Medroxyprogesterone acetate and dihydrotestosterone induce coronary hyperreactivity in intact male rhesus monkeys

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 6, 2005, Pages 3706-3714

  Mishra, Rajesh G ^a   Hermsmeyer, R Kent ^a   Miyagawa, Koichi ^c   Sarrel, Philip ^d   Uchida, Barry ^b   Stanczyk, Frank Z ^e   Burry, Kenneth A ^b   Illingworth, D Roger ^b   Nordt, Frank J ^f  

^a Dimera Incorporated   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c Department of Internal Medicine   (Japan)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f Rhein Consulting Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANDROGEN RECEPTOR; ANDROSTANOLONE; ANTIANDROGEN; FLUTAMIDE; MEDROXYPROGESTERONE ACETATE; MIFEPRISTONE; PROGESTERONE RECEPTOR; PROSTANOID RECEPTOR; SEROTONIN; THROMBOXANE A2;

ANGIOCARDIOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY DISEASE; FEMALE; IMMUNOCYTOCHEMISTRY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION; WESTERN BLOTTING; ANIMAL; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; DRUG EFFECT; MACACA; PHYSIOLOGY;

MACACA MULATTA; PRIMATES;

ANIMALS; CORONARY CIRCULATION; CORONARY VESSELS; DIHYDROTESTOSTERONE; MACACA MULATTA; MALE; MEDROXYPROGESTERONE 17-ACETATE; MUSCLE, SMOOTH, VASCULAR;

EID: 21244434384     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-1557     Document Type: Article

References (55)

1. Hermsmeyer RK, Miyagawa K, Kelley ST, Rösch J, Hall AS, Axthelm MK, Greenberg B 1997 Reactivity based coronary vasospasm independent of atherosclerosis in rhesus monkeys. J Am Col Cardiol 29:671-680
2. Hermsmeyer RK, Mishra RG, Pavcnik D, Uchida B, Axthelm MK, Stanczyk FZ, Burry KA, Illingworth R, Kaski JC, Nordt FJ 2004 Prevention of coronary hyperreactivity in pre-atherogenic menopausal rhesus monkeys by transdermal progesterone. Arterioscler Thromb Vasc Biol 24:955-961
3. Clarkson TB, Appt SE 2003 MPA and postmenopausal artery atherosclerosis revisited. Steroids 68:941-951
4. Miyagawa K, Rösch J, Stanczyk F, Hermsmeyer RK 1997a Medroxyprogesterone interferes with ovarian steroid protection against coronary vasospasm. Nat Med 3:324-327
5. Adams MR, Register TC, Golden DL, Wagner JD, Williams JK 1997 Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis. Arterioscler Thromb Vasc Biol 17:217-221
6. Minshall RD, Stanczyk FZ, Miyagawa K, Uchida B, Axthelm MK, Novy M, Hermsmeyer RK 1998 Ovarian steroid protection against coronary artery hyperreactivity in rhesus monkeys. J Clin Endocrinol Metab 83:649-659
7. Minshall RD, Miyagawa K, Chadwick CC, Novy MJ, Hermsmeyer RK 1998 In vitro modulation of primate coronary vascular muscle cell reactivity by ovarian steroid hormones. FASEB J 12:1419-1429
8. 2 receptors in rhesus monkeys. Am J Physiol 281:H1498-H1507
9. Grady D, Herrington D, Bittner V, Blumenthal R, Davidson M, Hlatky M, Hsia J, Hulley S, Herd A, Khan S, Newby LK, Waters D, Vittinghoff E, Wenger N 2002 Cardiovascular disease outcomes during 6.8 years of hormone therapy: Heart and Estrogen/Progestin Replacement Study follow-up (HERSII). JAMA 288:49-57
10. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J 2002 Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 288:321-333
11. Wakatsuki A, Okatani Y, Ikenoue N, Fukaya T 2002 Effect of medroxyprogesterone acetate on vascular inflammatory markers in postmenopausal women receiving estrogen. Circulation 105:1436-1469
12. Adams MR, Kaplan JR, Manuck SB, Koritnik DR, Parks JS, Wolfe MS, Clarkson TB 1990 Inhibition of coronary artery atherosclerosis by 17-β estradiol in ovariectomized monkeys. Lack of an effect of added progesterone. Arteriosclerosis 10:1051-1057
13. Zumpe D, Bonsall RW, Kutner MH, Michael RP 1991 Medroxyprogesterone acetate, aggression, and sexual behavior in male cynomolgus monkeys (Macaca fascicularis). Horm Behav 25:394-409
14. Cooper AJ 1986 Progestogens in the treatment of male sex offenders: a review. Can J Psychiatry 31:73-79
15. Kiersch TA 1990 Treatment of sex offenders with Depo-Provera. Bull Am Acad Psychiatry Law 18:179-187
16. Turner L, Conway AW, Jimenez M, Liu PY, Forbes E, McLachlan RI, Handelsman DJ 2003 Contraceptive efficacy of a depot progestin and androgen combination in men. J Clin Endocrinol Metab 88:4659-4667
17. Perachio AA, Alexander M, Marr LD, Collins DC 1977 Diurnal variations of serum testosterone levels in intact and gonadectomized male and female rhesus monkeys. Steroids 29:21-33
18. Resko JA, Jackson GL, Huckins C, Stadelman H, Spies HG 1980 Cryptorchid rhesus macaques: long term studies on changes in gonadotropins and gonadal steroids. Endocrinology 107:1127-1136
19. Hess DL, Spies HG, Hendrickx AG 1981 Diurnal steroid patterns during gestation in the rhesus macaque: onset, daily variation, and the effects of dexamethasone treatment. Biol Reprod 24:609-616
20. Hiroi M, Stanczyk FZ, Goebelsmann U, Brenner PF, Lumkin ME, Mishell Jr DR1975 Radioimmunoassay of serum medroxyprogesterone acetate (Provera) in women following oral and intravaginal administration. Steroids 26:373-386
21. 2+ release mechanism of primate reactivity based coronary vasospasm. Am J Physiol 272:H2645-H2654
22. Yu JG, O'Brien WE, Lee TJ 1997 Morphologic evidence for L-citrulline conversion to L-arginine via the argininosuccinate pathway in porcine cerebral perivascular nerves. J Cereb Blood Flow Metab 17:884-893
23. Press MF, Greene GL 1988 Localization of progesterone receptor with monoclonal antibodies to the human progestin receptor. Endocrinology 122:1165-1175
24. 2 receptor protein. J Biol Chem 277:16791-16797
25. Bentel JM, Birrell SN, Pickering MA, Holds DJ, Horsfall DJ, Tilley WD 1999 Androgen receptor agonist activity of the synthetic progestin, medroxyprogesterone acetate, in human breast cancer cells. Mol Cell Endocrinol 154:11-20
26. Sitruk-Ware R 2000 Progestins and cardiovascular risk markers. Steroids 65:651-658
27. Fujimoto R, Morimoto I, Morita E, Sugimoto H, Ito Y, Eto S 1994 Androgen receptors, 5α-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells. J Steroid Biochem Mol Biol 50:169-174
28. 2 receptors in rat aortic smooth-muscle cells. J Cardiovasc Pharmacol 29:311-315
29. Lin AL, Gonzalez Jr R, Carey KD, Shain SA 1987 Gender and baboon aortic steroid hormone receptors. Arteriosclerosis 7:248-255
30. Williams JK, Honore EK, Washburn SA, Clarkson TB 1994 Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys. J Am Coll Cardiol 24:1757-1761
31. Rosano GM, Webb CM, Chierchia S, Morgani GL, Gabraele M, Sarrel PM, de Ziegler D, Collins P 2000 Natural progesterone, but not medroxyprogesterone acetate, enhances the beneficial effect of estrogen on exercise-induced myocardial ischemia in postmenopausal women. J Am Coll Cardiol 36:2154-2159
32. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E 1998 Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) research group. JAMA 280:605-613
33. Uruno A, Sugawara A, Kudo M, Sato M, Sato K, Ito S, Takeuchi K 2003 Transcription suppression of thromboxane receptor gene expression by retinoids in vascular smooth muscle cells. Hypertens Res 26:815-821
34. 2 biosynthesis in atherosclerosis. Proc Natl Acad Sci USA 85:4511-4515
35. 2, and hypertension. Clin Invest Med 13:343-352
36. Traupe T, Lang M, Goettsch W, Munter K, Morawietz H, Vetter W, Barton M 2002 Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression. J Hypertens 20:2239-2245
37. 1 receptor antagonist losartan. Br J Pharmacol 134:1385-1392
38. Mercuro G, Zoncu S, Dragoni F 2003 Gender differences in cardiovascular risk factors. Ital Heart J 4:363-366
39. Barrett-Connor E 2003 Clinical review 162: cardiovascular endocrinology 3: an epidemiologist looks at hormones and heart disease in women. J Clin Endocrinol Metab 88:4031-4042
40. Muller M, van der Schouw YT, Thijssen JH, Grobbee DE 2003 Endogenous sex hormones and cardiovascular disease in men. J Clin Endocrinol Metab 88:5076-5086
41. Channer KS, Jones TH 2003 Cardiovascular effects of testosterone: implications of the "male menopause?" Heart 89:121-122
42. Ong PJ, Patrizi G, Chong WC, Webb CM, Hayward CS, Collins P 2000 Testosterone enhances flow-mediated brachial artery reactivity in men with coronary artery disease. Am J Cardiol 85:269-272
43. Webb CM, McNeill JG, Hayward CS, de Zeigler D, Collins P 1999 Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 100:1690-1696
44. Rosano GM, Leonardo F, Pagnotta P, Pelliccia F, Panina G, Cerquetani E, della Monica PL, Bonfigli B, Volpe M, Chierchia SL 1999 Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99:1666-1670
45. English KM, Steeds RP, Jones TH, Diver MJ, Channer KS 2000 Low-dose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: a randomized, double-blind, placebo-controlled study. Circulation 102:1906-1911
46. Liu PY, Death AK, Handelsman DJ 2003 Androgens and cardiovascular disease. Endocr Rev 24:313-340
47. Sarrel PM 1997 Clinical findings related to arterial effects of ovarian steroids. In: Forte TM, ed. Hormonal metabolic and cellular influences on cardiovascular disease in women. American Heart Association Monograph Series. Malden, MA: Blackwell Futura; 325-338
48. Reckelhoff JF, Zhang H, Srivastava K, Granger JP 1999 Gender differences in hypertension in spontaneously hypertensive rats: role of androgens and androgen receptor. Hypertension 34:920-923
49. 2 mimetic induced coronary artery vasoconstriction in guinea pigs. Eur J Clin Invest 24(Suppl 1):50-52
50. 2 receptor expression in human erythroleukemia cells. Am J Physiol 265:E928-E934
51. 2 receptors. Agents Actions 45(Suppl):19-26
52. Sorensen MB, Collins P, Ong PJ, Webb CM, Hayward CS, Asbury EA, Gatehouse PD, Elkington AG, Yang GZ, Kubba A, Pennell DJ 2002 Longterm use of contraceptive depot medroxyprogesterone acetate in young women impairs arterial endothelial function assessed by cardiovascular magnetic resonance. Circulation 106:1646-1651
53. Minshall RD, Pavcnik D, Browne DL, Hermsmeyer RK 2002 Nongenomic vasodilator action of progesterone on primate coronary arteries. J Appl Physiol 92:701-708
54. Stanczyk FZ 2003 All progestins are not created equal. Steroids 68:879-890
55. Wiegratz I, Kuhl H 2004 Progestogen therapies: differences in clinical effects? Trends Endocrinol Metab 15:277-285