The mouse immune response to human fibrinogen reveals an autoimmune component against mouse fibrinogen

Cellular Immunology

Volumn 233, Issue 1, 2005, Pages 41-52

  Rubin, Bent ^a,c   Matron, Catherine ^a,b  

^a CHU PURPAN   (France)

^b LAVAL UNIVERSITY   (Canada)

^c INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Arthritis; Autoimmunity; Coagulation; Immunological memory; Regulation; Tolerance

Indexed keywords

COLLAGEN TYPE 2; FIBRINOGEN; HUMAN SERUM ALBUMIN; MYELIN BASIC PROTEIN; OVALBUMIN; RHEUMATOID FACTOR; THYROGLOBULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; BLOOD CLOTTING TIME; CONTROLLED STUDY; CROSS REACTION; FEEDBACK SYSTEM; FEMALE; GENETIC SUSCEPTIBILITY; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN PRODUCTION; IMMUNOLOGICAL MEMORY; IMMUNOREGULATION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SPLENOMEGALY; SUPPRESSOR CELL; TH2 CELL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY FORMATION; ANTIBODY SPECIFICITY; ARTHRITIS; AUTOIMMUNE DISEASES; AUTOIMMUNITY; B-LYMPHOCYTES; COCULTURE TECHNIQUES; CROSS REACTIONS; FEMALE; FIBRINOGEN; HUMANS; HYBRIDOMAS; IMMUNIZATION; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN G; IMMUNOLOGIC MEMORY; INTERLEUKIN-2; INTERLEUKIN-4; LONGEVITY; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED DBA; RECEPTORS, INTERLEUKIN-2; RHEUMATOID FACTOR; SPLENOMEGALY; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; WHOLE BLOOD COAGULATION TIME;

EID: 21344449069     PISSN: 00088749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellimm.2005.03.005     Document Type: Article

References (45)

1. N.K. Jerne The somatic generation of immune recognition Eur. J. Immunol. 1 1971 1 10
2. C. Bouneaud, P Kourilsky, and P. Bousso Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion Immunity 13 2000 829 840
3. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state Int. Immunol. 10 1998 1969 1980
4. + suppressor T cells: more questions than answers Nat. Immunol. 2 2002 389 400
5. S.S. Wilson, P. van den Elzen, E. Maverakis, J.T. Beech, T.A. Braciak, V. Kumar, and E.E. Sercarz Residual public repertoires to self J. Neuroimmunol. 107 2000 233 239
6. B. Furie, and B.C. Furie The molecular basis of blood coagulation Cell 53 1998 505 517
7. D.I. Simon, A.M. Ezratty, S.A. Francis, H. Rennke, and J. Loscalzo Fibrin(ogen) is internalized and degraded by activated human monocytoid cells via Mac-1 (CD11b/CD18): a nonplasmin fibrinolytic pathway Blood 82 1993 2414 2422
8. P.Y. Perera, T.N. Mayadas, O. Takeuchi, S. Akira, M. Zaks-Zilberman, S.M. Goyert, and S.N. Vogel CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression J. Immunol. 166 2001 574 581
9. S.T. Smiley, J.A. King, and W.W. Hancock Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4 J. Immunol. 167 2001 2887 2894
10. C. Masson-Bessière, M. Sebbag, E. Girbal-Neuheuser, L. Nogueira, C. Vincent, T. Senshu, and G. Serre The major synovial targets of rheumatoid arthritis-specific anti-filaggrin autoantibodies are deiminated forms of the α and β chains of fibrin J. Immunol. 166 2001 4177 4184
11. E. Girbal-Neuheuser, J.J. Durieux, M. Arnaud, C. Vincent, L. Nogueira, and G. Serre The epitopes targeted by the rheumatoid arthritis-associated anti-fillagrin auto-antibodies are posttranslationally generated on various sites of (pro)-fillagrin by deimination of arginine residues J. Immunol. 162 1999 585 594
12. A. Suzuki, R. Yamada, and X. Chang Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis Nat. Genet. 34 2003 395 402
13. M. Lopez-Hoyos, R. Marquina, E. Tamayo, J. Gonzales-Rojas, S. Izui, R. Merino, and J. Merino Defects in the regulation of B cell apoptosis are required for the production of citrullinated peptide autoantibodies in mice Arthritis Rheum. 48 2003 2353 2361
14. E.R. Vossenaar, S. Nijenhuis, M.M.A. Helsen, A. van der Heijden, T. Senshu, W. van den Berg, W.J. van Venrooij, and L.A.B. Joosten Citrullination of synovial proteins in murine models of rheumatoid arthritis Arthritis Rheum. 48 2003 2489 2500
15. B. Rubin, and G. Sønderstrup Citrullination of self-proteins and autoimmunity Scand. J. Immunol. 60 2004 112 120
16. G.A. Schellekens, B.A.W. de Jong, F. van den Hoogen, L. van de Putte, and W. van Venrooij Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies J. Clin. Invest. 101 1998 273 281
17. P. Lee, G.R. Matsueda, and P.M. Allen T cell recognition of fibrinogen. A determinant on the Aα chain does not require processing J. Immunol. 140 1978 1063 1068
18. T. Atsumi, K. Ishihara, D. Kamimura, H. Ikushima, T. Ohtani, S. Hirota, H. Kobayashi, S.J. Park, Y. Saeki, Y. Kitamura, and T. Hirano A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis J. Exp. Med. 196 2002 979 990
19. B. Rubin, and A. Boned Insulin-specific T cell help to TNP-specific B cells requires activation via the antigen T cell receptor Eur. J. Immunol. 16 1986 1223 1229
20. D.D. Brand, T.N. Marion, L.K. Myers, F.F. Rosloniec, W.C. Watson, J.M. Stuart, and A.H. Kang Auto-antibodies to murine type II collagen in collagen-induced arthritis. A comparison of susceptible and non-susceptible strains J. Immunol. 157 1996 5178 5184
21. R. Holmdahl, M. Andersson, T.J. Goldschmidt, K. Gustafsson, L. Jansson, and J.A. Mo Type II collagen autoimmunity in animals and provocations leading to arthritis Immunol. Rev. 118 1990 193 232
22. A.P. Cope, S.D. Patel, F. Hall, M. Congia, H. Hubers, G.F. Verheijden, A.M.H. Boots, R. Menon, M. Trucco, A.W.M. Rijnders, and G. Sönderstrup T cell responses to a human cartilage autoantigen in the context of rheumatoid arthritis-associated and nonassociated HLA-DR4 alleles Arthritis Rheum. 42 1999 1497 1507
23. K. Hollo, T.T. Glant, M. Garzo, A. Finnegan, K. Mikecz, and E. Buzas Complex pattern of Th1 and Th2 activation with a preferential increase of auto-reactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)-induced arthritis Clin. Exp. Immunol. 120 2000 167 173
24. B.J. Hebeis, K. Klenovsek, P. Rohwer, U. Ritter, A. Schneider, M. Mach, and T.H. Winkler Activation of virus-specific memory B cells in the absence of T cell help J. Exp. Med. 199 2004 593 602
25. D. Kyburz, M. Corr, D.C. Brinson, A. Von Damm, H. Tighe, and D.A. Carson Human rheumatoid factor production is dependent on CD40 signaling and autoantigen J. Immunol. 163 1999 3116 3122
26. B. Rubin, and H. Wigzell The immune response to hapten-autologous protein conjugates in the mouse. III. Specificity of non-thymus processed (B) and thymus-processed (T) lymphocytes J. Exp. Med. 137 1973 911 931
27. + cell depletion hastens the onset of severe disease in collagen-induced arthritis Arthritis Rheum. 48 2003 1452 1460
28. E.E. Sercarz, and E. Maverakis MHC-guided processing: binding of large antigen fragments Nat. Rev. Immunol. 3 2003 621 629
29. M. Maccioni, G. Zeder-Lutz, H. Huang, C. Ebel, P. Gerber, J. Hergueux, P. Marchal, V. Duchatelle, C. Degott, M. van Regenmortel, C. Benoit, and D. Mathis Arthritogenic monoclonal antibodies from K/BxN mice J. Exp. Med. 195 2002 812 818
30. J.L. Grogan, A. Kramer, A. Nogai, L. Dong, M. Ohde, J. Schneider-Mergener, and T. Kamradt Cross-reactivity of myelin basic protein-specific T cells with multiple microbial peptides: experimental autoimmune encephalomyelitis induction in TCR transgenic mice J. Immunol. 163 1999 3764 3770
31. A.C. Anderson, L.B. Nicholson, K.L. Legge, V. Turchin, H. Zaghouani, and V.K. Kuchroo High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naïve mice: mechanisms of selection of the self-reactive repertoire J. Exp. Med. 191 2000 761 770
32. C.C. Norbury, and L.J. Sigal Cross priming or direct priming: Is that really the question? Curr. Opin. Immunol. 15 2003 82 88
33. R.M. Kedl, J.W. Kappler, and P. Marrack Epitope dominance, competition and T cell affinity maturation Curr. Opin. Immunol. 15 2003 120 127
34. B.T. Wipke, and P. Allen Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis J. Immunol. 167 2001 1601 1608
35. H. Ji, K. Ohmura, U. Mahmood, D.M. Lee, F.M.A. Hofhuis, S.A. Boackie, K. Takahashi, V.M. Holers, M. Walport, C. Gerard, A. Ezekowitz, M.C. Carroll, M. Brenner, R. Weissleder, J.S. Verbeek, V. Duchatelle, C. Degott, C. Benoit, and D. Mathis Arthritis critically dependent on innate immune system players Immunity 16 2002 157 168
36. S. Roth, N. Willcox, R. Rzepka, M.P. Mayer, and I. Melchers Major differences in antigen-processing correlate with a single arg->lys sunstitution in HLA-DR molecules predisposing to rheumatoid arthritis and with their selective interactions with 70-kDa heat shock protein chaperones J. Immunol. 169 2002 3015 3020
37. M. Durai, H.R. Kim, and K.D. Moudgil The regulatory C-terminal determinants within mycobacterial heat shock protein 65 are cryptic and cross-reactive with the dominant self homologs: implications for the pathogenesis of autoimmune arthritis J. Immunol. 173 2004 181 188
38. N.M. Parish, P.R. Hutchings, L. O'Reilly, R.Q. Papafio, D. Healey, P. Ozegbe, and A. Cooke Tolerance induction as a therapeutic strategy for the control of autoimmune endocrine disease in mouse models Immunol. Rev. 144 1995 269 300
39. C. Breithaupt, A. Schubart, H. Zander, A. Skerra, R. Huber, C. Linington, and U. Jacob Structural insights into the antigenecity of myelin oligodendrocyte glycoprotein Proc. Natl. Acad. Sci USA 100 2003 9446 9451
40. E.C. Andersson, B.E. Hansen, H. Jacobsen, L.S. Madsen, C.B. Andersen, J. Engberg, J.B. Rothbard, G.S. McDevitt, V. Malmström, R. Holmdahl, A. Svejgaard, and L. Fugger Definition of MHC and T cell receptor contacts in the HLA-DR4 restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice Proc. Natl. Acad. Sci. USA 95 1998 7574 7578
41. P.K. Gregersen, J. Silver, and R.J. Winchester The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis Arthritis Rheum. 30 1987 315 332
42. V. Taneja, and C.S. David HLA class II transgenic mice as models of human diseases Immunol. Rev. 169 1999 67 79
43. D.G. Millar, K.M. Garza, B. Odermatt, A.R. Elford, N. Ono, Z. Li, and P.S. Ohashi Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo Nat. Med. 3 2003 1469 1476
44. L. Reininger, J. Fueri, A. Boned, M. Prat, S. Landolfo, and B. Rubin On the molecular basis of T helper cell function. IV. B-lymphocyte promotor factors: on their mode of action, biochemical nature and possible relationship to molecules involved in specific T helper cell activity Cell. Immunol. 92 1985 85 104
45. P. Kalinski, and M. Moser Consensual immunity: success-driven development of Th1 and Th2 responses Nat. Rev. Immunol. 5 2005 251 260