Development of a prostaglandin D2 receptor antagonist: Discovery of a new chemical lead

European Journal of Medicinal Chemistry

Volumn 40, Issue 5, 2005, Pages 505-519

  Torisu, Kazuhiko ^a   Kobayashi, Kaoru ^a   Iwahashi, Maki ^a   Egashira, Hiromu ^a   Nakai, Yoshihiko ^a   Okada, Yutaka ^a   Nanbu, Fumio ^a   Ohuchida, Shuichi ^a   Nakai, Hisao ^a   Toda, Masaaki ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

Antagonist; DP receptor; Prostaglandin

Indexed keywords

(5 HYDROXY 2 METHYL 1H INDOL 3 YL)ACETIC ACID; 2 BUTOXY N' (ETHYLIDENE) N (4 METHOXYPHENYL)BENZOHYDRAZIDE; 2 METHYLINDOLE 4 ACETIC ACID DERIVATIVE; 3 BUTOXY N' (ETHYLIDENE) N (4 METHOXYPHENYL)BENZOHYDRAZIDE; 4 BUTOXY N (4 CHLOROPHENYL) N' (ETHYLIDENE)BENZOHYDRAZIDE; 4 BUTOXY N' (ETHYLIDENE) N (4 ISOPROPYLPHENYL)BENZOHYDRAZIDE; 4 BUTOXY N' (ETHYLIDENE) N (4 METHOXYPHENYL)BENZOHYDRAZIDE; 4 BUTOXY N' (ETHYLIDENE) N (4 METHYLPHENYL)BENZOHYDRAZIDE; 4 BUTOXY N' (ETHYLIDENE) N PHENYLBENZOHYDRAZIDE; 4 ETHOXY N' (ETHYLIDENE) N (4 FLUOROPHENYL)BENZOHYDRAZIDE; 4 ETHOXY N' (ETHYLIDENE) N (4 METHOXYPHENYL)BENZOHYDRAZIDE; 4 METHOXY N' (ETHYLIDENE) N (4 METHOXYPHENYL)BENZOHYDRAZIDE; [1 (2 BUTOXYBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 (3 BUTOXYBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 (4 BUTOXYBENZOYL) 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 (4 BUTOXYBENZOYL) 2,5 DIMETHYL 1H INDOL 3 YL]ACETIC ACID; [1 (4 BUTOXYBENZOYL) 5 ISOPROPYL 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 (4 BUTOXYBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 (4 ETHOXYBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 (4 METHOXYBENZOYL) 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 [4 (HEPTYLOXY)BENZOYL] 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [1 [4 (HEXYLOXY)BENZOYL] 5 METHOXY 2 METHYL 1H INDOL 3 YL]ACETIC ACID; [5 FLUORO 2 METHYL 1 (4 PENTYLBENZOYL) 1H INDOL 3 YL]ACETIC ACID; [5 METHOXY 2 METHYL 1 (4 PENTYLBENZOYL) 1H INDOL 3 YL]ACETIC ACID; [5 METHOXY 2 METHYL 1 (4 PROPOXYBENZOYL) 1H INDOL 3 YL]ACETIC ACID; [5 METHOXY 2 METHYL 1 [4 (PENTYLOXY)BENZOYL] 1H INDOL 3 YL]ACETIC ACID; ACETIC ACID DERIVATIVE; CYCLIC AMP; INDOMETACIN; INDOMETACIN DERIVATIVE; N (4 BUTOXY)BENZOYL 2 METHYLINDOLE 4 ACETIC ACID; N' (ETHYLIDENE) N (4 HEPTYLOXY) N (4 METHOXYPHENYL)BENZOHYDRAZIDE; N' (ETHYLIDENE) N (4 HEXYLOXY) N (4 METHOXYPHENYL)BENZOHYDRAZIDE; N' (ETHYLIDENE) N (4 METHOXYPHENYL) 4 PROPOXYBENZOHYDRAZIDE; N' (ETHYLIDENE) N (4 METHOXYPHENYL)4 (PENTYLOXY)BENZOHYDRAZIDE; N' (ETHYLIDENE) N (4 METHOXYPHENYL)4 PENTYLBENZOHYDRAZIDE; PROSTAGLANDIN D2 RECEPTOR; PROSTAGLANDIN RECEPTOR; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; DRUG DERIVATIVE; IMMUNOGLOBULIN RECEPTOR; INDOLEACETIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; IN VITRO STUDY; MALE; NONHUMAN; PHARMACOLOGICAL BLOCKING; RAT; RECEPTOR AFFINITY; RECEPTOR BLOCKING; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; ANIMAL; AREA UNDER THE CURVE; BINDING COMPETITION; CHEMISTRY; CHO CELL; DRUG ANTAGONISM; HALF LIFE TIME; HAMSTER; MASS SPECTROMETRY; METABOLISM; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSIOLOGY; SYNTHESIS;

ANIMALS; AREA UNDER CURVE; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; CYCLIC AMP; HALF-LIFE; INDOLEACETIC ACIDS; INDOMETHACIN; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 21044439801     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.11.011     Document Type: Article

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