Decreased firing frequency of midbrain dopamine neurons in mice lacking mu opioid receptors

European Journal of Neuroscience

Volumn 21, Issue 10, 2005, Pages 2883-2886

  Mathon, Daniel S ^a,d   Ramakers, Geert M J ^a   Pintar, John E ^b   Marinelli, Michela ^c  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Addiction; Dopaminergic; Electrophysiology; Impulse activity; Reward

Indexed keywords

DOPAMINE; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOPAMINERGIC ACTIVITY; DOPAMINERGIC NERVE CELL; DRUG DEPENDENCE; KNOCKOUT MOUSE; MESENCEPHALON; MOUSE; NERVE CELL NETWORK; NEUROMODULATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REINFORCEMENT; SIGNAL TRANSDUCTION;

ACTION POTENTIALS; ANIMALS; CROSSES, GENETIC; DOPAMINE; MESENCEPHALON; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; REACTION TIME; RECEPTORS, OPIOID, MU;

EID: 20644444790     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2005.04123.x     Document Type: Article

References (34)

1. Becker, A., Grecksch, G., Kraus, J., Loh, H.H., Schroeder, H. & Hollt, V. (2002) Rewarding effects of ethanol and cocaine in mu opioid receptor-deficient mice. Naunyn Schmiedebergs Arch. Pharmacol., 365, 296-302.
2. Chefer, V.I., Kieffer, B.L. & Shippenberg, T.S. (2003) Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice. Eur. J. Neurosci., 18, 1915-1922.
3. Cooper, D.C. (2002) The significance of action potential bursting in the brain reward circuit. Neurochem. Int., 41, 333-340.
4. Cruz, H.G., Ivanova, T., Lunn, ML., Stoffel, M., Siesinger, P.A. & Luscher, C. (2004) Bi-directional effects of GABA (B) receptor agonists on the mesolimbic dopamine system. Nat. Neurosci., 7, 153-159.
5. Engberg, G., Kling-Petersen, T. & Nissbrandt, H. (1993) GABAB-receptor activation alters the firing pattern of dopamine neurons in the rat substantia nigra, Synapse, 15, 229-238.
6. Erhardt, S., Mathe, J.M., Chergui, K., Engberg, G. & Svensson, T.H. (2002) GABA (B) receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo. Naunyn Schmiedebergs Arch. Pharmacol., 365, 173-180.
7. Everitt, B.J. & Wolf, M.E. (2002) Psychomotor stimulant addiction: a neural systems perspective. J. Neurosci., 22, 3312-3320.
8. Floresco, S.B., West, A.R., Ash, B., Moore, H. & Grace, A.A. (2003) Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat. Neurosci., 6, 968-973.
9. Gerrits, M.A., Lesscher, H.B. & Van Ree, J.M. (2003) Drug dependence and the endogenous opioid system. Eur. Neuropsychopharmacol., 13, 424-434.
10. Gonon, F.G. (1988) Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience, 24, 19-28.
11. Grace, A.A. & Bunney, B.S. (1983) Intracellular and extracellular electrophysiology of nigral dopaminergic neurons - 1. Identification and characterization. Neuroscience, 10, 301-315.
12. Grace, A.A. & Bunney, B.S. (1984a) The control of firing pattern in nigral dopamine neurons: burst firing. J. Neurosci., 4. 2877-2890.
13. Grace, A.A. & Bunney, B.S. (1984b) The control of firing pattern in nigral dopamine neurons: single spike firing. J. Neurosci., 4. 2866-2876.
14. Gysling, K. & Wang, R.Y. (1983) Morphine-induced activation of A10 dopamine neurons in the rat. Brain Res., 277, 119-127.
15. Henry, D.J., Greene, M.A. & White, F.J. (1989) Electrophysiological effects of cocaine in the mesoaccumbens dopamine system: repeated administration. J. Pharmacol Exp. Ther., 251, 833-839.
16. Johnson, S.W. & North, R.A. (1992) Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J. Physiol. (Lond.), 450, 455-468.
17. Kieffer, B.L. & Gaveriaux-Ruff, C. (2002) Exploring the opioid system by gene knockout. Prog. Neurobiol., 66, 285-306.
18. Marinelli, M., Cooper, D.C., Baker, L.K. & White, F.J. (2003) Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior. Psychopharmacology (Berl), 168, 84-98.
19. Marinelli, M., Cooper, D.C. & White, F.J. (2001) Electrophysiological correlates of enhanced vulnerability to cocaine self-administration. Phenotypic differences in drug effects related to behavioral traits versus states. N. I. D. A. Res. Monogr. Rev., 181, 46-48.
20. Marinelli, M., Cooper, D.C. & White, F.J. (2002) A brief period of reduced food availability increases dopamine neuronal activity and enhances motivation to self-administer cocaine. Behav. Pharmacol., 12, S62.
21. Marinelli, M. & White, F.J. (2000) Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. J. Neurosci., 20, 8876-8885.
22. Mathon, D.S., Kamal, A., Smidt, M.P. & Ramakers, G.M. (2003) Modulation of cellular activity and synaptic transmission in the ventral tegmental area. Eur. J. Pharmacol, 480, 97-115.
23. Mathon, D.S., Lesscher, H.M., Gerrits, M.A., Kamal, A., Pintar, J.E., Schuller, A.G., Spruijt, B.M., Burbach, J.P., Smidt, M.P., van Ree, J.M. & Ramakers, G.M. (2005) Increased GABAergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in mu-opioid receptor knockout mice. Neuroscience, 130, 359-367.
24. Moore, H., Rose, H.J. & Grace, A.A. (2001) Chronic cold stress reduces the spontaneous activity of ventral tegmental dopamine neurons. Neuropsychopharmacology, 24, 410-419.
25. Overton, P.G. & Clark, D. (1997) Burst firing in midbrain dopaminergic neurons. Brain Res. Brain Res. Rev., 25, 312-334.
26. Paladini, C.A., Iribe, Y. & Tepper, J.M. (1999) GABAA receptor stimulation blocks NMDA-induced bursting of dopaminergic neurons in vitro by decreasing input resistance. Brain Res., 832, 145-151.
27. Paladini, C.A. & Tepper, J.M. (1999) GABA (A) and GABA (B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo. Synapse, 32, 165-176.
28. Schuller, A.G., King, M.A., Zhang, J., Bolan, E., Pan, Y.X., Morgan, D.J., Chang, A., Czick, M.E., Unterwald, E.M., Pasternak, G.W. & Pintar, J.E. (1999) Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat. Neurosci., 2, 151-156.
29. Schultz, W. (1998) Predictive reward signal of dopamine neurons. J. Neurophysiol., 80, 1-27.
30. Siesinger, P.A., Stoffel, M., Jan, Y.N. & Jan, L.Y. (1997) Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Proc. Natl. Acad. Sci. USA, 94, 12210-12217.
31. Ungless, M.A., Magill, P.J. & Bolam, J.P. (2004) Uniform inhibition of dopamine neurons in the ventral tegmental area by aversive stimuli. Science, 303, 2040-2042.
32. White, F.J. & Kalivas, P.W. (1998) Neuroadaptations involved in amphetamine and cocaine addiction. Drug Alcohol Depend., 51, 141-153.
33. Wise, R.A. (1998) Drug-activation of brain reward pathways. Drug Alcohol Depend., 51, 13-22.
34. Wise, R.A., Jenck, F., Gratton, A. & Quirion, R. (1986) Opiate receptor subtypes associated with the brain mechanisms of feeding and reward. NIDA Res. Monogr., 71, 165-172.