Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 11, 2005, Pages 2824-2828

  Singh, Sheo B ^a   Ondeyka, John G ^a   Liu, Weiguo ^a   Chen, Steve ^a   Chen, Tom S ^a   Li, Xiaohua ^a   Bouffard, Aileen ^a   Dropinski, James ^a   Jones, A Brian ^a   McCormick, Sherrie ^a   Hayes, Nancy ^a   Wang, Jianhua ^a   Sharma, Neelam ^a   MacNaul, Karen ^a   Hernandez, Melba ^a   Chao, Yu Sheng ^a   Baffic, Joanne ^a   Lam, My Hanh ^a   Burton, Charlotte ^a   Sparrow, Carl P ^a   Menke, John G ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Atherosclerosis; Cholesterol lowering; LXR; Natural product derivatives

Indexed keywords

CHOLESTEROL DERIVATIVE; DIMER; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HORMONE RECEPTOR STIMULATING AGENT; IMIDE; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PODOCARPIC ACID DERIVATIVE; TRIACYLGLYCEROL;

AREA UNDER THE CURVE; ARTICLE; DIMERIZATION; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; IC 50; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; AREA UNDER CURVE; BIOTRANSFORMATION; CELL LINE; CHOLESTEROL, HDL; CRICETINAE; DIMERIZATION; DITERPENES, ABIETANE; HUMANS; MALE; MICE; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

CRICETINAE;

EID: 21144445100     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.100     Document Type: Article

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