Biphasic accumulation kinetics of [99mTc]-hexakis-2- methoxyisobutyl isonitrile in tumour cells and its modulation by lipophilic P-glycoprotein ligands

European Journal of Pharmaceutical Sciences

Volumn 25, Issue 2-3, 2005, Pages 201-209

  Márián, Teréz ^a   Balkay, László ^a   Szabó, Gábor ^a   Krasznai, Zoárd T ^a   Hernádi, Zoltán ^a   Galuska, László ^a   Szabó Péli, Judit ^a   Ésik, Olga ^b   Trón, Lajos ^a   Krasznai, Zoltán ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF PÉCS   (Hungary)

Author keywords

18FDG; Biphasic 99mTc MIBI uptake; Lipophilic ligand; Multidrug resistance; Rhodamine 123

Indexed keywords

CYCLOSPORIN A; FLUORODEOXYGLUCOSE F 18; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; RHODAMINE 123; VERAPAMIL;

ACIDIFICATION; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG UPTAKE; HUMAN; HUMAN CELL; INCUBATION TIME; LIPOPHILICITY; MEMBRANE FLUIDITY; PRIORITY JOURNAL; TUMOR CELL;

ANIMALS; CELL LINE, TUMOR; CRICETINAE; CYCLOSPORINE; DRUG RESISTANCE, MULTIPLE; FLUORINE RADIOISOTOPES; GLUCONATES; HUMANS; INTRACELLULAR MEMBRANES; LIGANDS; MEMBRANE FLUIDITY; MEMBRANE POTENTIALS; MICE; MITOCHONDRIA; P-GLYCOPROTEIN; PERMEABILITY; RHODAMINE 123; TECHNETIUM TC 99M SESTAMIBI; VERAPAMIL;

EID: 21144454228     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2005.02.010     Document Type: Article

References (36)

1. H. Akaike A new look at the statistical model identification IEEE Tra. Aut. Contr. 19 1974 716 723
2. S.A. Arbab, K. Koizumi, K. Toyama, and T. Araki Uptake of technetium-99m-tetrofosmin, technetium-99m-MIBI and thallium-201 in tumor cell lines J. Nucl. Med. 37 1996 1551 1556
3. 99m-tetrofosmin in tumor cells Nucl. Med. Commun. 24 2003 155 166
4. i of transformed cells J. Photochem. Photobiol. B: Biol. 16 1992 367 375
5. 99mTc-MIBI Nucl. Med. Biol. 22 1995 585 588
6. H.J. Broxterman, H.M. Pinedo, G.J. Schuurhuis, and J. Lankelma Cyclosporin A and verapamil have different effects on energy metabolism in multidrug-resistant tumour cells Br. J. Cancer 62 1990 85 88
7. 99mTc-MIBI imaging as a predictor of therapy response in osteosarcoma compared with multidrug resistance-associated protein and P-glycoprotein expression J. Nucl. Med. 44 2003 1394 1401
8. M. Castaing, A. Loiseau, and L. Djoudi Effects of cholesterol on dye leakage induced by multidrug-resistance modulators from anionic liposomes Eur. J. Pharm. Sci. 18 2003 81 88
9. 3H-daunomycin uptake in human carcinoma cells: relation to the MDR phenotype and effects of reversing agents J. Nucl. Med. 40 1999 672 676
10. W.S. Chen, K.E. Luker, J.L. Dahlheimer, C.M. Pica, G.D. Luker, and D. Piwnica-Worms Effects of MDR1 And MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on the transport of (99m)Tc-tetrofosmin Biochem. Pharmacol. 60 2000 413 426
11. 99mTc-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma Eur. J. Nucl. Med. Mol. Imaging 30 2003 879 887
12. D.G. Eytan, R. Regev, G. Oren, and Y.G. Assaraf The role of passive transbilayer drug movement in multidrug resistance and its modulation J. Biol. Chem. 271 1996 12897 12902
13. K. Goda, L. Balkay, T. Márián, L. Trón, A. Aszalós, and G. Szabó Jr. Intracellular pH does not affect drug extrusion by P-glycoprotein J. Photochem. Photobiol. B: Biol. 34 1996 177 182
14. K. Hamacher, H.H. Coenen, and G. Stöcklin Efficient stereospecific synthesis of no-carrier-added 2-(18F)-fluoro-2-deoxy-d-glucose using aminopolyether supported nucleophilic substitution J. Nucl. Med. 27 1986 235 238
15. L.V. Johnson, M.L. Wals, and L.B. Chen Localization of mitochondria in living cells with rhodamine 123 Proc. Natl. Acad. Sci. U.S.A. 77 1980 990 994
16. 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function Eur. J. Nucl. Med. Mol. Imaging 30 2003 1529 1531
17. L. Kostakoglu, P. Kiratli, S. Ruacan, M. Hayran, S. Emri, E.L. Ergün, and C.F. Bekdik Association of tumor washout rates and accumulation of technetium-99m-MIBI with expression of P-glycoprotein in lung cancer J. Nucl. Med. 39 1998 228 234
18. R. Krishna, and L.D. Mayer Multidrug resistance (MDR) in cancer. Mechanism, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs Eur. J. Pharm. Sci. 11 2000 265 283
19. P. Lu, R. Liu, and F.J. Sharom Drug transport by reconstituted P-glycoprotein in proteoliposomes. Effect of substrates and modulators, and dependence on bilayer phase state Eur. J. Biochem. 268 2001 1687 1697
20. D.A. Mankoff, and J.R. Bellon Positron-emission tomographic imaging of cancer: glucose metabolism and beyond Semin. Radiat. Oncol. 11 2001 16 27
21. T. Márián, G. Szabó, K. Goda, H. Nagy, N. Szincsák, I. Juhász, L. Galuska, L. Balkay, P. Mikecz, L. Trón, and Z. Krasznai In vivo and in vitro multitracer analyses of P-glycoprotein expression related multidrug resistance Eur. J. Nucl. Med. Mol. Imaging 30 2003 1147 1154
22. E.B. Mechetner, and I.B. Roninson Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody Proc. Natl. Acad. Sci. U.S.A. 89 1992 5824 5828
23. H. Motulsky, and A. Christopoulos Fitting Models to Biological Data Using Linear and Nonlinear Regression: A Practical Guide to Curve Fitting 2004 Oxford University Press
24. I. Pajeva, D.K. Todorov, and J. Seydel Membrane effects of the antitumor drugs doxorubicin and thaliblastine: comparison to multidrug resistance modulators verapamil and trans-flupentixol Eur. J. Pharmaceut. Sci. 21 2004 243 250
25. E.K.J. Pauwels, V.R. McCready, J.H.M.B. Stoot, and D.F.P. van Deurzen The mechanism of accumulation of tumour-localising radiopharmaceuticals Eur. J. Nucl. Med. 25 1998 277 305
26. N. Perek, D. Denoyer, F. Dubois, and F. Koumanov Malignant gliomas display altered plasma membrane potential and pH regulation - interaction with Tc-99m-MIBI and Tc-99m-Tetrofosmin uptakes Gen. Physiol. Biophys. 21 2002 381 404
27. D. Piwnica-Worms, J.F. Kronauge, and M.L. Chiu Uptake and retention of hexakis (2-methoxy isobutyl isonitrile) technetium(I) in cultured chick myocardial cells Circulation 82 1990 1826 1838
28. D. Piwnica-Worms, V.V. Rao, J.F. Kronauge, and J.M. Croop Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation Biochemistry 34 1995 12210 12220
29. 99mTc-tetrofosmin in human breast cancer and soft tissue sarcoma cell lines Nucl. Med. Commun. 22 2001 645 650
30. R.C. Scaduto, and L. Grotyohann Measurement of mitochondrial membrane potential using fluorescent rhodamin derivatives Biophys. J. 76 1999 469 477
31. H. Schuldes, J. Dolderes, J. Knobloch, S. Bade, R. Bickeboller, B.G. Woodcock, D. Jonas, and G. Zimmer Relationship between plasma membrane fluidity and R-verapamil action in CHO cells Int. J. Clin. Pharmacol. Ther. 36 1998 71 73
32. R.G. Stern, B.N. Milestone, and R.A. Gatenby Carcinogenesis and plasma membrane Med. Hypotheses 52 1999 367 372
33. 2+ antagonists on multidrug resistance MDR1-mediated transport and MDR1 mRNS expression Eur. J. Pharm. Sci. 16 2002 159 165
34. L. Trón, J.P. Siegel, and A. Aszalós Effect of cyclosporine A on the intracellular pH of lymphocytes as measured by flow cytometry Biochem. Med. Metab. Biol. 41 1989 164 170
35. K. Utsunomiya, J.R. Ballinger, M. Piquette-Miller, A.M. Rauth, W. Tang, Z. Su, and M. Ichise Comparison of the accumulation and efflux kinetics of technecium-99m sestamibi and technetium-99m tetrofosmin in an MRP-expressing tumour cell line Eur. J. Nucl. Med. 27 2000 1786 1792
36. L.R. Wahl Targeting glucose transporters for tumor imaging: "Sweet" idea "Sour" result J. Nucl. Med. 37 1996 1038 1041