Animal models and their limitations: On the problem of high-to-low dose extrapolations following inhalation exposures

Experimental and Toxicologic Pathology

Volumn 57, Issue SUPPL. 1, 2005, Pages 143-146

  Gerde, Per ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Animal models; Inhalation exposure; Local dose response and saturation; Microdosimetry

Indexed keywords

ENZYME; POLYCYCLIC AROMATIC HYDROCARBON; VOLATILE AGENT;

ABSORPTION; AEROSOL; COMBUSTION; CONCENTRATION RESPONSE; DISSOLUTION; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVATION; ENZYME SUBSTRATE; EXPERIMENTAL MODEL; INHALATION; LIPOPHILICITY; LIVER METABOLISM; LONG TERM EXPOSURE; LUNG ALVEOLUS CELL TYPE 1; LUNG CANCER; LUNG TOXICITY; MICRODOSIMETRY; NONHUMAN; RESPIRATORY TRACT INFLAMMATION; RESPIRATORY TRACT MUCOSA; REVIEW; RISK ASSESSMENT; SOLUBILITY; SOLUTE; SYSTEMIC CIRCULATION;

ANIMALIA;

EID: 21244452655     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2005.05.016     Document Type: Article

References (19)

1. B. Armstrong, C. Tremblay, D. Baris, and G. Thériault Lung cancer mortality and polynuclear aromatic hydrocarbons: a case-cohort study of aluminium production workers in Arvida, Quebec, Canada Am J Epidemiol 139 1994 250 262
2. A.E. Aust, J.C. Ball, A.A. Hu, J.S. Lighty, K.R. Smith, A.M. Straccia, J.M. Veranth, and W.C. Young Particle characteristics responsible for effects on human lung epithelial cells 2002 Health Effects Institute Cambridge, MA
3. C.-E. Boström, P. Gerde, A. Hanberg, B. Jernström, C. Johansson, T. Kyrklund, A. Rannug, M. Törnqvist, K. Victorin, and R.N. Westerholm Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air Environ Health Perspect 110 Suppl. 3 2002 451 489
4. E.J. Calabrese Hormesis: from marginalization to mainstream: a case for hormesis as the default dose-response model in risk assessment Toxicol Appl Pharmacol 197 2 2004 125 136
5. R.B. Conolly, J.S. Kimbell, D. Janszen, P.M. Schlosser, D. Kalisak, J. Preston, and F.J. Miller Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically motivated computational modeling of a combined rodent and human dataset Toxicol Sci 82 1 2004 279 296
6. R.B. Conolly, and W.K. Lutz Nonmonotonic dose-response relationships: mechanistic basis, kinetic modeling, and implications for risk assessment Toxicol Sci 77 1 2004 151 157
7. M.F. Denissenko, A. Pao, M.-S. Tang, and G.P. Pfeifer Preferential formation of benzo(a)pyrene adducts at lung cancer mutational hotspots in p53 Science 274 1996 430 432
8. K. Donaldson, V. Stone, P.J. Borm, L.A. Jimenez, P.S. Gilmour, R.P. Schins, A.M. Knaapen, I. Rahman, S.P. Faux, D.M. Brown, and W. MacNee Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10) Free Radic Biol Med 34 11 2003 1369 1382
9. S.H. Gavett, and H.S. Koren The role of particulate matter in exacerbation of atopic asthma Int Arch Allergy Immunol 124 1-3 2001 109 112
10. P. Gerde, and B.R. Scott A model for absorption of low-volatile toxicants by the airway mucosa Inhal Toxicol 13 10 2001 903 929
11. P. Gerde, M.A. Medinsky, and J.A. Bond The retention of polycyclic aromatic hydrocarbons in the bronchial airways and in the alveolar region - a theoretical comparison Toxicol Appl Pharmacol 107 1991 239 252
12. P. Gerde, B.A. Muggenburg, J.R. Thornton-Manning, J.L. Lewis, K.H. Pyon, and A.R. Dahl Benzo(a)pyrene at an environmentally relevant dose is slowly absorbed by, and extensively metabolized in, tracheal epithelium Carcinogenesis 18 9 1997 1825 1832
13. P. Gerde, B.A. Muggenburg, M. Lundblad, and A.R. Dahl The rapid alveolar absorption of diesel-soot adsorbed benzo(a)pyrene-Bioavailability, metabolism, and dosimetry of an inhaled carcinogen Carcinogenesis 22 5 2001 741 749
14. A.M. Knaapen, P.J. Borm, C. Albrecht, and R.P. Schins Inhaled particles and lung cancer. Part A: mechanisms Int J Cancer 109 6 2004 799 809
15. A.E. Nel, D. Diaz-Sanchez, and N. Li The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress Curr Opin Pulm Med 7 1 2001 20 26
16. F. Nyberg, P. Gustavsson, L. Jarup, T. Bellander, N. Berglind, R. Jakobsson, and G. Pershagen Urban air pollution and lung cancer in Stockholm Epidemiology 11 5 2000 487 495
17. S. Olin W. Farland C. Park L. Rhomberg R. Scheuplin T. Starr J. Wilson Low-dose extrapolation of cancer risks: issues and perspectives 1995 ILSI Washington, DC
18. C.A. Pope III, R.T. Burnett, M.J. Thun, E.E. Calle, D. Krewski, K. Ito, and G.D. Thurston Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution JAMA 287 9 2002 1132 1141
19. P. Vineis, M. Alavanja, and S. Garte Dose-response relationship in tobacco-related cancers of bladder and lung: a biochemical interpretation Int J Cancer 108 1 2004 2 7