Relationship between plasma membrane fluidity and R-verapamil action in CHO cells

International Journal of Clinical Pharmacology and Therapeutics

Volumn 36, Issue 2, 1998, Pages 71-73

  Schuldes, H ^a,b   Dolderer, J ^a   Knobloch, J ^a   Bade, S ^a   Bickeboller R ^a   Woodcock, B G ^a   Jonas, D ^a   Zimmer, G ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; GLYCOPROTEIN P; MEMBRANE LIPID; VERAPAMIL;

ANIMAL CELL; CELL PROLIFERATION; CELL VIABILITY; CHO CELL; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CYTOTOXICITY; ELECTRON SPIN RESONANCE; MEMBRANE FLUIDITY; MEMBRANE STRUCTURE; NONHUMAN;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CALCIUM CHANNEL BLOCKERS; CELL DIVISION; CELL MEMBRANE; CHO CELLS; CRICETINAE; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; ELECTRON SPIN RESONANCE SPECTROSCOPY; MEMBRANE FLUIDITY; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; STEREOISOMERISM; VERAPAMIL;

EID: 0031985239     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (19)

1. Alon N, Busche R, Tummler B, Riordan JR 1991 Membrane lipids of multidrug-resistant cells: chemical composition and physical state. In: Roninson IB (ed) Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells. Plenum, New York, pp 263-276
2. Barret JM, Calsou B, Larsen AK, Salles B 1994 A cisplatin-resistant murine leukemia cell line exhibits increased topoisomerase II activity. Mol Pharmacol 46: 431-436
3. Bornman WG, Roepe PD 1994 Analysis of drug transport kinetics in multidrug-resistant cells using a novel coumarin-vinblastin compound. Biochemistry 33: 12665-12675
4. Callaghan R, Van Gorkom LCM, Epand RM 1992 A comparison of membrane properties and compositon between cell lines selected and transfected for multidrug resistance. Br J Cancer 66: 781-786
5. Callaghan R, Stafford A, Epand RM 1993 Increased accumulation of drugs in a multidrug-resistent cell line by alteration of membrane biophysical properties. Biochim Biophys Acta 1175: 277-282
6. Drori S, Eytan GD, Assaraf YG 1995 Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability. Eur J Biochem 228: 1020-1029
7. Gaffney BJ, Lin DC 1976 Spin-label measurement of membrane-bound enzymes. In: Martonosi A (ed) The Enzymes of Biological Membranes. John Wiley and Sons, New York, pp 71-90
8. Gottesmann MM, Pastan I 1988 The multidrug transporter, a double-edged sword. J Biol Chem 263: 12163-12166
9. Jost PC, Griffith OH 1976 Instrumental aspects of spin labeling. In: Berliner LJ (ed) Spin Labeling Theory and Applications. Academic Press, New York, pp 251-271
10. Kayyali R, Marriott C, Wiseman H 1994 Tamoxifen decreases drug efflux from liposomes: relevance to its ability to reverse multidrug resistance in cancer cells? FEBS Lett 344: 221-224
11. Keith AD, Sharnoff M, Cohn GE 1973 A summary and evaluation of spin labels used as probes for biological membrane structure. Biochim Biophys Acta 300: 379-419
12. Kotoh S, Naito S, Yokomizo A, Kumazawa J, Asakuno K, Kohono K, Kuwano M 1994 Increased expression of DNA topoisomerase I gen and collateral sensitivity to camptothecin in human cisplatin-resistant bladder cancer cells. Cancer Res 54: 3248-3252
13. Ling V, Thompson LH 1974 Reduced permeability in CHO cells as a mechanism of resistance to colchicine. J Cell Physiol 83: 103-116
14. i homeostasis in multidrug-resistant (MDR) cells: Further characterization of a series of MDR cell lines expressing different levels of p-glycoprotein. Biochemistry 32: 11042-11056
15. Van Blitterswijk WJ, Van Hoeven RP, Van der Meer BW 1981 Lipid structural order parameters (reciprocal of fluidity) in biomembranes derived from steady-state fluorescence polarization measurements. Biochim Biophys Acta 644: 323-332
16. Wadkins RM, Houghton PJ 1993 The role of drug-lipid interactions in the biological activity of modulators of multidrug resistance. Biochim Biophys Acta 1153: 225-236
17. Yusa K, Tsuruo T 1989 Reversal mechanism of multidrug resistance by verapamil: Direct bindng of verapamil to P-glycoprotein on specific sites and transport of verapamil outwerd across the plasma membrane of K562/ADM cells. Cancer Res 49: 5002-5006
18. Zimmer G, Freisleben HJ, Fuchs J 1990 Influence of pH on sulfhydryl groups and fluidity of the mitochondrial membrane. Arch Biochem Biophys 282: 309-317
19. Zimmer G 1997 Overview of the role of lipoate in the enzyme complexes of energy metabolism and reducing equivalents. In: Fuchs J, Packer L, Zimmer G (eds) Lipoic Acid in Health and Disease. Marcel Dekker, New York, pp 67-86