Preferential S phase entry and apoptosis of CD4+ T lymphocytes of HIV-1-infected patients after in vitro cultivation

Clinical Immunology

Volumn 97, Issue 3, 2000, Pages 241-247

  Patki, Abhay H ^a   Zielske, Steven P ^a   Sieg, Scott F ^a   Lederman, Michael M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

BrdU; Cell cycle; Flow cytometry; HIV 1 infection; T cell apoptosis

Indexed keywords

CD4 ANTIGEN; PROPIDIUM IODIDE;

APOPTOSIS; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL SEPARATION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; KINETICS; MALE; PRIORITY JOURNAL; STAINING; T LYMPHOCYTE;

EID: 0033673881     PISSN: 15216616     EISSN: None     Source Type: Journal    
DOI: 10.1006/clim.2000.4940     Document Type: Article

References (29)

1. + T cells from human immunodeficiency virus-infected asymptomatic individuals
2. Programmed death of T cells in HIV- 1 infection
3. Programmed cell death in AIDS-related HIV and SIV infections
4. Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type- 1 infected patients and in CD4 crosslinked PBMCs from normal individuals
5. Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease
6. Apoptosis in HIV infection
7. + blood lymphocytes are rapidly killed in vitro by contact with autologous human immunodeficiency virus-infected cells
8. Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden
9. Programmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD 4 and CD8 T cells correlates with lymphocyte activation and with disease progression
10. +-T-cell counts spontaneous apoptosis and Fas expression in peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1-infected subjects
11. HIV infection perturbs DNA content of lymphoid cells: Partial correction after 'suppression' of virus replication
12. Follicular dendritic cells and human immunodeficiency virus infectivity
13. + T lymphocytes in the lung of acquired immunodeficiency syndrome patients harbor human immunodeficiency virus type 1
14. Quantitative cell cycle analysis
15. Unscheduled cyclin B expression and p34 cdc2 activation in T lymphocytes from HIV-infected patients
16. + patients: Correlation with clinical progression and T cell loss
17. Regulation of cell division cycle pregression by bcl-2 expression: A potential mechanism for inhibition of programmed cell death
18. Propriocidal apoptosis of mature T lymphocytes coours at S phase of the cell cycle
19. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis
20. + T lymphocytes in HIV-1 infection as measured by Ki- 67 antigen
21. + T cells correlate with plasma human immunodeficiency virus (HIV-1) RNA level in HIV- 1 infection
22. + T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy
23. Cell cycling in HIV Infection: Analysis of in vivo activated lymphocytes
24. Rapid turnover of T lymphocytes in HIV-1 infection and its reduction by HAART: A kinetic study using deuerated glucose
25. 2H-glucose demonstrate differential effects of HIV on lymphocyte and monocyte proliferation and substantially enhanced lymphocyte proliferation in HIV-infected patients receiving IL-2 therapy
26. Differential expression profiles of apoptosis-affecting genes in HIV-infected cell lines and patient T cells
27. + cell subset in HIV disease implicate replicative senescence in HIV pathogenesis
28. + T cell turnover
29. + T cells