Mapping the binding site for gossypol-like inhibitors of Plasmodium falciparum lactate dehydrogenase

Molecular and Biochemical Parasitology

Volumn 142, Issue 2, 2005, Pages 137-148

  Conners, Rebecca ^a   Schambach, Felix ^a,c   Read, Jon ^a,d   Cameron, Angus ^a   Sessions, Richard B ^a   Vivas, Livia ^b   Easton, Anna ^b   Croft, Simon L ^b,e   Brady, R Leo ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d ASTRAZENECA   (United Kingdom)

^e Drugs for Neglected Diseases Initiative DNDi   (Switzerland)

Author keywords

Crystallography; Gossypol; Lactate dehydrogenase; Malaria; Naphthoic acids

Indexed keywords

1,6 DIBROMO 2 HYDROXYNAPHTHALENE 3 CARBOXYLIC ACID; 2,6 NAPHTHALENEDICARBOXYLIC ACID; 2,6 NAPHTHALENEDISULFONIC ACID; 3,5 DIHYDROXY 2 NAPHTHOIC ACID; 3,7 DIHYDROXY 2 NAPHTHOIC ACID; 3,7 DIHYDROXYNAPHTHALENE 2 CARBOXYLIC ACID; 6,6' DITHIODINICOTINIC ACID; 8 ANILINO 1 NAPHTHALENESULFONIC ACID; ANTIMALARIAL AGENT; CHLOROQUINE; GOSSYPOL; LACTATE DEHYDROGENASE; METHYL 2 OXAMOTO 5 CHLOROBENZOATE; NAPHTHALENE DERIVATIVE; NICOTINAMIDE; PYRUVIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG STRUCTURE; ENZYME INHIBITION; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANIMALS; ANTIMALARIALS; BINDING SITES; CRYSTALLOGRAPHY; ENZYME INHIBITORS; GOSSYPOL; L-LACTATE DEHYDROGENASE; MODELS, MOLECULAR; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM;

GOSSYPIUM HIRSUTUM; PLASMODIUM FALCIPARUM;

EID: 20644455534     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbiopara.2005.03.015     Document Type: Article

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