|
Volumn 17, Issue 4, 2002, Pages 227-233
|
Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents
|
Author keywords
Inhibitors; PDE5; Pyrazolopyridazinones
|
Indexed keywords
6 BENZYL 3 METHYL 1 ISOPROPYL 4 PHENYLPYRAZOLO[3,4 D]PYRIDAZIN 7(6H)ONE;
DIHYDROPYRIDINE DERIVATIVE;
FUSED CARBON NITROGEN HETEROCYCLE;
ISOXAZOLE DERIVATIVE;
PERIPHERAL VASODILATING AGENT;
PHOSPHODIESTERASE INHIBITOR;
PYRAZOLO[3,4 D]PYRIDAZINONE DERIVATIVE;
PYRIDAZINONE DERIVATIVE;
PYRIDINE DERIVATIVE;
PYRROLE DERIVATIVE;
SILDENAFIL;
UNCLASSIFIED DRUG;
VARDENAFIL;
ZAPRINAST;
CGMP BINDING, CGMP SPECIFIC 3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE;
CGMP-BINDING, CGMP-SPECIFIC 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE;
CYCLIC GMP PHOSPHODIESTERASE;
PHOSPHODIESTERASE;
PHOSPHODIESTERASE 6;
PYRIDAZINE DERIVATIVE;
VASODILATOR AGENT;
ANTIINFLAMMATORY ACTIVITY;
ARTICLE;
CONTROLLED STUDY;
DRUG ACTIVITY;
DRUG SCREENING;
DRUG SELECTIVITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ERECTILE DYSFUNCTION;
HUMAN;
IC 50;
MOLECULAR MODEL;
PRIORITY JOURNAL;
STRUCTURE ACTIVITY RELATION;
THROMBOCYTE;
DRUG EFFECT;
ENZYMOLOGY;
ISOLATION AND PURIFICATION;
SYNTHESIS;
3',5'-CYCLIC-GMP PHOSPHODIESTERASE;
BLOOD PLATELETS;
HUMANS;
INHIBITORY CONCENTRATION 50;
PHOSPHODIESTERASE INHIBITORS;
PHOSPHORIC DIESTER HYDROLASES;
PYRIDAZINES;
STRUCTURE-ACTIVITY RELATIONSHIP;
VASODILATOR AGENTS;
|
EID: 0036700892
PISSN: 14756366
EISSN: None
Source Type: Journal
DOI: 10.1080/1475636021000008494 Document Type: Article |
Times cited : (22)
|
References (20)
|