCES CEREVISIAE; SYNTHESIS; YEASTS;

BIONECTRIA OCHROLEUCA; FUSARIUM; SACCHAROMYCES CEREVISIAE;

EID: 21344464976     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-004-1816-y     Document Type: Article

References (28)

1. Bauer J, Heinritzi K, Gareis M, Gedek B (1987) Changes in the genital tract of female swine after feeding with practice-relevant amounts of zearalenone. Tierarztl Prax 15:33-36
2. Blanquet S, Marol-Bonnin S, Beyssac E, Pompon D, Renaud M, Alric M (2001) The 'biodrug' concept: an innovative approach to therapy. Trends Biotechnol 19:393-400
3. Blanquet S, Meunier JP, Minekus M, Marol-Bonnin S, Alric M (2003) Recombinant Saccharomyces cerevisiae expressing P450 in artificial digestive systems: a model for biodetoxication in the human digestive environment. Appl Environ Microbiol 69:2884-2892
4. Blanquet S, Antonelli R, Laforet L, Denis S, Marol-Bonnin S, Alric M (2004) Living recombinant Saccharomyces cerevisiae secreting proteins or peptides as a new drug delivery system in the gut. J Biotechnol 110:37-49
5. Böswald C, Engelhardt G, Vogel H, Wallnöfer PR (1995) Metabolism of the Fusarium mycotoxins zearalenone and deoxynivalenol by yeast strains of technological relevance. Nat Toxins 3:138-144
6. Bucchini L, Goldman LR (2002) Starlink corn: a risk analysis. Environ Health Perspect 110:5-13
7. Creppy EE (2002) Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol Lett 127:19-28
8. Dillon PJ, Rosen CA (1990) A rapid method for the construction of synthetic genes using the polymerase chain reaction. Biotechniques 9:298-300
9. Etienne M, Jemmali M (1982) Effects of zearalenone (F2) on estrous activity and reproduction in gilts. J Anim Sci 55:1-10, http:// www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= pubmed&dopt= Abstract&list_uids=6214538
10. Gregg K, Hamdorf B, Henderson K, Kopecny J, Wong C (1998) Genetically modified ruminal bacteria protect sheep from fluoroacetate poisoning. Appl Environ Microbiol 64:3496-3498
11. Kakeya H, Takahashi-Ando N, Kimura M, Onose R, Yamaguchi I, Osada H (2002) Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp. Biosci Biotechnol Biochem 66:2723-2726
12. Karlovsky P (1999) Biological detoxification of fungal toxins and its use in plant breeding, feed and food production. Nat Toxins 7:1-23
13. Kiessling KH, Pettersson H, Sandholm K, Olsen M (1984) Metabolism of aflatoxin, ochratoxin, zearalenone, and three trichothecenes by intact rumen fluid, rumen protozoa, and rumen bacteria. Appl Environ Microbiol 47:1070-1073
14. Kimura M, Kamakura T, Tao QZ, Kaneko I, Yamaguchi I (1994) Cloning of the blasticidin S deaminase gene (BSD) from Aspergillus terreus and its use as a selectable marker for Schizosaccharomyces pombe and Pyricularia oryzae. Mol Gen Genet 242:121-129
15. Lemke SL, Mayura K, Ottinger SE, McKenzie KS, Wang N, Fickey C, Kubena LF, Phillips TD (1999) Assessment of the estrogenic effects of zearalenone after treatment with ozone utilizing the mouse uterine weight bioassay. J Toxicol Environ Health A 56:283-295
16. Li FQ, Li YW, Luo XY, Yoshizawa T (2002) Fusarium toxins in wheat from an area in Henan Province, PR China, with a previous human red mould intoxication episode. Food Addit Contam 19:163-167, http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids= 11820498
17. Malarkey T (2003) Human health concerns with GM crops. Mutat Res 544:217-221
18. Mercenier A, Wiedermann U, Breiteneder H (2001) Edible genetically modified microorganisms and plants for improved health. Curr Opin Biotechnol 12:510-515
19. Pittet A (1998) Natural occurrence of mycotoxins in foods and feeds - an updated review. Rev Med Vet 149:479-492
20. Ryu D, Jackson LS, Bullerman LB (2002) Effects of processing on zearalenone. Adv Exp Med Biol 504:205-216
21. Schoental R (1983) Precocious sexual development in Puerto-Rico and estrogenic myco-toxins (zearalenone). Lancet 1:537
22. Scott PM, Trenholm HL, Sutton MD (1985) Mycotoxins: a Canadian perspective. National Research Council of Canada, Ottawa
23. Shier WT, Shier AC, Xie W, Mirocha CJ (2001) Structure-activity relationships for human estrogenic activity in zearalenone mycotoxins. Toxicon 39:1435-1438
24. Szuets P, Mesterhazy A, Falkay GY, Bartok T (1997) Early telearche symptoms in children and their relations to zearalenone contamination in foodstuffs. Cereal Res Commun 25:429-436
25. Takahashi-Ando N, Kimura M, Kakeya H, Osada H, Yamaguchi I (2002) A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning. Biochem J 365:1-6
26. Takahashi-Ando N, Ohsato S, Shibata T, Hamamoto H, Yamaguchi I, Kimura M (2004) Metabolism of zearalenone by genetically modified organisms expressing the detoxification gene from Clonostachys rosea. Appl Environ Microbiol 70:3239-3245
27. Wallace RJ (1994) Ruminal microbiology, biotechnology, and ruminant nutrition: progress and problems. J Anim Sci 72:2992-3003
28. Yuwai KE, Rao KS, Singh K, Tanaka T, Ueno Y (1994) Occurrence of nivalenol, deoxynivalenol, and zearalenone in imported cereals in Papua, New Guinea. Nat Toxins 2:19-21