Serum levels of anti-myelin antibodies in relapsing-remitting multiple sclerosis patients during different phases of disease activity and immunomodulatory therapy

Disease Markers

Volumn 21, Issue 2, 2005, Pages 49-55

  Angelucci, Francesco ^a   Mirabella, Massimiliano ^a   Frisullo, Giovanni ^a   Caggiula, Marcella ^a   Tonali, Pietro Attilio ^a   Batocchi, Anna Paola ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

Antibodies; MBP; MOG; Multiple sclerosis; Relapse; Remission

Indexed keywords

ANTIBODY; BETA INTERFERON; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG EFFECT; FEMALE; HUMAN; IMMUNOMODULATION; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; RELAPSE; REMISSION;

EID: 21044448999     PISSN: 02780240     EISSN: None     Source Type: Journal    
DOI: 10.1155/2005/826817     Document Type: Article

References (41)

1. P. Amiguet, M.V. Gardinier, J.P. Zanetta and J.M. Matthieu, Purification and partial structural and functional characterization of mouse myelin/oligodendrocyte glycoprotein, J Neurochem 58 (1992), 1676-1682.
2. C.C. Bernard, T.G. Johns, A. Slavin, M. Ichikawa, C. Ewing, J. Liu and J. Bettadapura, Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis, J Mol Med 75 (1997), 77-88.
3. T. Berger, P. Rubner, F. Schautzer, R. Egg, H. Ulmer, I. Mayringer, E. Dilitz, F. Deisenhammer and M. Reindl, Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event, N Engl J Med 349 (2003), 139-145.
4. U. Brehm, S.J. Piddlesden, M.V. Gardinier and C. Linington, Epitope specificity of demyelinating monoclonal autoantibodies directed against the human myelin oligodendrocyte glycoprotein (MOG), J Neuroimmunol 97 (1999), 9-15.
5. K.A. Brokstad, M. Page, H. Nyland and L.R. Haaheim, Autoantibodies to myelin basic protein are not present in the serum and CSF of MS patients, Acta Neurol Scand 89 (1994), 407-411.
6. I. Catz and K.G. Warren, Intrathecal synthesis of autoantibodies to myelin basic protein in multiple sclerosis, Can. Neurol Sci 13 (1986), 21-24.
7. E. Colombo, K. Banki, A.H. Tatum, J. Daucher, P. Ferrante, R.S. Murray, P.E. Phillips and A. Perl, Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis, J Clin Invest 99 (1997), 1238-1250.
8. C.S. Clements, H.H. Reid, T. Beddoe, F.E. Tynan, M.A. Perugini, T.G. Johns, C.C. Bernard and J. Rossjohn, The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis, PNAS USA. 100 (2003), 11059-11064.
9. J. Correale, M. de los Milagros Bassani Molinas, Oligoclonal bands and antibody responses in multiple sclerosis, J Neurol 249 (2002), 375-389.
10. M.V. Gardinier, P. Amiguet, C. Linington and J.M. Matthieu, Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily, J Neurosci Res 33 (1992), 177-187.
11. C.P Genain, B. Cannella, S.L. Hauser and C.S. Raine, Identification of autoantibodies associated with myelin damage in multiple sclerosis, Nat. Med. 5 (1999), 170-175.
12. M.K. Gorny, Z. Wroblewska, D. Pleasure, S.L. Miller, A. Wajgt and H. Koprowski, CSF antibodies to myelin basic protein and oligodendrocytes in multiple sclerosis and other neurological diseases, Acta Neurol Scand 67 (1983), 338-347.
13. C.G. Haase, J. Guggenmos, U. Brehm, M. Andersson, T. Olsson, M. Reindl, J.M. Schneidewind, U.K. Zettl, F. Heidenreich, T. Berger, H. Wekerle, R. Hohlfeld and C. Linington, The fine specificity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls, J Neuroimmunol 114 (2001), 220-225.
14. N. Hellings, M. Baree, C. Verhoeven. M.B. D'hooghe, R. Medaer, C.C. Bernard, J. Raus and P. Stinissen, T-cell reactivity to multiple myelin antigens in multiple sclerosis patients and healthy controls, J Neurosci Res 63 (2001), 290-302.
15. N. Hellings, J. Raus and P. Stinissen, Insights into the immunopathogenesis of multiple sclerosis, Immunol Res 25 (2002), 27-51.
16. M. Hobom, M.K. Storch, R. Weissert, K. Maier, A. Radhakrishnan, B. Kramer, M. Bahr and R. Diem, Mechanisms and time course of neuronal degeneration in experimental autoimmune encephalomyelitis, Brain Pathol 14 (2004), 148-157.
17. R. Hohlfeld, M. Kerschensteiner, C. Stadelmann, H. Lassmann and H. Wekerle, The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis, J Neuroimmunol 107 (2000), 161-166.
18. T. Ichioka, K. Uobe, M. Stoskopf, Y. Kishimoto, G. Tennekoon and W.W. Tourtellotte, Antigalactocerebrosidase antibodies in human cerebrospinal fluid determined by enzyme-linked immunosorbent assay (ELISA), Neurochem Res 13 (1988), 203-207.
19. A. Iglesias, J. Bauer, T. Litzenburger, A. Schubart and C. Linington, T cell and B cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis, Glia 36 (2001), 220-234.
20. A. Karni, R. Bakimer-Kleiner, O. Abramsky and A. Ben-Nun, Elevated levels of antibody to myelin oligodendrocyte glycoprotein is not specific for patients with multiple sclerosis, Arch Neurol 56 (1999), 311-315.
21. A. Kennel De March, M. De Bouwerie, M.N. Kolopp-Sarda, G.C. Faure, M.C. Bene and C.C. Bernard, Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis, J Neuroimmunol 135 (2003), 117-125.
22. M. Kerschensteiner, E. Gallmeier, L. Behrens, V.V. Leal, T. Misgeld, W.E. Klinkert, R. Kolbeck, E. Hoppe, R.L. Oropeza-Wekerle, I. Bartke, C. Stadelmann, H. Lassmann, H. Wekerle and R. Hohlfeld, Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation? J Exp Med 189 (1999), 865-870.
23. K. Kimura, S.F. Hunter, M.S. Thollander, E.V. Loftus, L.J. Melton, P.C. O'Brien, M. Rodriguez and S.F. Phillips, Concurrence of inflammatory bowel disease and multiple sclerosis, Mayo Clinic Proc 75 (2000), 802-806.
24. V. Lampasona, D. Franciotta, R. Furlan, S. Zanaboni, R. Fazio, E. Bonifacio, G. Comi and G. Martino, Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects, Neurology 62 (2004), 2092-2094.
25. 2 autoantigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane, Clin Exp. Immunol 66 (1986), 423-434.
26. C. Linnington, M. Bradl, H. Lassmann, C. Brunner and K. Vaas, Augmentation of demyelination in rag acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/ oligodendrocyte glycoprotein, Am J Pathol 130 (1988), 443-454.
27. C. Linnington, M. Webb and P.L. Woodhams, A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody, J Neuroimmunol 6 (1984), 387-396.
28. C. Lucchinetti, W. Bruck, J. Parisi, B. Scheithauer, M. Rodriguez and H. Lassmann, Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination, Ann Neurol 47 (2000), 707-717.
29. R. Mantegazza, P. Cristaldini, P. Bernasconi, F. Baggi, R. Pedotti, I. Piccini, N. Mascoli, L.L. Mantia, C. Antozzi, O. Simoncini, F. Cornelio and C. Milanese, Anti-MOG autoantibodies in Italian multiple sclerosis patients: specificity, sensitivity and clinical association, Int Immunol 16 (2004), 559-555.
30. W.I. McDonald, A. Compston, G. Edan, D. Goodkin, H.P. Hartung, F.D. Lublin, H.F. McFarland, D.W. Paty, C.H. Polman, S.C. Reingold, M. Sandberg-Wollheim, W. Sibley. A. Thompson, S. van den Noort, B.Y. Weinshenker and J.S. Wolinsky, Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis, Ann Neurol 50 (2001), 121-127.
31. H. Neumann, Molecular mechanisms of axonal damage in inflammatory central nervous system diseases, Curr Opin Neurol 16 (2003), 267-273.
32. K.C. O'Connor, T. Chitnis, D.E. Griffin, S. Piyasirisilp, A. Bar-Or, S. Khoury, K.W. Wucherpfennig and D.A. Hafler, Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions, J Neuroimmunol 136 (2003), 140-148.
33. T. Olsson, S. Baig, B. Hojeberg and H. Link, Antimyelin basic protein and antimyelin antibody-producing cells in multiple sclerosis, Ann Neurol 27 (1990), 132-136.
34. H.S. Panitch, C.J. Hooper and K.P. Johnson, CSF antibody to myelin basic protein: measurement in patients with multiple sclerosis and subacute sclerosing panencephalitis, Arch Neurol 37 (1980), 206-209.
35. D. Pham-Dinh, M.G. Mattei, J.L. Nussbaum, G. Roussel, P. Pontarotti, N. Roeckel, I.H. Mather, K. Artzt, K.P. Lindahl and A. Dautigny, Myelin/oligodendrocyte glycoprotein is a member of a subset of the immunoglobulin superfamily encoded within the major histocompatibility complex, PNAS USA 90 (1993), 7990-7994.
36. C.S. Raine, B. Cannella, S.L. Hauser and C.P. Genain, Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: a case for antigen-specific antibody mediation, Ann Neurol 46 (1999), 144-160.
37. M. Schwartz, G. Moalem, R. Leibowitz-Amit, E. Yoles, F. Mor and I.R. Cohen, Beneficial immune activity after CNS injury: prospects for vaccination. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy, Nat Med 5 (1999), 49-55.
38. N.J. Scolding, S. Frith, C. Linington, B.P. Morgan, A.K. Campbell and D.A. Compston, Myelin-oligodendrocyte glycoprotein (MOG) is a surface marker of oligodendrocyte maturation, J Neuroimmunol 22 (1989), 169-176.
39. A. Seamons, A. Perchellet and I. Goverman, Immune tolerance to myelin proteins, Immunol Res 28 (2003), 201-221.
40. M.K. Storch, A. Stefferl, U. Brehm, R. Weissert, E. Wallstrom, M. Kerschensteiner, T. Olsson, C. Linington and H. Lassmann, Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology, Brain Pathol 8 (1998), 681-694.
41. J.W. Terryberry, G. Thor and J.B. Peter, Autoantibodies in neurodegenerative diseases: antigen-specific frequencies and intrathecal analysis, Neurobiol Aging 19 (1998), 205-216.