Pathophysiology of acute pancreatitis: If you believe in mice - It's time for conditional gene targeting!

Digestion

Volumn 71, Issue 3, 2005, Pages 159-161

  Schmid, Roland M ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CYTOKINE; ENZYME PRECURSOR;

ACINAR CELL; ACUTE PANCREATITIS; AUTOIMMUNE DISEASE; CELL FUNCTION; CYTOKINE RELEASE; DISEASE MODEL; EDITORIAL; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; ENZYME ACTIVATION; HUMAN; MACROPHAGE; MORBIDITY; MORTALITY; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; DISEASE MODELS, ANIMAL; GENE TARGETING; MICE; PANCREATITIS, ACUTE NECROTIZING;

EID: 21344440525     PISSN: 00122823     EISSN: None     Source Type: Journal    
DOI: 10.1159/000086137     Document Type: Editorial

References (19)

1. Schmid RM, Adler G: Cytokines in acute pancreatitis: New pathophysiological concepts evolve. Eur J Gastroenterol Hepatol 1999;11:125-127.
2. Duan RD, Zheng CF, Guan KL, Williams JA: Activation of MAP kinase (MEK) and Ras by cholecystokinin in rat pancreatic acini. Am J Physiol 1995;268:G1060-G1065.
3. Dabrowski A, Grady T, Logsdon CD, Williams JA: Jun kinases are rapidly activated by cholecystokinin in rat pancreas both in vitro and in vivo. J Biol Chem 1996;271:5686-5690.
4. Steinle AU, Weidenbach H, Wagner M, Adler G, Schmid RM: Nuclear factor kappa B activation in cerulein pancreatitis. Gastroenterology 1998;116:420-430.
5. Tando Y, Algül H, Schneider G, Weber CK, Weidenbach H, Adler G, Schmid RM: Induction of IkappaB-kinase by cholecystokinin is mediated by trypsinogen activation in rat pancreatic lobules. Digestion 2002;66:237-245.
6. Schäfer C, Tietz AB, Göke B: Pathophysiology of acute experimental pancreatitis: Lessons from genetically engineered animal models and new molecular approaches. Digestion 2005;71:162-172.
7. Imamura T, Asada M, Vogt SK, Rudnick DA, Lowe ME, Muglia LJ: Protection from pancreatitis by the zymogen granule membrane protein integral membrane-associated protein-1. J Biol Chem 2002;277:50725-50733.
8. Suzuki S, Miyasaka K, Jimi A, Funakoshi A: Induction of acute pancreatitis by cerulein in human IL-6 gene transgenic mice. Pancreas 2000;21:86-92.
9. Cuzzocrea S, Mazzon E, Dugo L, Centorrino T, Ciccolo A, McDonald MC, de Sarro A, Caputi AP, Thiemermann C: Absence of endogenous interleukin-6 enhances the inflammatory response during acute pancreatitis induced by cerulein in mice. Cytokine 2002;18:274-285.
10. Sage J, Miller PA, Perez-Mancera, Wysocki JM, Jacks T: Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature 2003;424:223-228.
11. Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M: The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med 2003;9:575-581.
12. Orban PC, Chui D, Marth JD: Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci USA 1992;89:6861-6865.
13. Lakso M, Saur B, Mosinger B, Lee EJ, Manning RW, Yu SH, Mulder KL, Westphal H: Targeted oncogene activation by site-specific recombination in transgenic mice. Proc Natl Acad Sci USA 1992;89:6232-6236.
14. Rajewsky K, Gu H, Kühn R, Betz UAK, Müller W, Roes J, Schwenk F: Perspectives series: molecular medicine in genetically engineered animals: Conditional gene targeting. J Clin Invest 1996;98:600-6003.
15. Gu G, Dubauskaite J, Melton DA: Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-2457.
16. Gannon M, Herrera PL, Wright CV: Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter. Genesis 2000;26:143-144.
17. Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV: The role of the transcriptional regulator Ptfla in converting intestinal to pancreatic progenitors. Nat Genet 2002;32:128-134.
18. Grippo PJ, Nowlin PS, Cassaday RD, Sandgren EP: Cell-specific transgene expression from a widely transcribed promoter using Cre/lox in mice. Genesis 2002;32:277-286.
19. Herrera PL, Nepote V, Delacour A: Pancreatic cell lineage analyses in mice. Endocrine 2002;19:267-278.