Discovery of a β-MSH-derived MC-4R selective agonist

Journal of Medicinal Chemistry

Volumn 48, Issue 9, 2005, Pages 3095-3098

  Mayer, John P ^a   Hsiung, Hansen M ^a   Flora, David B ^a   Edwards, Patrick ^a   Smith, Dennis P ^a   Zhang, Xing Yue ^a   Gadski, Robert A ^a   Heiman, Mark L ^a   Hertel, JeAnne L ^a   Emmerson, Paul J ^a   Husain, Saba ^a   O'Brien, Thomas P ^a   Kahl, Steven D ^a   Smiley, David L ^a   Zhang, Lianshan ^a   DiMarchi, Richard D ^a   Yan, Liang Zeng ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; ANTIOBESITY AGENT; BETA INTERMEDIN; CORTICOTROPIN; G PROTEIN COUPLED RECEPTOR; GAMMA INTERMEDIN; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 4 RECEPTOR AGONIST; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BODY WEIGHT; CONTROLLED STUDY; DERIVATIZATION; DIETARY INTAKE; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; ENERGY BALANCE; FOOD INTAKE; HUMAN; HUMAN CELL; LIFESTYLE; NONHUMAN; OBESITY; RAT;

ANIMALS; ANTI-OBESITY AGENTS; BETA-MSH; BODY WEIGHT; CELL LINE; EATING; HUMANS; OLIGOPEPTIDES; RADIOLIGAND ASSAY; RATS; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20944438749     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0501432     Document Type: Article

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