Molecular characterization of two anthranilate synthase alpha subunit genes in Camptotheca acuminata

Planta

Volumn 221, Issue 3, 2005, Pages 352-360

  Lu, Hua ^a   Gorman, Elizabeth ^b   McKnight, Thomas D ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

Author keywords

Camptothecin; Early indole pathway; Indole alkaloids; Secondary metabolism; Tryptophan; Vascular tissue

Indexed keywords

BIOLOGICAL ORGANS; BIOSYNTHESIS; ENZYMES; GENES; METABOLISM; TISSUE; TOBACCO;

ANTICANCER COMPOUNDS; ANTIVIRAL COMPOUND; CAMPTOTHECIN (CPT); MONOTERPENE INDOLE ALKALOIDS (MIA); TRYPTOPHAN SYNTHASE;

PLANTS (BOTANY);

ANTHRANILATE SYNTHASE; BETA GLUCURONIDASE; COMPLEMENTARY DNA; HYBRID PROTEIN; ISOENZYME; MESSENGER RNA; PLANT DNA;

ARTICLE; CAMPTOTHECA; CHEMISTRY; DNA SEQUENCE; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLANT; PLANT SEED; PROMOTER REGION; TOBACCO; TRANSGENIC PLANT; WESTERN BLOTTING;

ANTHRANILATE SYNTHASE; BLOTTING, WESTERN; CAMPTOTHECA; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DNA, PLANT; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, PLANT; GLUCURONIDASE; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MOLECULAR SEQUENCE DATA; PLANT SHOOTS; PLANTS, GENETICALLY MODIFIED; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SEEDS; SEQUENCE ANALYSIS, DNA; TOBACCO;

BIOSYNTHESIS; ENZYMES; GENES; METABOLISM; PLANTS; TISSUE; TOBACCO;

CAMPTOTHECA; CAMPTOTHECA ACUMINATA; NICOTIANA OBTUSIFOLIA; NICOTIANA TABACUM;

EID: 21144454580     PISSN: 00320935     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00425-004-1450-z     Document Type: Article

References (35)

1. Berlyn MB, Last RL, Fink GR (1989) A gene encoding the tryptophan synthase beta subunit of Arabidopsis thaliana. Proc Natl Acad Sci USA 86:4604-4608
2. Bohlmann J, DeLuca V, Eilert U, Martin W (1995) Purification and cDNA cloning of anthranilate synthase from Ruta graveolens: modes of expression and properties of native and recombinant enzymes. Plant J 7:491-501
3. Bohlmann J, Lins T, Martin W, Eilert U (1996) Anthranilate synthase from Ruta graveolens. Duplicated AS alpha genes encode tryptophan-sensitive and tryptophan-insensitive isoenzymes specific to amino acid and alkaloid biosynthesis. Plant Physiol 111:507-514
4. Crawford IP (1989) Evolution of a biosynthetic pathway: the tryptophan paradigm. Annu Rev Microbiol 43:567-600
5. Facchini PJ, Park SU (2003) Developmental and inducible accumulation of gene transcripts involved in alkaloid biosynthesis in opium poppy. Phytochemistry 64:177-186
6. Herrmann KM, Weaver LM (1999) The shikimate pathway. Annu Rev Plant Physiol Plant Mol Biol 50:473-503
7. Hutchinson CR, Heckendorf AH, Daddona PE, Hagaman E, Wenkert E (1974) Biosynthesis of camptothecin. I. Definition of the overall pathway assisted by carbon-13 nuclear magnetic resonance analysis. J Am Chem Soc 96:5609-5611
8. Knaggs AR (2003) The biosynthesis of shikimate metabolites. Nat Prod Rep 20:119-136
9. Kreps JA, Ponappa T, Dong W, Town CD (1996) Molecular basis of alpha-methyltryptophan resistance in amt-1, a mutant of Arabidopsis thaliana with altered tryptophan metabolism. Plant Physiol 110:1159-1165
10. Kutchan TM (1993) Strictosidine: from alkaloid to enzyme to gene. Phytochemistry 32:493-506
11. Li J, Last RL (1996) The Arabidopsis thaliana trp5 mutant has a feedback-resistant anthranilate synthase and elevated soluble tryptophan. Plant Physiol 110(1):51-59
12. Li J, Chen S, Zhu L, Last RL (1995a) Isolation of cDNAs encoding the tryptophan pathway enzyme indole-3-glycerol phosphate synthase from Arabidopsis thaliana. Plant Physiol 108:877-878
13. Li J, Zhao J, Rose AB, Schmidt R, Last RL (1995b) Arabidopsis phosphoribosylanthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes. Plant Cell 7:447-461
14. López-Meyer M, Nessler CL (1997) Tryptophan decarboxylase is encoded by two autonomously regulated genes in Camptotheca acuminata which are differentially expressed during development and stress. Plant J 11:1167-1175
15. López-Meyer M, Nessler CL, McKnight TD (1994) Sites of accumulation of the antitumor alkaloid camptothecin in Camptotheca acuminata. Planta Med 60:558-560
16. Lorence L, Nessler CL (2004) Camptothecin, over four decades of surprising findings. Phytochemistry 65:2735-2749
17. Lowry O, Rosebrough N, Farr A, Randall R (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193:265-275
18. Lu H, McKnight TD (1999) Tissue-specific expression of the beta-subunit of tryptophan synthase in Camptotheca acuminata, an indole alkaloid-producing plant. Plant Physiol 120:43-52
19. Matsuo H, Taniguchi K, Hiramoto T, Yamada T, Ichinose Y, Toyoda K, Takeda K, Shiraishi T (2001) Gramine increase associated with rapid and transient systemic resistance in barley seedlings induced by mechanical and biological stresses. Plant Cell Physiol 42:1103-1111
20. McKnight TD, Bergey DR, Burnett RJ, Nessler CL (1991) Expression of enzymatically active and correctly targeted strictosidine synthase in transgenic tobacco plants. Planta (Heidelberg) 185:148-152
21. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue culture. Physiol Plant 15:473-497
22. Nagao RT, Shah DM, Eckenrode VK, Meagher RB (1981) Multigene family of actin-related sequences isolated from a soybean genomic library. DNA 1:1-9
23. Niyogi KK, Fink GR (1992) Two anthranilate synthase genes in Arabidopsis: defense-related regulation of the tryptophan pathway. Plant Cell 4:721-733
24. Oberlies NH, Kroll DJ (2004) Camptothecin and taxol: historic achievements in natural products research. J Nat Prod 67:129-135
25. Radwanski ER, Zhao J, Last RL (1995) Arabidopsis thaliana tryptophan synthase alpha: gene cloning, expression, and subunit interaction. Mol Gen Genet 248:657-667
26. Rothenberg ML (1997) Topoisomerase I inhibitors: review and update. Ann Oncol 8:837-855
27. Soepenberg O, Sparreboom A, Verweij J (2003) Clinical studies of camptothecin and derivatives. Alkaloids Chem Biol 60:1-50
28. Song HS, Brotherton JE, Gonzales RA, Widholm JM (1998) Tissue culture-specific expression of a naturally occurring tobacco feedback-insensitive anthranilate synthase. Plant Physiol 117:533-543
29. Tozawa Y, Hasegawa H, Terakawa T, Wakasa K (2001) Characterization of rice anthranilate synthase alpha-subunit genes OASA1 and OASA2. Tryptophan accumulation in transgenic rice expressing a feedback-insensitive mutant of OASA1. Plant Physiol 126:1493-1506
30. Vazquez-Flota FA, St-Pierre B, De Luca V (2000) Light activation of vindoline biosynthesis does not require cytomorphogenesis in Catharanthus roseus seedlings. Phytochemistry 55:531-536
31. Vidensek N, Lim P, Campbell A, Carlson C (1990) Taxol content in bark, wood, root, leaf, twig, and seedling from several Taxus species. J Nat Prod 53:1609-1610
32. Wall ME (1998) Camptothecin and taxol: discovery to clinic. Med Res Rev 18:299-314
33. Yamazaki Y, Sudo H, Yamazaki M, Aimi N, Saito K (2003) Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds. Plant Cell Physiol 44:395-403
34. Zhao J, Last RL (1995) Immunological characterization and chloroplast localization of the tryptophan biosynthetic enzymes of the flowering plant Arabidopsis thaliana. J Biol Chem 270:6081-6087
35. Zhou X, Wang W, Hu T (1992) Determination of total alkaloid in seedling bulbs of Fritillaria thunbergii Miq. Zhongguo Zhong Yao Za Zhi 17:270-272, 320