Lack of association between polymorphism of the human cyclic GMP-dependent protein kinase gene and obesity

International Journal of Obesity

Volumn 29, Issue 7, 2005, Pages 872-874

  Zakharkin, S O ^a   Belay, A T ^b   Fernandez, J R ^a   De Luca, V ^b   Kennedy, J L ^b   Sokolowski, M B ^b   Allison, D B ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Association study; cGMP dependent protein kinase; Polymorphism; PRKG1

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DEMOGRAPHY; ETHNOLOGY; EUROPEAN AMERICAN; GENE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PRKG1 GENE; UNITED STATES;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; FEMALE; GENOTYPE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC;

EID: 21244450712     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0802973     Document Type: Article

References (20)

1. Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB. Annual deaths attributable to obesity in the United States. JAMA 1999; 282: 1530-1538.
2. Rosmond R. Association studies of genetic polymorphisms in central obesity: a critical review. Int J Obes Relat Metab Disord 2003; 27: 1141-1151.
3. Hofmann F, Ammendola A, Schlossmann J. Rising behind NO: cGMP-dependent protein kinases. J Cell Sci. 2000; 113 (Part 10): 1671-1676.
4. Osborne KA, Robichon A, Burgess E, Rutland S, Shaw RA, Coulthard A, Pereira HS, Greenspan JR, Sokolowski MB. Natural behavior polymorphism due to a cGMP-dependent protein kinase of Drosophila. Science 1997; 277: 834-836.
5. Ben-Shahar Y, Robichon A, Sokolowski MB, Robinson GE. Influence of gene action across different time scales on behavior. Science 2002; 296: 741-744.
6. Fujiwara M, Sengupta P, McIntire SL. Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase. Neuron 2002; 36: 1091-1102.
7. Wilding JP. Neuropeptides and appetite control. Diabet Med 2002; 19: 619-627.
8. Fitzpatrick M, Sokolowski MB. In search of food: prospects regarding the evolutionary link between cGMP dependent protein kinase (PKG) and behavior. Integr Comp Biol 2004; 44: 28-36.
9. De Luca V, Muglia P, Jain U, Basile VS, Sokolowski MB, Kennedy JL. A Drosophila model for attention deficit hyperactivity disorder (ADHD): no evidence of association with PRKG1 gene. Neuromol Med 2002; 2: 281-287.
10. Ruth P. Cyclic GMP-dependent protein kinases: understanding in vivo functions by gene targeting. Pharmacol Ther 1999; 82: 355-372.
11. Hedlund P, Aszodi A, Pfeifer A, Alm P, Hofmann F, Ahmad M, Fassler R, Andersson KE. Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice. Proc Natl Acad Sci USA 2000; 97: 2349-2354.
12. Ny L, Pfeifer A, Aszodi A, Ahmad M, Alm P, Hedlund P, Fassler R, Andersson KE. Impaired relaxation of stomach smooth muscle in mice lacking cyclic GMP-dependent protein kinase 1. Br J Pharmacol 2000; 129: 395-401.
13. Garcia-Villafranca J, Guillen A, Castro J. Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes. Biochem Pharmacol 2003; 65: 807-812.
14. Su J, Zhang S, Tse J, Scholz PM, Weiss HR. Alterations in nitric oxide-cGMP pathway in ventricular myocytes from obese leptin-deficient mice. Am J Physiol Heart Circ Physiol 2003; 285: H2111-H2117.
15. Schafer WR. PKG and the neural basis for behavioral phenotypes. Neuron 2002; 36: 991-993.
16. Sokolowski MB. NPY and the regulation of behavioral development. Neuron 2003; 39: 6-8.
17. Wu Q, Wen T, Lee G, Park JH, Cai HN, Shen P. Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system. Neuron 2003; 39: 147-161.
18. Shen P, Cai HN. Drosophila neuropeptide F mediates integration of chemosensory stimulation and conditioning of the nervous system by food. J Neurobiol 2001; 47: 16-25.
19. Weir BS, Hill WG, Cardon LR. Allelic association patterns for a dense SNP map. Genet Epidemiol 2004; 27: 442-450.
20. The International HapMap Consortium. The International HapMap Project. Nature 2003; 426: 789-796.