Transcription suppression of thromboxane receptor gene expression by retinoids in vascular smooth muscle cells

Hypertension Research

Volumn 26, Issue 10, 2003, Pages 815-821

  Uruno, Akira ^b   Sugawara, Akira ^b   Kudo, Masataka ^b   Sato, Mayumi ^a   Sato, Kazunori ^b   Ito, Sadayoshi ^b   Takeuchi, Kazuhisa ^b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

9 cis retinoic acid; All trans retinoic acid; Retinoic acid receptor; Retinoid; Retinoid X receptor

Indexed keywords

ALITRETINOIN; MESSENGER RNA; RECEPTOR BLOCKING AGENT; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; THROMBOXANE; THROMBOXANE RECEPTOR; THYMIDINE; TRITIUM;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; COMPLEX FORMATION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MECHANISM; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; NONHUMAN; PROMOTER REGION; RAT; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELLS, CULTURED; MUSCLE, SMOOTH, VASCULAR; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, RETINOIC ACID; RECEPTORS, THROMBOXANE; RESPONSE ELEMENTS; RNA, MESSENGER; SP1 TRANSCRIPTION FACTOR; THROMBOXANE A2; THYMIDINE; TRANSCRIPTION, GENETIC; TRANSFECTION; TRETINOIN; TRITIUM;

EID: 0242441549     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.26.815     Document Type: Article

References (33)

1. Pakala R, Willerson JT, Benedict CR: Effect of serotonin, thromboxane A2, and specific receptor antagonists on vascular smooth muscle cell proliferation. Circulation 1997; 96: 2280-2286.
2. Ali S, Davis MG, Becker MW, Dorn GW 2nd: Thromboxane A2 stimulates vascular smooth muscle hypertrophy by up-regulating the synthesis and release of endogenous basic fibroblast growth factor. J Biol Chem 1993; 268.: 17397-17403.
3. Mehta JL, Lawson D, Mehta P, Saldeen T: Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis. Proc Natl Acad Sci USA 1988; 85: 4511-4515.
4. Cheng Y, Austin SC, Rocca B, et al: Role of prostacyclin in the cardiovascular response to thromboxane A2. Science 2002; 296: 539-541.
5. Takahashi N, Takeuchi K, Sugawara A, et al: Structure and transcriptional function of the 5′-flanking region of rat thromboxane receptor gene. Biochem Biophys Res Commun 1998; 244: 489-493.
6. Sugawara A, Takeuchi K, Uruno A, et al: Differential effects among thiazolidinediones on the transcription of thromboxane receptor and angiotensin II type 1 receptor genes. Hypertens Res 2001; 24: 229-233.
7. Sugawara A, Uruno A, Kudo M, et al: Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells. J Biol Chem 2002; 277: 9676-9683.
8. Miano JM, Berk BC: Retinoids: new insight into smooth muscle cell growth inhibition. Arterioscler Thromb Vasc Biol 2001; 21: 724-726.
9. Miano JM, Berk BC: Retinoids: versatile biological response modifiers of vascular smooth muscle phenotype. Circ Res 2000; 87: 355-362.
10. Allenby G, Bocquel MT, Saunders M, et al: Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 1993; 90: 30-34.
11. Umesono K, Murakami KK, Thompson CC, Evans RM: Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 1991; 65: 1255-1266.
12. Kobayashi A, Sogawa K, Fujii-Kuriyama Y: Cooperative interaction between AhR.Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. J Biol Chem 1996; 271: 12310-12316.
13. Sugawara A, Yen PM, Qi Y, Lechan RM, Chin WW: Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology 1995; 136: 1766-1774.
14. Kagechika H: Novel synthetic retinoids and separation of the pleiotropic retinoidal activities. Curr Med Chem 2002; 9: 591-608.
15. Suzuki T, Moriya T, Sugawara A, Ariga N, Takabayashi H, Sasano H: Retinoid receptors in human breast carcinoma: possible modulators of in situ estrogen metabolism. Breast Cancer Res Treat 2001; 65: 31-40.
16. Miano JM, Topouzis S, Majesky MW, Olson EN: Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation 1996; 93: 1886-1895.
17. Black AR, Black JD, Azizkhan-Clifford J: Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 2001; 188: 143-160.
18. Suzuki Y, Shimada J, Shudo K, Matsumura M, Crippa MP, Kojima S: Physical interaction between retinoic acid receptor and Sp1: mechanism for induction of urokinase by retinoic acid. Blood 1999; 93: 4264-4276.
19. Husmann M, Dragneva Y, Romahn E, Jehnichen P: Nuclear receptors modulate the interaction of Sp1 and GC-rich DNA via ternary complex formation. Biochem J 2000; 352: 763-772.
20. Shimada J, Suzuki Y, Kim SJ, Wang PC, Matsumura M, Kojima S: Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif. Mol Endocrinol 200 1; 15: 1677-1692.
21. Schule R, Rangarajan P, Yang N, et al: Retinoic acid is a negative regulator of AP-1-responsive genes. Proc Natl Acad Sci USA 1991; 88: 6092-6096.
22. Wakino S, Kintscher U, Kim S, et al: Retinoids inhibit proliferation of human coronary smooth muscle cells by modulating cell cycle regulators. Arterioscler Thromb Vasc Biol 2001; 21:746-751.
23. Kosaka C, Sasaguri T, Komiyama Y, Takahashi H: All-trans retinoic acid inhibits vascular smooth muscle cell proliferation targeting multiple genes for cyclins and cyclin-dependent kinases. Hypertens Res 2001; 24: 579-588.
24. Takeda K, Ichiki T, Funakoshi Y, Ito K, Takeshita A: Downregulation of angiotensin II type 1 receptor by all-trans retinoic acid in vascular smooth muscle cells. Hypertension 2000; 35: 297-302.
25. Haxsen V, Adam-Stitah S, Ritz E, Wagner J: Retinoids inhibit the actions of angiotensin II on vascular smooth muscle cells. Circ Res 2001; 88: 637-644.
26. Ou H, Haendeler J, Aebly MR, et al: Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. Circ Res 2000; 87: 881-887.
27. Leville CD, Osipov VO, Jean-Claude JM, Seabrook GR, Towne JB, Cambria RA: All-trans-retinoic acid decreases cell proliferation and increases apoptosis in an animal model of vein bypass grafting. Surgery 2000; 128: 178-184.
28. Blank RS, Swartz EA, Thompson MM, Olson EN, Owens GK: A retinoic acid-induced clonal cell line derived from multipotential P19 embryonal carcinoma cells expresses smooth muscle characteristics. Circ Res 1995; 76: 742-749.
29. Suzuki T, Kim HS, Kurabayashi M, et al: Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells: use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2. Circ Res 1996; 78: 395-404.
30. Kato S, Sasaguri Y, Morimatsu M: Down-regulation in the production of matrix metalloproteinase 1 by human aortic intimal smooth muscle cells. Biochem Mol Biol Int 1993; 31: 239-248.
31. Axel DI, Frigge A, Dittmann J, et al: All-trans retinoic acid regulates proliferation, migration, differentiation, and extra-cellular matrix turnover of human arterial smooth muscle cells. Cardiovasc Res 2001; 49: 851-862.
32. Miano JM, Kelly LA, Artacho CA, Nuckolls TA, Piantedosi R, Blaner WS: All-trans-retinoic acid reduces neointimal formation and promotes favorable geometric remodeling of the rat carotid artery after balloon withdrawal injury. Circulation 1998; 98: 1219-1227.
33. Neuville P, Yan Z, Gidlof A, et al: Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARalpha-dependent signaling pathway. Arterioscler Thromb Vasc Biol 1999; 19:1 430-1436.