Neurochemical changes in LPA1 receptor deficient mice - A putative model of schizophrenia

Neurochemical Research

Volumn 30, Issue 3, 2005, Pages 371-377

  Roberts, Claire ^a   Winter, Panida ^a   Shilliam, Claire S ^a   Hughes, Zoe A ^a   Langmead, Christopher ^a   Maycox, Peter R ^a   Dawson, Lee A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

5 HT; GABA; Glutamate; Release; Voltammetry

Indexed keywords

4 AMINOBUTYRIC ACID; AMINO ACID; ASPARTIC ACID; GLUTAMIC ACID; LPA1 RECEPTOR; POTASSIUM ION; RECEPTOR; SEROTONIN; TYROSINE; UNCLASSIFIED DRUG; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; LYSOPHOSPHATIDIC ACID RECEPTOR;

ANALYTIC METHOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DORSAL RAPHE NUCLEUS; FEMALE; GENE DELETION; GENE LOCUS; GENE TARGETING; HIPPOCAMPUS; IN VITRO STUDY; MOUSE; MOUSE STRAIN; NEUROCHEMISTRY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SCHIZOPHRENIA; ANIMAL; BRAIN LEVEL; ELECTROSTIMULATION; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOUSE MUTANT; RAPHE NUCLEUS;

AMINO ACIDS; ANIMALS; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTRIC STIMULATION; FEMALE; MICE; MICE, KNOCKOUT; NEUROTRANSMITTER AGENTS; RAPHE NUCLEI; RECEPTORS, LYSOPHOSPHATIDIC ACID; SCHIZOPHRENIA; SEROTONIN;

EID: 21144449972     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-005-2611-6     Document Type: Article

References (42)

1. R. M. Bilder 2001 Schizophrenia as a neurodevelopmental disorder Curr. Opin. Psychiatry 14 9 15
2. S. An M. A. Dickens T. Bleu O. G. Hallmark E. J. Goetzl 1997 Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid Biochem. Biophys. Res. Commun 231 619 622
3. J. Allard S. Barron J. Diaz C. Lubetzki B. Zalc J-C. Schwartz P. Sokoloff 1998 A rat G protein-coupled receptor selectively expressed in myelin-forming cells Eur. J. Neurosci 10 1045 1053
4. J. H. Hecht J. A. Weiner S. R. Post J. Chun 1996 Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex J. Cell Biol 135 1071 1083
5. E. J. Handford D. Smith L. Hewson G. McAllister M. Beer 2001 Edg2 receptor distribution in adult rat brain Neuroreport 12 757 760
6. Y. Liu R. Wada T. Yamashita Y. Mi C. X. Deng J. P. Hobson H. M. Rosenfeldt V. E. Nava S. S. Chae M. J. Lee C. H. Liu T. Hla S. Spiegel R. L. Proia 2000 Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation J. Clin. Invest 106 939 940
7. N. Fukushima J.A. Weiner J. Chun 2000 Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology Dev. Biol 228 6 18
8. S. M. Harrison C. Reavill G. Brown J. Brown J. E. Cluderay B. Crook C. Davies L. A. Dawson E. Grau C. Heidbreder P. Hemmati G. Hervieu A. Howarth Z. Hughes A. J. Hunter J. Latcham S. Pickering P. Pugh D. C. Rogers C. Shilliam P. R Maycox 2003 LPA-1 deficient mice have phenotypic changes observed in psychiatric disease Mol. Cell Neurosci 24 1170 1179
9. J. L. Waddington A. Lane P. Scully D. Meagher J. Quinn C. Larkin E. O'Callaghan 1999 Early cerebro-craniofacial dysmorphogenesis I schizophrenia: a lifetime trajectory model from neurodevelopmental basis to 'neuroprogressive' process J. Psychiatry Res 33 477 489
10. D. L. Braff M. A. Geyer 1990 Sensorimotor gating and schizophrenia Arch. Gen. Psychiatry 47 181 188
11. M. A. Geyer 1999 Assessing prepulse inhibition of startle in wild-type and knockout mice Psychopharmacology 147 11 13
12. G. Emilien J.-M. Maloteaux M. Geurts K. Hoogenberg S. Cragg 1999 Dopamine receptors-physiological understanding to therapeutic intervention potential Pharmacol. Therapeutics 84 133 156
13. A. Abi-Dargham M. Laruelle G. K. Aghajanian D. Charney J. Krystal 1997 The role of serotonin in the pathophysiology and treatment of schizophrenia J. Neuropsychiatry Clin. Neurosci 9 1 17
14. F. M. Benes S. Berretta 2001 GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder Neuropsychopharmacology 25 1 27
15. D. A. Lewis 2000 GABAergic local circuit neurons and prefrontal cortical dysfunction in schizophrenia Brain Res. Rev 31 270 276
16. A receptor α-1 subunit mRNA and human GABA transporter-1 (HGAT-1) mRNA expression Neuroscience 93 441 448
17. F.-A. Wiesel J. L. R. Andersson G. Westerberg I.-M. Wieselgren L. Bjerkenstedt L. Hagenfeldt B. Langstrom 1999 Tyrosine transport is regulated differently in patients with schizophrenia Schizophrenia Res 40 37 42
18. R. A. Bressan L. S. Pilowsky 2000 Imaging the glutamatergic system in vivo - relevance to schizophrenia Eur. J. Nucl. Med 27 1723 1731
19. J. S. Kim H. H. Kornhuber W. Schmid-Burgk B. Holzmuller 1980 Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia Neurosci. Lett 20 379 382
20. A. A. Noorbala S. Akhondzadeh R. Davari-Ashtiani H. Amini-Nooshabedi 1999 Piracetam in the treatment of schizophrenia: implications for the glutamate hypothesis of schizophrenia J. Clin. Pharm. Ther 24 369 374
21. Roberts, C. Winter, P. Shilliam, C. S. Atkins, A. R. Hughes, Z. A. Maycox, P. R. and Dawson, L. A. 2003. Neurochemical changes in the LPA-1 Knock-out Mouse. Pages 91-93 J. in Kehr J., K.Fuxe, U. Ungerstedt and T. Svensson (eds.),. Sweden: Karolinska University Press.
22. C. Roberts J. Watson M. Burton G. W. Price B. Jones 1996 Functional characterisation of the 5-HT terminal autoreceptor in the guinea-pig brain cortex Br. J. Pharmacol 117 384 388
23. L. A. Dawson J. M. Stow A. M. Palmer 1997 Improved temporal resolution of microdialysis measurement of glutamate and aspartate using capillary electrophoresis with laser induced fluorescence detection J. Chromatogr. B 694 455 460
24. C. Roberts G. W. Price 2001 Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study Neurosci. Lett 300 45 48
25. P. J. Harrison 1999 The neuropathology of schizophrenia: a critical review of the data and their interpretation Brain 122 593 624
26. P. J. Harrison S. L. Eastwood 2001 Neuropathological studies of synaptic connectivity in the hippocampal formation in schizophrenia Hippocampus 11 508 519
27. G. P. Reynolds C. Czudek H. Andrews 1990 Deficit and hemispheric asymmetry of GABA uptake sites in the hippocampus in schizophrenia Biol. Psychiatry 27 1038 1044
28. A receptor binding in the hippocampal formation of schizophrenic brain Synapse 22 338 349
29. J. D. Jentsch R. H. Roth 1999 The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia Neuropsychopharmacology 20 201 225
30. C. M. Adler A. K. Malhorta I. Elman R. Carson D. Pickar A. Breier 1999 Effects of NMDA receptor antagonist ketamine on striatal dopamine release in schizophrenia Schizophrenia Res 36 299
31. J. H. Krystal L. P. Karper J. P. Seibyl G. K. Freeman R. Delaney J. D. Bremner G. R. Heninger M. B. Bowers D. S. Charney 1994 Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans -psychotomimetic, perceptual, cognitive, and neuroendocrine responses Arch. Gen. Psychiatry 51 199 214
32. E. D. Luby B. D. Cohen G. Rosembum J. S. Gottlieb R. Kelley 1959 Study of a new schizophrenomimetic drug Sernyl Arch. Neurol. Psychiatry 81 363 369
33. B. K. Lipska D. R. Weinberger 2000 To model a psychiatric disorder in animals: Schizophrenia as a reality test Neuropsychopharmacology 23 223 239
34. N. R. Swerdlow M. A. Geyer D. L. Braff 2001 Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges Psychopharmacology 156 194 215
35. P. J. Fletcher D. Phil Z. F. Selhi A. Azampanah T. L. Sills 2001 Reduced brain serotonin activity disrupts prepulse inhibition of the acoustic startle reflex: effects of 5,7-dihydroxytryptamine and p-chlorophenylalanine Neuropsychopharmacology 24 399 409
36. J. H. Kehne R. A. Padich T. C. McCloskey V. L. Taylor C. J. Schmidt 1996 5-HT modulation of auditory and visual sensorimotor gating:I. Effects of 5-HT releasers on sound and light prepulse inhibition in Wistar rats Psychopharmacology 124 95 101
37. E. Rydin D. Schalling M. Asberg 1982 Rorschach ratings in depressed patients and suicidal patients with low levels of 5-hydroxyindoleacetic acid in cerebrospinal fluid Psych. Res 7 229 243
38. P. Hertel G. Nomikos M. Iurlo T. H. Svensson 1996 Risperidone: regional effects in vivo on release and metabolism of dopamine and serotonin in the rat brain Psychopharmacology 124 74 86
39. S. M. Dursun A. Szemis H. Andrews P. Whitaker M. A. Revely 2000 Effects of clozapine and typical antipsychotic drugs on plasma 5-HT turnover and impulsivity in patients with schizophrenia: a cross-sectional study J. Psych. Neurosci 25 347 352
40. A. Dahlstrom K. Fuxe 1964 Evidence for the existence of monoamine containing neurones in the CNS Acta Physiol. Scan 62 1 55
41. B. E. Kosofsky M. E. Molliver 1987 The serotonergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei Synapse 1 153 168
42. E. C. Azmitia M. Segal 1978 An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat J. Comp. Neurol 179 641 668