Cell cycle kinetic dysregulation in HIV-infected normal lymphocytes

Cytometry Part A

Volumn 66, Issue 1, 2005, Pages 41-51

  Asmuth, David M ^a,d   Wang, Nan ^b   Lu, Ying ^a   Li, Xiao Dong ^a   Reece, Lisa ^b   Terry, Nicholas H A ^c   Pollard, Richard B ^a   Nokta, Mostafa ^b   Leary, James F ^b   White, R Allen ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

G2 phase; Human immunodeficiency virus type 1 pathogenesis; Kinetics; S phase; Virus cell interactions

Indexed keywords

BROXURIDINE; GAG PROTEIN; VIRUS ANTIGEN;

ANTIBODY LABELING; ARTICLE; CELL CULTURE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DIVISION; CELL FRACTIONATION; CELL KINETICS; CELL LOSS; CELL POPULATION; CONTROLLED STUDY; DNA CONTENT; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE; MATHEMATICAL MODEL; PRIORITY JOURNAL; STAINING;

BROMODEOXYURIDINE; CELL CYCLE; DNA; FLOW CYTOMETRY; HIV-1; HUMANS; KINETICS; LEUKOCYTES, MONONUCLEAR; MODELS, BIOLOGICAL;

EID: 20944448380     PISSN: 15524922     EISSN: None     Source Type: Journal    
DOI: 10.1002/cyto.a.20148     Document Type: Article

References (41)

1. Op De Beeck A, Caillet-Fauquet P. Viruses and the cell cycle. Prog Cell Cycle Res 1997;3:1-19.
2. Marechal V, Piolot T. Lytic infection by double-strand DNA viruses and cell cycle alterations. Pathol Biol 2000;48:289-300.
3. Miedema F, Petit AJ, Terpstra FG, Schattenkerk JK, de Wolf F, Al BJ, Roos M, Lange JM, Danner SA, Goudsmit J. Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occurs. J Clin Invest 1988;82:1908-1914.
4. Clerici M, Stocks NI, Zajac RA, Boswell RN, Lucey DR, Via CS. Shearer GM. Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical staging. J Clin Invest 1989;84:1892-1899.
5. Connick E, Lederman MM, Kotzin BL, Spritzler J, Kuritzkes DR, St Clair M, Sevin AD, Fox L, Chiozzi MH, Leonard JM, Rousseau F, D'Arc RJ, Martinez A, Kessler H, Landay A. Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response. J Infect Dis 2000;181:358-363.
6. Sieg SF, Harding CV, Lederman MM. HIV-1 infection impairs cell cycle progression of CD4(+) T cells without affecting early activation responses. J Clin Invest 2001;108:757-764.
7. Patki AH, Zielske SP, Sieg SF, Lederman MM. Preferential S phase entry and apoptosis of CD4(+) T lymphocytes of HIV-1-infected patients after in vitro cultivation. Clin Immunol 2000;97:241-247.
8. Bartz SR, Rogel ME, Emerman M. Human immunodeficiency virus type 1 cell cycle control: Vpr is cytostatic and mediates G2 accumulation by a mechanism which differs from DNA damage checkpoint control. J Virol 1996;70:2324-2331.
9. Emerman M. HIV-1, Vpr and the cell cycle. Curr Biol 1996;6:1096-1103.
10. Stevenson M, Brichacek B, Heinzinger N, Swindells S, Pirruccello S, Janoff E, Emerman M. Molecular basis of cell cycle dependent HIV-1 replication. Implications for control of virus burden. Adv Exp Med Biol 1995;374:33-45.
11. Zack JA. The role of the cell cycle in HIV-1 infection. Adv Exp Med Biol 1995;374:27-31.
12. Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS. The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle. J Virol 1995;69:6304-6313.
13. Re F, Braaten D, Franke EK, Luban J. Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting the activation of p34cdc2-cyclin B. J Virol 1995;69:6859-6864.
14. He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR. Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activity. J Virol 1995;69:6705-6711.
15. Berry LD, Gould KL. Regulation of Cdc2 activity by phosphorylation at T14/Y15. Prog Cell Cycle Res 1996;2:99-105.
16. Goh WC, Manel N, Emerman M. The human immunodeficiency virus Vpr protein binds Cdc25C: implications for G2 arrest. Virology 2004;318:337-349.
17. Basi G, Draetta G. The cdc2 kinase: structure, activation, and its role at mitosis in vertebrate cells. In: Hutchison C, Glover DM, editors. Cell cycle control. Oxford: Oxford University Press; 1995. p 106-143.
18. Li CJ, Wang C, Friedman DJ, Pardee AB. Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1995;92:5461-5464.
19. Duan L, Ozaki I, Oakes JW, Taylor JP, Khalili K, Pomerantz RJ. The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication. J Virol 1994;68:4302-4313.
20. Levine AJ. P53. the cellular gatekeeper for growth and division. Cell 1997;88:323-331.
21. Clark E, Santiago F, Deng L, Chong S, de La FC, Wang L, Fu P, Stein D, Denny T, Lanka V, Mozafari F, Okamoto T, Kashanchi F. Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1. J Virol 2000;74:5040-5052.
22. Emerman M, Malim MH. HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology. Science 1998;280:1880-1884.
23. Goh WC, Rogel ME, Kinsey CM, Michael SF, Fultz PN, Nowak MA, Hahn BH, Emerman M. HIV-1 Vpr increases viral expression by manipulation of the cell cycle: a mechanism for selection of Vpr in vivo. Nat Med 1998;4:65-71.
24. Gozlan J, Lathey JL, Spector SA. Human immunodeficiency virus type 1 induction mediated by genistein is linked to cell cycle arrest in G2. J Virol 1998;72:8174-8180.
25. Hartwell LH, Kastan MB. Cell cycle control and cancer. Science 1994;266:1821-1828.
26. Antognoni P, Bignardi M, Cazzaniga LF, Poli AM, Richetti A, Bossi A, Rampello G, Barbera F, Soatti C, Bardelli D, Giordano M, Danova M. Accelerated radiation therapy for locally advanced squamous cell carcinomas of the oral cavity and oropharynx selected according to tumor cell kinetics-a phase II multicenter study. Int J Radiat Oncol Biol Phys 1996;36:1137-1145.
27. Terry NH, White RA, Meistrich ML, Calkins DR Evaluation of flow cytometric methods for determining population potential doubling times using cultured cells. Cytometry 1991;12:234-241.
28. Terry NH, Meistrich ML, Roubein LD, Lynch PM, Dubrow RA, Rich TA. Cellular kinetics in rectal cancer. Br J Cancer 1995;72:435-441.
29. Sarkaria JN, Gibson DF, Jordan VC, Fowler JF, Lindstrom MJ, Mulcahy RT. Tamoxifen-induced increase in the potential doubling time of MCF-7 xenografts as determined by bromodeoxyuridine labeling and flow cytometry. Cancer Res 1993;53:4413-4417.
30. Corvo R, Giaretti W, Geido E, Sanguineti G, Orecchia R, Scala M, Garaventa G, Mora E, Vitale V. Cell kinetics and tumor regression during radiotherapy in head and neck squamous-cell carcinomas. Int J Cancer 1996;68:151-155.
31. Darzynkiewicz Z, Bedner E, Smolewski P. Flow cytometry in analysis of cell cycle and apoptosis. Semin Hematol 2001;38:179-193.
32. Wersto RP, Chrest FJ, Leary JF, Morris C, Stetler-Stevenson M, Gabrielson E. Doublet discrimination in DNA cell-cycle analysis. Cytometry 2001;46:296-306.
33. White RA, Meistrich ML, Pollack A, Terry NH. Simultaneous estimation of T(G2+M), T(S), and T(pot) using single sample dynamic tumor data from bivariate DNA-thymidine analogue cytometry. Cytometry 2000;41:1-8.
34. 2M using bivariate BrdUrd/DNA flow cytometry. Cytometry 2005;66.
35. Dyrhol-Riise AM, Ohlsson M, Skarstein K, Nygaard SJ, Olofsson J, Jonsson R, Asjo B. T cell proliferation and apoptosis in HIV-1-infected lymphoid tissue: impact of highly active antiretroviral therapy. Clin Immunol 2001;101:180-191.
36. Orenstein JM, Bhat N, Yoder C, Fox C, Polis MA, Metcalf JA, Kovacs JA, Falloon J, Walker RE, Masur H, Lane HC, Davey RT. Rapid activation of lymph nodes and mononuclear cell HIV expression upon interrupting highly active antiretroviral therapy in patients after prolonged viral suppression. AIDS 2000;14:1709-1715.
37. Combadière B, Blanc C, Li T, Carcelain G, Delaugerre C, Calvez V, Tubiana R, Debre P, Katlama C, Autran B. CD4+Ki67+ lymphocytes in HIV-infected patients are effector T cells accumulated in the G1 phase of the cell cycle. Eur J Immunol 2000;30:3598-3603.
38. Ndolo T, Dhillon NK, Nguyen H, Guadalupe M, Mudryj M, Dandekar S. Simian immunodeficiency virus Nef protein delays the progression of CD4+ T cells through G1/S phase of the cell cycle. J Virol 2002;76:3587-3595.
39. Stivahtis GL, Soares MA, Vodicka MA, Hahn BH, Emerman M. Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology. J Virol 1997;71:4331-4338.
40. Flanelles V, Jowett JB, Li QX, Xie Y, Hahn B, Chen IS. Vpr-induced cell cycle arrest is conserved among primate lentiviruses. J Virol 1996;70:2516-2524.
41. Poon B, Grovit-Ferbas K, Stewart SA, Chen ISY. Cell cycle arrest by Vpr in HIV-1 virions and insensitivity to antiretroviral agents. Science 1998;281:266-269.