Rejection severity directly correlates with myocyte apoptosis in pig-to-baboon cardiac xenotransplantation

Journal of Heart and Lung Transplantation

Volumn 24, Issue 7, 2005, Pages 841-847

  Weaver, Joel G R ^a,b   McGregor, Christopher G A ^a   Tazelaar, Henry D ^a   Badley, Andrew D ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; ENZYME PRECURSOR; PROCASPASE 3; REGULATOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BABOON; CARDIAC GRAFT REJECTION; CELL COUNT; CELL DEATH; CELL DIVISION; CELL STRUCTURE; CHROMATIN; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ENZYME DEGRADATION; HEART GRAFT; HEART MUSCLE CELL; HEART TRANSPLANTATION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LINEAR REGRESSION ANALYSIS; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SWINE; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; XENOGRAFT; XENOTRANSPLANTATION;

ANIMALS; APOPTOSIS; GRAFT REJECTION; HEART TRANSPLANTATION; IN SITU NICK-END LABELING; MUSCLE CELLS; PAPIO ANUBIS; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 20744440841     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2004.05.017     Document Type: Article

References (33)

1. K.R. McCurry, D.L. Kooyman, C.G. Alvarado Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury Nat Med 1 1995 423 427
2. G.W. Byrne, K.R. McCurry, M.J. Martin, S.M. McClellan, J.L. Platt, J.S. Logan Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage Transplantation 63 1997 149 155
3. J.R. Leventhal, A.P. Dalmasso, J.W. Cromwell Prolongation of cardiac xenograft survival by depletion of complement Transplantation 55 1993 857 865
4. T. Kobayashi, S. Taniguchi, F.A. Neethling Delayed xenograft rejection of pig-to-baboon cardiac transplants after cobra venom factor therapy Transplantation 64 1997 1255 1261
5. Z.E. Holzknecht, K.L. Kuypers, T.B. Plummer Apoptosis and cellular activation in the pathogenesis of acute vascular rejection Circ Res 91 2002 1135 1141
6. J.T. Beranek Apoptosis is the main mechanism of cardiomyocyte death in the hyperacute rejection of heart xeno- and allografts Transplantation 64 1997 1632 1633
7. J.T. Beranek Myocardial defects in hyperacute cardiac rejection evidence of cardiomyocyte apoptosis Transplantation 70 2000 697 698
8. J.T. Beranek Further evidence of cardiomyocyte apoptosis in hyperacute rejection J Heart Lung Transplant 21 2002 713 714
9. D. Kanduc, A. Mittelman, R. Serpico Cell death apoptosis versus necrosis Int J Oncol 21 2002 165 170
10. A. Shimizu, Y. Masuda, H. Kitamura Complement-mediated killing of mesangial cells in experimental glomerulonephritis cell death by a combination of apoptosis and necrosis Nephron 86 2000 152 160
11. T.C. Somervaille, D.C. Linch, A. Khwaja Growth factor withdrawal from primary human erythroid progenitors induces apoptosis through a pathway involving glycogen synthase kinase-3 and Bax Blood 98 2001 1374 1381
12. S.M. Davidson, A. Stephanou, D.S. Latchman FLIP protects cardiomyocytes from apoptosis induced by simulated ischemia/reoxygenation, as demonstrated by short hairpin-induced (shRNA) silencing of FLIP mRNA J Mol Cell Cardiol 35 2003 1359 1364
13. Y.Q. Li, P. Chen, A. Haimovitz-Friedman, R.M. Reilly, C.S. Wong Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation Cancer Res 63 2003 5950 5956
14. S. Fulda, E. Meyer, C. Friesen, S.A. Susin, G. Kroemer, K.M. Debatin Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis Oncogene 20 2001 1063 1075
15. G. Berke The CTL's kiss of death Cell 81 1995 9 12
16. P.A. Henkart, M.S. Williams, C.M. Zacharchuk, A. Sarin Do CTL kill target cells by inducing apoptosis? Semin Immunol 9 1997 135 144
17. D.H. Adams, R.H. Chen, A. Kadner, S. Naficy Technique for heterotopic pig heart xenotransplantation in primates Ann Thorac Surg 68 1999 265 268
18. M.J. Goddard, J. Dunning, J. Horsley, C. Atkinson, G. Pino-Chavez, J. Wallwork Histopathology of cardiac xenograft rejection in the pig-to-baboon model J Heart Lung Transplant 21 2002 474 484
19. K.A. Jellinger Cell death mechanisms in neurodegeneration J Cell Mol Med 5 2001 1 17
20. J.S. Braun, R. Novak, P.J. Murray Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus J Infect Dis 184 2001 1300 1309
21. D. Wencker, M. Chandra, K. Nguyen A mechanistic role for cardiac myocyte apoptosis in heart failure J Clin Invest 111 2003 1497 1504
22. A. Abbate, G.G. Biondi-Zoccai, A. Baldi Pathophysiologic role of myocardial apoptosis in post-infarction left ventricular remodeling J Cell Physiol 193 2002 145 153
23. R.S. Hotchkiss, K.W. Tinsley, P.E. Swanson Depletion of dendritic cells, but not macrophages, in patients with sepsis J Immunol 168 2002 2493 2500
24. C.M. Coopersmith, P.E. Stromberg, W.M. Dunne Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis JAMA 287 2002 1716 1721
25. S. Fulda, E. Meyer, K.M. Debatin Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression Oncogene 21 2002 2283 2294
26. S. Kugler, G. Straten, F. Kreppel, S. Isenmann, P. Liston, M. Bahr The X-linked inhibitor of apoptosis (XIAP) prevents cell death in axotomized CNS neurons in vivo Cell Death Differ 7 2000 815 824
27. L. Zender, S. Hutker, C. Liedtke Caspase 8 small interfering RNA prevents acute liver failure in mice Proc Natl Acad Sci U S A 100 2003 7797 7802
28. J. Ji, M. Wernli, T. Klimkait, P. Erb Enhanced gene silencing by the application of multiple specific small interfering RNAs FEBS Lett 552 2003 247 252
29. E. Song, J. Chen, B. Antus, F. Su, M. Wang, M.S. Exton Adenovirus-mediated Bcl-2 gene transfer inhibits apoptosis and promotes survival of allogeneic transplanted hepatocytes Surgery 130 2001 502 511
30. F.H. Bach, C. Ferran, P. Hechenleitner Accommodation of vascularized xenografts expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment Nat Med 3 1997 196 204
31. F.H. Bach, C. Ferran, M. Soares Modification of vascular responses in xenotransplantation inflammation and apoptosis Nat Med 3 1997 944 948
32. E. Bonfoco, D. Krainc, M. Ankarcrona, P. Nicotera, S.A. Lipton Apoptosis and necrosis two distinct events induced, respectively, by mild and intense insults with N-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures Proc Natl Acad Sci U S A 92 1995 7162 7166
33. P.A. Krijnen, R. Nijmeijer, C.J. Meijer, C.A. Visser, C.E. Hack, H.W. Niessen Apoptosis in myocardial ischaemia and infarction J Clin Pathol 55 2002 801 811