Effects of clozapine and typical antipsychotic drugs on plasma 5-HT turnover and impulsivity in patients with schizophrenia: A cross-sectional study

Journal of Psychiatry and Neuroscience

Volumn 25, Issue 4, 2000, Pages 347-352

  Dursun, Serdar M ^a,b   Szemis, Andrea ^a   Andrews, Harry ^a   Whitaker, Paul ^a   Reveley, Michael A ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Antipsychotic agents; Clozapine; Impulsive behavior; Schizophrenia; Serotonin

Indexed keywords

CLOZAPINE; NEUROLEPTIC AGENT; SEROTONIN;

ADULT; AGGRESSION; ARTICLE; CLINICAL ARTICLE; COST EFFECTIVENESS ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; FEMALE; HUMAN; IMPULSIVENESS; MALE; NEUROTRANSMITTER RELEASE; PERSONALITY DISORDER; SCHIZOPHRENIA; SCORING SYSTEM; TURNOVER TIME;

EID: 0033758584     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Mallya AR, Roos PD, Roebuck-Colgan K. Restraint, seclusion and clozapine. J Clin Psychiatry 1992;53:395-7.
2. Jones H, Curtis VA, Wright P, Lucey JV. Neuroendocrine evidence that clozapine's serotonergic antagonism is relevant to its efficacy in treating hallucinations and other positive schizophrenic symptoms. Am J Psychiatry 1998;155:838-40.
3. Curtis VA, Wright P, Reveley A, Kerwin R, Lucey JV. Effect of clozapine on d-fenfluramine-evoked neuroendocrine responses in schizophrenia and its relationship to clinical improvement. Br J Psychiatry 1995;166:642-6.
4. Breier A. Serotonin, schizophrenia and antipsychotic drug action. Schizophr Res 1995;14:187-202.
5. Owen RR, Gutierrez-Esteinou R, Hsiao J, Hadd K, Benkelfat C, Lawlor BA, Murphy DL, Pickar D. Effects of dozapine and fluphenazine treatment on responses to m-chlorophenylpiperazine infusions in schizophrenia. Arch Gen Psychiatry 1993;50:636-644.
6. Dursun SM, Reveley MA. Clozapine has a unique pharmacological profile [letter]. BMJ 1993;307:200.
7. Bleich A, Brown SL, Kahn R, van Praag HM. The role of serotonin in schizophrenia. Schizophr Bull 1988;14:297-315.
8. Braunig P, Rao ML, Flimmers R. Blood serotonin levels in suicidal patients with schizophrenia. Acta Psychiatr Scand 1989;79:186-9.
9. Muck-Seler D, Jakavljevic M, Deanovic Z. Platelet serotonin in subtypes of schizophrenia and unipolar depression. Psychiatry Res 1991;38:105-31.
10. Coccaro EF, Bergman CS, McClearn GE. Heritability of irritable impulsiveness: a study of twins reared together and apart. Psychiatry Res 1993;48:229-42.
11. Coccaro EF, Harvey PD, Kupsaw-Lawrence E, Herbert JL, Bernstein DP. Development of neuropharmacologically based behavioral assessments of impulsive aggressive behavior. J Neuropsychiatry Clin Neurosci 1991;3:S44-51.
12. Whitaker RP, Dursun SM, Davies T, Madira W. Measurement of platelet rich plasma 5-HT and platelet poor plasma 5-HIAA and 5-HT in normal adults [abstract]. Ann Clin Biochem 1996;6537:341.
13. Dursun SM, Whitaker RP, Andrews H, Reveley. Effects of aging on plasma 5-HT turnover in humans. Hum Psychopharm 1997;12:365-7.
14. Bearcroft CP, Farthing MJG, Perret D. Determination of 5-hydroxytryptamine, 5-hydroxyindoleactic acid and tryptophan in plasma and urine by HPLC with fluorimetric detection. Biomed Chromatogr 1995;9:23-7.
15. Okayli G, Ranjan R, Meltzer HY. The reduction of suicidality during clozapine treatment of neuroleptic-resistant schizophrenia; impact on risk-benefit assessment. Am J Psychiatry 1995;152:183-90.
16. Ratey JJ, Leveroni CL, Kilmer D, Gutheil CM, Swartz B. The effects of clozapine on severely aggressive psychiatric inpatients in a state hospital. J Clin Psychiatry 1993;54:219-23.
17. Banki CM. Alterations of CSF 5-HIAA and total blood serotonin content during clozapine treatment. Psychopharmacology 1978;56:195-8.
18. Ackenheil M, Blatt B, Lampart C. Effect of clozapine on 5-HIAA excretion in urine and CSF of psychotic patients and on serotonin metabolism in rat brain. Acta Vitaminol Enzymol 1975;29:79-84.
19. Depue RA, Spoont MR. 1986. Conceptualizing a serotonin trait. Ann NY Acad Sci 487:47-62.
20. Rydin E, Schalling D, Asberg M. Rorschach ratings in depressed and suicidal patients with low levels of 5-hydroxyindoleacetic acid in cerebrospinal fluid. Psychiatry Res 1982;7:229-43.
21. Asberg M, Thoren P, Traskman L, Bertilsson L, Rinberger V. "Serotonin depression" - a biochemical subgroup within the affective disorders? Science 1976;191:478-80.
22. Meltzer HY. Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia. Psychopharmacology 1989;99:S18-27.
23. Spivak B, Roitman S, Vered Y, Mester R, Graff E, Talmon Y, et al. Diminished suicidal and aggressive behavior, high plasma norepinephrine levels, and serum triglyceride levels in chronic neuroleptic-resistant schizophrenic patients maintained on clozapine. Clin Neuropharmacol 1998;21:245-50.