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Volumn 20, Issue 6, 2005, Pages 865-872

Expression of cytochrome P450 enzymes in hepatic organoid reconstructed by rat small hepatocytes

Author keywords

Enzyme activity; Extracellular matrix; Maturation; Progenitor cells; Proliferation

Indexed keywords

16ALPHA CYANOPREGNENOLONE; 3 METHYLCHOLANTHRENE; ALCOHOL; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CLOFIBRIC ACID; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B1; CYTOCHROME P450 2E1; CYTOCHROME P450 3A2; CYTOCHROME P450 4A1; DRUG METABOLIZING ENZYME; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MATRIGEL; PHENOBARBITAL;

EID: 21244455166     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2005.03804.x     Document Type: Article
Times cited : (13)

References (42)
  • 1
    • 0026766267 scopus 로고
    • Small cell colonies appear in the primary culture of adult rat hepatocytes in the presence of nicotinamide and epidermal growth factor
    • Mitaka T, Mikami M, Sattler GL, Pitot HC, Mochizuki Y. Small cell colonies appear in the primary culture of adult rat hepatocytes in the presence of nicotinamide and epidermal growth factor. Hepatology 1992; 16: 440-7.
    • (1992) Hepatology , vol.16 , pp. 440-447
    • Mitaka, T.1    Mikami, M.2    Sattler, G.L.3    Pitot, H.C.4    Mochizuki, Y.5
  • 2
    • 0027378990 scopus 로고
    • Effects of mitogens and co-mitogens on the formation of small-cell colonies in primary cultures of rat hepatocytes
    • Mitaka T, Norioka K, Nakamura T, Mochizuki Y. Effects of mitogens and co-mitogens on the formation of small-cell colonies in primary cultures of rat hepatocytes. J. Cell. Physiol. 1993; 157: 461-8.
    • (1993) J. Cell. Physiol. , vol.157 , pp. 461-468
    • Mitaka, T.1    Norioka, K.2    Nakamura, T.3    Mochizuki, Y.4
  • 4
    • 0032934277 scopus 로고    scopus 로고
    • Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells
    • Mitaka T, Sato F, Mizuguchi T, Yokono T, Mochizuki Y. Reconstruction of hepatic organoid by rat small hepatocytes and hepatic nonparenchymal cells. Hepatology 1999; 29: 111-25.
    • (1999) Hepatology , vol.29 , pp. 111-125
    • Mitaka, T.1    Sato, F.2    Mizuguchi, T.3    Yokono, T.4    Mochizuki, Y.5
  • 5
    • 0036352361 scopus 로고    scopus 로고
    • Morphological changes induced by extracellular matrix are correlated with maturation of rat small hepatocytes
    • Sugimoto S, Mitaka T, Ikeda S et al. Morphological changes induced by extracellular matrix are correlated with maturation of rat small hepatocytes. J. Cell. Biochem. 2002; 87: 16-28.
    • (2002) J. Cell. Biochem. , vol.87 , pp. 16-28
    • Sugimoto, S.1    Mitaka, T.2    Ikeda, S.3
  • 6
    • 0035206350 scopus 로고    scopus 로고
    • Expression of carbamoylphosphate synthetase I and glutamine synthetase in hepatic organoids reconstructed by rat small hepatocytes and hepatic nonparenchymal cells
    • Mitaka T, Sato F, Ikeda S, Sugimoto S, Higaki N, Hirata K. Expression of carbamoylphosphate synthetase I and glutamine synthetase in hepatic organoids reconstructed by rat small hepatocytes and hepatic nonparenchymal cells. Cell Tissue Res. 2001; 306: 467-71.
    • (2001) Cell Tissue Res. , vol.306 , pp. 467-471
    • Mitaka, T.1    Sato, F.2    Ikeda, S.3    Sugimoto, S.4    Higaki, N.5    Hirata, K.6
  • 7
    • 0025307009 scopus 로고
    • Mechanisms of cytochrome P-450 catalysis
    • Guengerich FP, MacDonald TL. Mechanisms of cytochrome P-450 catalysis. FASEB J. 1990; 4: 2453-9.
    • (1990) FASEB J. , vol.4 , pp. 2453-2459
    • Guengerich, F.P.1    MacDonald, T.L.2
  • 8
    • 0028272001 scopus 로고
    • Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins
    • Gonzalez FJ, Gelboin HV. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab. Rev. 1994; 26: 165-83.
    • (1994) Drug Metab. Rev. , vol.26 , pp. 165-183
    • Gonzalez, F.J.1    Gelboin, H.V.2
  • 9
    • 0026750647 scopus 로고
    • The human hepatic cytochromes P450 involved in drug metabolism
    • Wrighton SA, Stevens JC. The human hepatic cytochromes P450 involved in drug metabolism. Crit. Rev. Toxicol. 1992; 22: 1-21.
    • (1992) Crit. Rev. Toxicol. , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 10
    • 0019226759 scopus 로고
    • Phenotypic stability of adult rat hepatocytes in primary monolayer culture
    • Bissell DM, Guzelian PS. Phenotypic stability of adult rat hepatocytes in primary monolayer culture. Ann. NY Acad. Sci. 1980; 349: 85-98.
    • (1980) Ann. NY Acad. Sci. , vol.349 , pp. 85-98
    • Bissell, D.M.1    Guzelian, P.S.2
  • 11
    • 0016333916 scopus 로고
    • Ethoxyresorufin: Direct fluorimetric assay of a microsomal o-dealkylation which is preferentially inducible by 3-methylcholanthrene
    • Burke MD, Mayer RT. Ethoxyresorufin: direct fluorimetric assay of a microsomal o-dealkylation which is preferentially inducible by 3-methylcholanthrene. Drug Metab. Dispos. 1974; 2: 583-8.
    • (1974) Drug Metab. Dispos. , vol.2 , pp. 583-588
    • Burke, M.D.1    Mayer, R.T.2
  • 12
    • 0028860836 scopus 로고
    • Species and sex differences of testosterone and nifedipine oxidation in liver microsomes of rat, dog and monkey
    • Niwa T, Kaneko H, Naritomi Y et al. Species and sex differences of testosterone and nifedipine oxidation in liver microsomes of rat, dog and monkey. Xenobiotica 1995; 25: 1041-9.
    • (1995) Xenobiotica , vol.25 , pp. 1041-1049
    • Niwa, T.1    Kaneko, H.2    Naritomi, Y.3
  • 13
    • 0030894106 scopus 로고    scopus 로고
    • Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species
    • Court MH, Von Moltke LL, Shader RI, Greenblatt DJ. Biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. Biopharm. Drug Dispos. 1997; 18: 213-26.
    • (1997) Biopharm. Drug Dispos. , vol.18 , pp. 213-226
    • Court, M.H.1    Von Moltke, L.L.2    Shader, R.I.3    Greenblatt, D.J.4
  • 14
    • 0028807011 scopus 로고
    • The influence of medium composition on the maintenance of cytochrome P-450, glutathione content and urea synthesis: A comparison of rat and sheep primary hepatocyte cultures
    • Watts P, Smith MD, Edwards I, Zammit V, Brown V, Grant H. The influence of medium composition on the maintenance of cytochrome P-450, glutathione content and urea synthesis: a comparison of rat and sheep primary hepatocyte cultures. J. Hepatol. 1995; 23: 605-12.
    • (1995) J. Hepatol. , vol.23 , pp. 605-612
    • Watts, P.1    Smith, M.D.2    Edwards, I.3    Zammit, V.4    Brown, V.5    Grant, H.6
  • 15
    • 0003001586 scopus 로고    scopus 로고
    • Biotransformation of drugs by hepatocytes
    • Castell JV, Gomez-Lechon MJ, eds. London: Academic Press
    • Guillouzo A. Biotransformation of drugs by hepatocytes. In: Castell JV, Gomez-Lechon MJ, eds. In Vitro Methods in Pharmaceutical Research. London: Academic Press, 1997; 411-31.
    • (1997) In Vitro Methods in Pharmaceutical Research , pp. 411-431
    • Guillouzo, A.1
  • 16
    • 0027460346 scopus 로고
    • Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel
    • Kocarek TA, Schuetz EG, Guzelian PS. Expression of multiple forms of cytochrome P450 mRNAs in primary cultures of rat hepatocytes maintained on matrigel. Mol. Pharmacol. 1993; 43: 328-34.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 328-334
    • Kocarek, T.A.1    Schuetz, E.G.2    Guzelian, P.S.3
  • 17
    • 0031943842 scopus 로고    scopus 로고
    • Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B in primary cultured rat hepatocytes
    • Woodcroft KJ, Novak RF. Xenobiotic-enhanced expression of cytochrome P450 2E1 and 2B in primary cultured rat hepatocytes. Drug Metab. Dispos. 1998; 26: 372-8.
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 372-378
    • Woodcroft, K.J.1    Novak, R.F.2
  • 18
    • 0026547439 scopus 로고
    • Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation
    • Dunn JCY, Tompkins RG, Yarmush ML. Hepatocytes in collagen sandwich: evidence for transcriptional and translational regulation. J. Cell Biol. 1992; 116: 1043-53.
    • (1992) J. Cell Biol. , vol.116 , pp. 1043-1053
    • Dunn, J.C.Y.1    Tompkins, R.G.2    Yarmush, M.L.3
  • 19
    • 0028124710 scopus 로고
    • Use of organotypical cultures of primary hepatocytes to analyze drug biotransformation in man and animals
    • Bader A, Zech K, Crome O et al. Use of organotypical cultures of primary hepatocytes to analyze drug biotransformation in man and animals. Xenobiotica 1994; 24: 623-33.
    • (1994) Xenobiotica , vol.24 , pp. 623-633
    • Bader, A.1    Zech, K.2    Crome, O.3
  • 20
    • 0028209259 scopus 로고
    • Collagen gel immobilization: A useful cell culture technique for long-term metabolic studies on human hepatocytes
    • Koebe HG, Pahernik S, Eyer P, Schildberg FW. Collagen gel immobilization: a useful cell culture technique for long-term metabolic studies on human hepatocytes. Xenobiotica 1994; 24: 95-107.
    • (1994) Xenobiotica , vol.24 , pp. 95-107
    • Koebe, H.G.1    Pahernik, S.2    Eyer, P.3    Schildberg, F.W.4
  • 21
    • 0029884129 scopus 로고    scopus 로고
    • Functional maintenance of hepatocytes on collagen gel cultured with simple serum-free medium containing sodium selenite
    • Nakajima H, Shinbara N. Functional maintenance of hepatocytes on collagen gel cultured with simple serum-free medium containing sodium selenite. Biochem. Biophys. Res. Commun. 1996; 222: 664-8.
    • (1996) Biochem. Biophys. Res. Commun. , vol.222 , pp. 664-668
    • Nakajima, H.1    Shinbara, N.2
  • 22
    • 14444274090 scopus 로고    scopus 로고
    • Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix
    • Gómez-Lechón MJ, Jover R, Donato T et al. Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix. J. Cell Physiol. 1998; 177: 553-62.
    • (1998) J. Cell Physiol. , vol.177 , pp. 553-562
    • Gómez-Lechón, M.J.1    Jover, R.2    Donato, T.3
  • 23
    • 0023090714 scopus 로고
    • Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver
    • Bissel DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. J. Clin. Invest. 1987; 79: 801-12.
    • (1987) J. Clin. Invest. , vol.79 , pp. 801-812
    • Bissel, D.M.1    Arenson, D.M.2    Maher, J.J.3    Roll, F.J.4
  • 24
    • 0029610436 scopus 로고
    • Critical role of the extracellular matrix on induction by phenobarbital of cytochrome P450 2B1/2 in primary cultures of adult rat hepatocytes
    • Brown SE, Guzelian CP, Schuetz E, Quattrochi LC, Kleinman HK, Guzelian PS. Critical role of the extracellular matrix on induction by phenobarbital of cytochrome P450 2B1/2 in primary cultures of adult rat hepatocytes. Lab. Invest. 1995; 73: 818-27.
    • (1995) Lab. Invest. , vol.73 , pp. 818-827
    • Brown, S.E.1    Guzelian, C.P.2    Schuetz, E.3    Quattrochi, L.C.4    Kleinman, H.K.5    Guzelian, P.S.6
  • 25
    • 0029053925 scopus 로고
    • Regulation of hepatic genes and liver transcription factors in rat hepatocytes by extracellular matrix
    • Nagaki M, Shidori Y, Yamada Y et al. Regulation of hepatic genes and liver transcription factors in rat hepatocytes by extracellular matrix. Biochem. Biophys. Res. Commun. 1995; 210: 38-43.
    • (1995) Biochem. Biophys. Res. Commun. , vol.210 , pp. 38-43
    • Nagaki, M.1    Shidori, Y.2    Yamada, Y.3
  • 26
    • 0029165729 scopus 로고
    • Laminin-rich extracellular matrix maintains high level of hepatocyte nuclear factor 4 in rat hepatocyte culture
    • Oda H, Nozawa K, Hitomi Y, Kakinuma A. Laminin-rich extracellular matrix maintains high level of hepatocyte nuclear factor 4 in rat hepatocyte culture. Biochem. Biophys. Res. Commun. 1995; 212: 800-5.
    • (1995) Biochem. Biophys. Res. Commun. , vol.212 , pp. 800-805
    • Oda, H.1    Nozawa, K.2    Hitomi, Y.3    Kakinuma, A.4
  • 27
    • 0034803066 scopus 로고    scopus 로고
    • Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions
    • Hamilton GA, Jolley SL, Gilbert D, Coon DJ, Barros S, LeCluyse EL. Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions. Cell Tissue Res. 2001; 306: 85-99.
    • (2001) Cell Tissue Res. , vol.306 , pp. 85-99
    • Hamilton, G.A.1    Jolley, S.L.2    Gilbert, D.3    Coon, D.J.4    Barros, S.5    Lecluyse, E.L.6
  • 28
    • 0025249973 scopus 로고
    • The maintenance of cytochrome P-450 in rat hepatocyte culture: Some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system
    • Paine AJ. The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system. Chem. Biol. Interact. 1990; 74: 1-31.
    • (1990) Chem. Biol. Interact. , vol.74 , pp. 1-31
    • Paine, A.J.1
  • 29
    • 0026516652 scopus 로고
    • Evidence that the loss of rat liver cytochrome P-450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix
    • Wright MC, Paine AJ. Evidence that the loss of rat liver cytochrome P-450 in vitro is not solely associated with the use of collagenase, the loss of cell-cell contacts and/or the absence of an extracellular matrix. Biochem. Pharmacol. 1992; 43: 237-43.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 237-243
    • Wright, M.C.1    Paine, A.J.2
  • 30
    • 0031940804 scopus 로고    scopus 로고
    • Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes
    • Chauret N, Gauthier A, Nicoll-Griffith DA. Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes. Drug Metab. Dispos. 1998; 26: 1-4.
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 1-4
    • Chauret, N.1    Gauthier, A.2    Nicoll-Griffith, D.A.3
  • 31
    • 0031921010 scopus 로고    scopus 로고
    • Evaluation of the selectivity of in vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities
    • Hickman D, Wang J-P, Wang Y, Unadkat JD. Evaluation of the selectivity of in vitro probes and suitability of organic solvents for the measurement of human cytochrome P450 monooxygenase activities. Drug Metab. Dispos. 1998; 26: 207-15.
    • (1998) Drug Metab. Dispos. , vol.26 , pp. 207-215
    • Hickman, D.1    Wang, J.-P.2    Wang, Y.3    Unadkat, J.D.4
  • 32
    • 0345490845 scopus 로고    scopus 로고
    • Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of CDNA-expressed human cytochromes P-450
    • Busby WF, Ackermann JM, Crespi CL. Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of CDNA-expressed human cytochromes P-450. Drug Metab. Dispos. 1999; 27: 246-9.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 246-249
    • Busby, W.F.1    Ackermann, J.M.2    Crespi, C.L.3
  • 34
    • 0029962261 scopus 로고    scopus 로고
    • Liver-enriched transcription factors and hepatocyte differentiation
    • Cereghini S. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J. 1996; 10: 267-82.
    • (1996) FASEB J. , vol.10 , pp. 267-282
    • Cereghini, S.1
  • 35
    • 0029820670 scopus 로고    scopus 로고
    • Constitutive expression of hepatic cytochrome P450 genes
    • Gonzalez FJ, Lee YH. Constitutive expression of hepatic cytochrome P450 genes. FASEB J. 1996; 10: 1112-17.
    • (1996) FASEB J. , vol.10 , pp. 1112-1117
    • Gonzalez, F.J.1    Lee, Y.H.2
  • 36
    • 0028898120 scopus 로고
    • Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene
    • Liu SY, Gonzalez FJ. Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene. DNA Cell Biol. 1995; 14: 285-93.
    • (1995) DNA Cell Biol. , vol.14 , pp. 285-293
    • Liu, S.Y.1    Gonzalez, F.J.2
  • 37
    • 0032958163 scopus 로고    scopus 로고
    • Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes
    • Madan A, Dehaan R, Mudra D, Carroll K, Lecluyse E, Parkinson A. Effect of cryopreservation on cytochrome P-450 enzyme induction in cultured rat hepatocytes. Drug Metab. Dispos. 1999; 27: 327-35.
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 327-335
    • Madan, A.1    Dehaan, R.2    Mudra, D.3    Carroll, K.4    Lecluyse, E.5    Parkinson, A.6
  • 38
    • 0025073482 scopus 로고
    • Transcriptional control of the rat hepatic CYP2E1 gene
    • Ueno T, Gonzalez FJ. Transcriptional control of the rat hepatic CYP2E1 gene. Mol. Cell. Biol. 1990; 10: 4495-505.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 4495-4505
    • Ueno, T.1    Gonzalez, F.J.2
  • 39
    • 0025873457 scopus 로고
    • Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine
    • Lemire JM, Shiojiri N, Fausto N. Oval cell proliferation and the origin of small hepatocytes in liver injury induced by D-galactosamine. Am. J. Pathol. 1991; 139: 535-52.
    • (1991) Am. J. Pathol. , vol.139 , pp. 535-552
    • Lemire, J.M.1    Shiojiri, N.2    Fausto, N.3
  • 40
    • 0029034469 scopus 로고
    • Participation of small intraportal stem cells in the restitutive response to periportal injury induced by allyl alcohol
    • Yavorkovsky L, Lai E, Ilic Z, Sell S. Participation of small intraportal stem cells in the restitutive response to periportal injury induced by allyl alcohol. Hepatology 1995; 21: 1702-12.
    • (1995) Hepatology , vol.21 , pp. 1702-1712
    • Yavorkovsky, L.1    Lai, E.2    Ilic, Z.3    Sell, S.4
  • 41
    • 0034492976 scopus 로고    scopus 로고
    • Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats
    • Gordon GJ, Coleman WB, Grisham JW. Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats. Am. J. Pathol. 2000; 157: 771-86.
    • (2000) Am. J. Pathol. , vol.157 , pp. 771-786
    • Gordon, G.J.1    Coleman, W.B.2    Grisham, J.W.3
  • 42
    • 0033902798 scopus 로고    scopus 로고
    • Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury
    • Braun KM, Sandgren EP. Cellular origin of regenerating parenchyma in a mouse model of severe hepatic injury. Am. J. Pathol. 2000; 157: 561-9.
    • (2000) Am. J. Pathol. , vol.157 , pp. 561-569
    • Braun, K.M.1    Sandgren, E.P.2


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