Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells

FEBS Letters

Volumn 579, Issue 17, 2005, Pages 3789-3796

  Abrescia, Chiara ^a   Sjöstrand, Dan ^a   Kjaer, Svend ^a,b   Ibáñez, Carlos F ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Development; Evolution; Glial cell line derived neurotrophic factor; Neuronal differentiation; Signaling

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR ALPHA; GROWTH FACTOR RECEPTOR; PROTEIN RET; PROTEIN TYROSINE KINASE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOCHEMISTRY; CELL ADHESION; CELL CULTURE; CELL STIMULATION; CELL STRAIN; CHIMERA; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; EXTRACELLULAR SPACE; GENETIC TRANSFECTION; INSECT CELL; MAMMAL CELL; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; ORTHOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CELL DIFFERENTIATION; DROSOPHILA PROTEINS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NEURONS; PC12 CELLS; PHOSPHORYLATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-RET; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECOMBINANT FUSION PROTEINS;

DANIO RERIO; INSECTA; MAMMALIA; RODENTIA; VERTEBRATA;

EID: 21244482590     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.05.075     Document Type: Article

References (33)

1. M. Takahashi, and G.M. Cooper Ret transforming gene encodes a fusion protein homologous to tyrosine kinases Mol. Cell. Biol. 7 1987 1378 1385
2. S. Manie, M. Santoro, A. Fusco, and M. Billaud The RET receptor: function in development and dysfunction in congenital malformation Trends Genet. 17 2001 580 589
3. M. Trupp Functional receptor for GDNF encoded by the c-ret proto-oncogene Nature 381 1996 785 789
4. J.J. Treanor Characterization of a multicomponent receptor for GDNF Nature 382 1996 80 83
5. S. Jing GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF Cell 85 1996 1113 1124
6. A. Schuchardt, V. D'Agati, L. Larsson-Blomberg, F. Costantini, and V. Pachnis Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret Nature 367 1994 380 383
7. M. Takahashi The GDNF/RET signaling pathway and human diseases Cytokine Growth Factor Rev. 12 2001 361 373
8. S.M. Jhiang The RET proto-oncogene in human cancers Oncogene 19 2000 5590 5597
9. J. Anders, S. Kjar, and C.F. Ibanez Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site J. Biol. Chem. 276 2001 35808 35817
10. A. Schuchardt, S. Srinivas, V. Pachnis, and F. Costantini Isolation and characterization of a chicken homolog of the c-ret proto-oncogene Oncogene 10 1995 641 649
11. C.V. Marcos-Gutierrez, S.W. Wilson, N. Holder, and V. Pachnis The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis Oncogene 14 1997 879 889
12. R. Sugaya, S. Ishimaru, T. Hosoya, K. Saigo, and Y. Emori A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells Mech. Dev. 45 1994 139 145
13. M. Hahn, and J. Bishop Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons Proc. Natl. Acad. Sci. USA 98 2001 1053 1058
14. G. Manning, D.B. Whyte, R. Martinez, T. Hunter, and S. Sudarsanam The protein kinase complement of the human genome Science 298 2002 1912 1934
15. F. Nollet, P. Kools, and F. van Roy Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members J. Mol. Biol. 299 2000 551 572
16. E. Hill, I.D. Broadbent, C. Chothia, and J. Pettitt Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster J. Mol. Biol. 305 2001 1011 1024
17. M.D. Adams The genome sequence of Drosophila melanogaster Science 287 2000 2185 2195
18. G.M. Rubin Comparative genomics of the eukaryotes Science 287 2000 2204 2215
19. C. Dahlqvist, A. Blokzijl, G. Chapman, A. Falk, K. Dannaeus, C.F. Ibanez, and U. Lendahl Functional notch signaling is required for BMP4-induced inhibition of myogenic differentiation Development 130 2003 6089 6099
20. S. Kjaer, and C.F. Ibanez Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET Hum. Mol. Genet. 12 2003 2133 2144
21. B.L. Hempstead, S.J. Rabin, L. Kaplan, S. Reid, L.F. Parada, and D.R. Kaplan Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation Neuron 9 1992 883 896
22. C. Kasper, H. Rasmussen, J.S. Kastrup, S. Ikemizu, E.Y. Jones, V. Berezin, E. Bock, and I.K. Larsen Structural basis of cell-cell adhesion by NCAM Nat. Struct. Biol. 7 2000 389 393
23. M. Santoro, W.T. Wong, P. Aroca, E. Santos, B. Matoskova, M. Grieco, A. Fusco, and P.P. di Fiore An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway Mol. Cell. Biol. 14 1994 663 675
24. Z. Chen, Y. Chai, L. Cao, A. Huang, R. Cui, C. Lu, and C. He Glial cell line-derived neurotrophic factor promotes survival and induces differentiation through the phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathway respectively in PC12 cells Neuroscience 104 2001 593 598
25. D. Beaujean, C. Rosenbaum, H.W. Muller, J.J. Willemsen, J. Lenders, and S.R. Bornstein Combinatorial code of growth factors and neuropeptides define neuroendocrine differentiation in PC12 cells Exp. Neurol. 184 2003 348 358
26. M.C. Bordeaux The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease EMBO J. 19 2000 4056 4063
27. M. Coulpier, J. Anders, and C.F. Ibanez Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival J. Biol. Chem. 277 2002 1991 1999
28. S. Kjaer, and C.F. Ibanez Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET J. Biol. Chem. 278 2003 47898 47904
29. M. Bibel, and Y.A. Barde Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system Genes Dev. 14 2000 2919 2937
30. A. Hidalgo Interactive nervous system development: control of cell survival in Drosophila Trends Neurosci. 25 2002 365 370
31. R. Cagan The signals that drive kidney development: a view from the fly eye Curr. Opin. Nephrol. Hypertens. 12 2003 11 17
32. M. Trupp, C. Raynoschek, N. Belluardo, and C.F. Ibáñez Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase Mol. Cell. Neurosci. 11 1998 47 63
33. G. Paratcha, F. Ledda, and C.F. Ibáñez The neural cell adhesion molecule NCAM is an aternative signaling receptor for GDNF family ligands Cell 113 2003 867 879