Vascular endothelium-selective gene induction by Tie2 promoter/enhancer in the brain and retina of a transgenic rat

Pharmaceutical Research

Volumn 22, Issue 6, 2005, Pages 852-857

  Ohtsuki, Sumio ^a,b   Kamiya, Naoko ^a,b   Hori, Satoko ^a,b   Terasaki, Tetsuya ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Blood brain barrier; Green fluorescence protein; Inner blood retinal barrier; Tie2 promoter enhancer; Transgenic rats

Indexed keywords

ANGIOPOIETIN RECEPTOR; GLUCOSE TRANSPORTER 1; GREEN FLUORESCENT PROTEIN;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD RETINA BARRIER; BRAIN; BRAIN CAPILLARY; CAPILLARY ENDOTHELIUM; CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CYTOPLASM; ENDOTHELIUM CELL; ENHANCER REGION; FLUORESCENCE; GENE EXPRESSION; GENE INDUCTION; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; MICROINJECTION; NERVE CELL; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RETINA; RETINA CAPILLARY; TISSUE SLICE; TRANSGENIC ANIMAL; VASCULAR ENDOTHELIUM;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN CHEMISTRY; CAPILLARIES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; RATS; RECEPTOR, TIE-2; RETINA;

EID: 21244483145     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11095-005-4579-y     Document Type: Article

References (27)

1. S. Constable M. Pirmohamed 2004 Drugs and the retina Expert Opin. Drug Saf. 3 249 259
2. S. Ohtsuki 2004 New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system Biol. Pharm. Bull. 27 1489 1496
3. T. Terasaki K. Hosoya 1999 The blood-brain barrier efflux transporters as a detoxifying system for the brain Adv. Drug Deliv. Rev. 36 195 209
4. J. H. Lin M. Yamazaki 2003 Clinical relevance of P-glycoprotein in drug therapy Drug Metab. Rev. 35 417 454
5. T. Mikus M. Poplstein J. Sedlakova V. Landa G. Jenikova P. Trefil J. Lidicky P. Maly 2004 Generation and phenotypic analysis of a transgenic line of rabbits secreting active recombinant human erythropoietin in the milk Transgenic Res. 13 487 498
6. R. S. Prather P. Sutovsky J. A. Green 2004 Nuclear remodeling and reprogramming in transgenic pig production Exp. Biol. Med. (Maywood) 229 1120 1126
7. R. Takahashi M. Hirabayashi N. Yanai M. Obinata M. Ueda 1999 Establishment of SV40-tsA58 transgenic rats as a source of conditionally immortalized cell lines Exp. Anim. 48 255 261
8. T. Motoike S. Loughna E. Perens B. L. Roman W. Liao T. C. Chau C. D. Richardson T. Kawate J. Kuno B. M. Weinstein D. Y. Stainier T. N. Sato 2000 Universal GFP reporter for the study of vascular development Genesis 28 75 81
9. T. M. Schlaeger S. Bartunkova J. A. Lawitts G. Teichmann W. Risau U. Deutsch T. N. Sato 1997 Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice Proc. Natl. Acad. Sci. USA 94 3058 3063
10. K. Sakai H. Shimizu T. Koike S. Furuya M. Watanabe 2003 Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries J.Neurosci. 23 550 560
11. M. Tachikawa M. Fukaya T. Terasaki S. Ohtsuki M. Watanabe 2004 Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis Eur. J. Neurosci. 20 144 160
12. A. K. Kumagai S. A. Vinores W. M. Pardridge 1996 Pathological upregulation of inner blood-retinal barrier Glut1 glucose transporter expression in diabetes mellitus Brain Res. 706 313 317
13. K. Hosoya S. Hori S. Ohtsuki T. Terasaki 2004 A new in vitro model for blood-cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat Adv. Drug Deliv. Rev. 56 1875 1885
14. H. Ohashi H. Takagi S. Koyama H. Oh D. Watanabe D. A. Antonetti T. Matsubara K. Nagai H. Arai T. Kita Y. Honda 2004 Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats Mol. Vis. 10 608 617
15. H. Takagi S. Koyama H. Seike H. Oh A. Otani M. Matsumura Y. Honda 2003 Potential role of the angiopoietin/tie2 system in ischemia-induced retinal neovascularization Investig. Ophthalmol. Vis. Sci. 44 393 402
16. T. Nakashima M. Tomi K. Katayama M. Tachikawa M. Watanabe T. Terasaki K. Hosoya 2004 Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier J. Neurochem. 89 1454 1461
17. A. L. Wong Z. A. Haroon S. Werner M. W. Dewhirst C.S. Greenberg K. G. Peters 1997 Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues Circ. Res. 81 567 574
18. A. Tsuji 2004 Transporter-mediated drug interactions Drug Metab. Pharmacokinet. 17 253 274
19. T. Terasaki S. Ohtsuki S. Hori H. Takanaga E. Nakashima K. Hosoya 2003 New approaches to in vitro models of blood-brain barrier drug transport Drug Discov. Today 8 944 954
20. S. Hori S. Ohtsuki M. Ichinowatari T. Yokota T. Kanda T. Terasaki 2005 Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA J. Neurochem. 93 63 71
21. F. Amiri A. Virdis M. F. Neves M. Iglarz N. G. Seidah R. M. Touyz T. L. Reudelhuber E. L. Schiffrin 2004 Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction Circulation 110 2233 2240
22. Y. Y. Kisanuki R. E. Hammer J. Miyazaki S. C. Williams J. A. Richardson M. Yanagisawa 2001 Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo Dev. Biol. 230 230 242
23. K. Hosoya S. Ohtsuki T. Terasaki 2002 Recent advances in the brain-to-blood efflux transport across the blood-brain barrier Int. J. Pharm. 248 15 29
24. A. Kakee T. Terasaki Y. Sugiyama 1996 Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier J. Pharmacol. Exp. Ther. 277 1550 1559
25. C. H. Chau K. Y. Chen H. T. Deng K. J. Kim K. Hosoya T. Terasaki H. M. Shih D. K. Ann 2002 Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation Oncogene 21 8817 8829
26. S. Hori S. Ohtsuki K. Hosoya E. Nakashima T. Terasaki 2004 A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro J. Neurochem. 89 503 513
27. M. Tomi K. Hosoya H. Takanaga S. Ohtsuki T. Terasaki 2002 Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier Investig. Ophthalmol. Vis. Sci. 43 774 779