Intracellular pH does not affect drug extrusion by P-glycoprotein

Journal of Photochemistry and Photobiology B: Biology

Volumn 34, Issue 2-3, 1996, Pages 177-182

  Goda, Katalin ^a   Balkay, László ^a   Márián, Teréz ^a   Trón, Lajos ^a   Aszalós, Adorján ^b   Szabó Jr , Gábor ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Intracellular pH; Multidrug resistance; P glycoprotein

Indexed keywords

CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CARRIER PROTEIN; DAUNORUBICIN; GLYCOPROTEIN P; IONOPHORE; VERAPAMIL;

ALKALINITY; ARTICLE; CELL PH; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG TRANSPORT; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; RADIOACTIVITY;

EID: 0030199801     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/1011-1344(95)07282-9     Document Type: Article

References (38)

1. [1] J.A. Endicott and V. Ling, The biochemistry of P-glycoprotein-mediated multidrug resistance, Ann. Rev. Biochem., 58 (1989) 137-171.
2. [2] M.M. Gottesman and I. Pastan, Biochemistry of multidrug resistance mediated by the multidrug transporter, Ann. Rev. Biochem., 62 (1993) 385-427.
3. [3] K. Danø, Active outward transport of daunomycin in Erlich ascites tumor cells, Biochim. Biophys. Acta, 455 (1973) 152-162.
4. [4] C.F. Higgins, ABC transporters: from microorganisms to man, Ann. Rev. Cell Biol., 8 (1992) 67-113.
5. [5] C.A. Doige and G. Ferro-Luzzi Ames, ATP-dependent transport systems in bacteria and humans: relevance to cystic fibrosis and multidrug resistance, Ann. Rev. Microbiol., 47 (1993) 291-319.
6. [6] R.C. Sharma, S. Inoue, J. Roitelman, R.T. Schimke and R.D. Simoni, Peptide transport by the multidrug resistance pump, J. Biol. Chem., 267 (1991) 5731-51734.
7. [7] M.M. Cornwell, I. Pastan and M.M. Gottesman, Certain calcium channel blockers bind specifically to multidrug resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein, J. Biol. Chem. 262 (1987) 2166-2170.
8. [8] J.M. Zamora and W.T. Beck, Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukaemic cells, Biochem. Pharmacol., 35 (1986) 4303-4310.
9. [9] J.L. Weaver, G. Szabó Jr., M.M. Gottesman, S. Goldenberg and A. Aszalos, The effect of ion channel blockers, immunosuppressive agents, and other drugs on the activity of the multi-drug transporter, Int. J. Cancer, 54 (1993) 1-6.
10. [10] D.R. Ferry, M.A. Russel and M.H. Cullen, P-glycoprotein possesses a 1,4-dihydropyridine-selective drug acceptor site which is allosterically coupled to a vinca-alkaloid-selective binding site, Biochem. Biophys. Res. Commun., 188 (1992) 440-445.
11. [11] W.T. Beck, The cell biology of multiple drug resistance, Biochem. Pharmacol., 36 (1987) 2879-2887.
12. [12] T. Skovsgaard, Transport and binding of daunorubicin, adriamycin, and rubidazone in Ehrlich ascites tumor cells, Biochem. Pharmacol., 26 (1977) 215-222.
13. [13] T.D. Madden, P.R. Harrigan, L.C.L. Tai, M.B. Bally, L.D. Mayer, T.E. Redelmeir, H.C. Loughrey, C.P.S. Tilcock, L.W. Reinish and P.R. Cullis, The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey, Chem. Phys. Lipids, 53 (1990) 37-46.
14. [14] L.D. Mayer, M.B. Bally and P.R. Cuilis, Uptake of adriamycin into large unilamellar vesicles in response to a pH gradient, Biochem. Biophys. Acta, 857 (1986) 123-126.
15. [15] R.C. Lyon, J.S. Cohen, P.J. Faustino, F. Megnin and C.E. Myers, Glucose metabolism in drug-sensitive and drug-resistant human breast cancer cells monitored by magnetic resonance spectroscopy, Cancer Res., 48 (1988) 870-877.
16. [16] H.G. Keizer and H. Joenje, Increased cytosolic pH in multidrug-resistant human lung tumor cells: effect of verapamil, J. Natl. Cancer Inst., 81 (1989) 706-709.
17. [17] D. Boscoboinik, R.S. Gupta and R.M. Epand, Investigation of the relationship between altered intracellular pH and multidrug resistance in mammalian cells, Br. J. Cancer, 61 (1990) 568-572.
18. [18] F. Thiebaut, S.J. Currier, J. Whitaker, R.P. Haugland, M.M. Gottesman, I. Pastan and M.C. Wellingham, Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye, J. Histochem. Cytochem., 38 (1990) 685-690.
19. [19] S. Simon, D. Roy and M. Schindler, Intracellular pH and the control of multidrug resistance, Proc. Natl. Acad. Sci. USA, 91 (1994) 1128-1132.
20. i homeostasis in multidrug-resistant (MDR) cells: further characterization of a series of MDR cell lines expressing different levels of P-glycoprotein, Biochemistry, 32 (1993) 11 042-11 056.
21. [21] G.A. Altenberg, G. Young, J.K. Horton, D. Glass, J.A. Belli and L. Reuss, Changes in intra-or extracellular pH do not mediate P-glycoprotein-dependent multidrug resistance, Proc. Natl. Acad. Sci. USA, 90 (1993) 9735-9738.
22. [22] I. Calendi, A. di Marco, B. Regiani, B. Scarpinato and E. Valentini, On physico-chemical interactions between daunomycin and nucleic acids, Biochem. Biophys. Acta, 103 (1965) 25-49.
23. AD cells and its relation to cellular drug localisation, Biochim. Biophy. Acta, 1093 (1991) 147-152.
24. - exchange in chinese hamster ovary cells, Biochemistry, 33 (1994) 7239-7249.
25. [25] J. Kasianowicz, R. Benz and S. Mclaughlin, The kinetic mechanism by which CCCP (carbonyl cyanide m-chlorophenylhydrazone) transports protons across membranes, J. Membr. Biol., 82 (1984) 179-190.
26. [26] D.-W. Shen, C. Cardarelli, J. Hwang, M.M. Cornwell, N. Richert, S. Ishii, I. Pastan and M.M. Gottesman, Multiple drug-resistant human KB carcinoma cells independently selected for high level resistance to colhicine, adriamycine or vinblastine show changes in expression of specific proteins, J. Biol. Chem., 261 (1986) 7762-7770.
27. [27] K.G. Louie, T.C. Hamilon, M.A. Winkler, B.C. Behrens, T. Tsuruo, R.W. Klecker, W.M. Mchoy, K.R. Grotzinger, C.E. Meyers, R.C. Young and R.F. Ozols, Adriamycin accumulation and metabolism in adriamycin-sensitive and resistant human ovarian cancer cell lines, Biochem. Pharmacol., 35 (1986) 467-472.
28. [28] A. Krishan, Rapid flow cytophotometric analysis of mammalian cell cycle by propidium iodide staining, J. Cell Biol., 66 (1975) 188-192.
29. [29] J. Lankelma, E. Laurensse and H.M. Pinedo, A flow-through tissue culture system with fast dynamic response, Anal. Biochem., 127 (1982) 340-345.
30. [30] S. Grinstein, S. Cohen and A. Rothstein, Cytoplasmic pH regulation in thymic lymphocytes by an amiloride-sensitive Na/H antiport, J. Gen. Physiol., 83 (1984) 341-370.
31. i of transformed cells, J. Photochem. Photobiol B: Biol., 16 (1992) 367-375.
32. [32] L. Homolya, Zs. Holló, U.A. Germann, I. Pastan, M.M. Gottesman and B. Sarkadi, Fluorescent cellular indicators are extruded by the multidrug resistance protein, J. Biol. Chem., 268 (1993) 21 493-21 496.
33. [33] A.L. Hodgkin, The ionic basis of electrical activity in nerve and muscle, Biol. Rev., 26 (1951) 339-409.
34. [34] E.G. Spoelstra, H.V, Westerhoff, H. Dekker and J. Lankelma, Kinetics of daunorubicine transport by P-glycoprotein of intact cancer cells, Eur. J. Biochem., 207 (1992) 567-579.
35. [35] F. Frezard and A. Garnier-Suillerot, Comparison of the membrane transport of antracycline derivatives in drug-resistant and drug-sensitive K562 cells, Eur. J. Biochem., 196 (1991) 483-491.
36. [36] S. Ohkuma and B. Poole, Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents, Proc. Natl. Acad. Sci., 75 (1978) 3327-3331.
37. [37] E.J.F. Demant, M. Sehested and P.B. Jensen, A model for computer simulation of P-glycoprotein and transmembrane ΔpH-mediated antracycline transport in multidrug-resistant tumor cells, Biochim. Biophys. Acta, 1055 (1990) 117-125.
38. [39] H.J. Broxterman, H.M. Pinedo, C.M. Kuiper, G.J. Schuurhuis and J. Lankelma, Glycolysis in P-glycoprotein-overexpressing human tumor cell lines. Effect of resistance-modifying agents, FEBS Lett., 247 (1989) 405-410.