Counter-regulation of interleukin-1α (IL-1α) and IL-1 receptor antagonist in murine keratinocytes

Journal of Investigative Dermatology

Volumn 124, Issue 6, 2005, Pages 1267-1274

  Mee, John B ^a,d   Antonopoulos, Christos ^a   Poole, Stephen ^b   Kupper, Thomas S ^c   Groves, Richard W ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

^c Harvard Skin Disease Research Center   (United States)

^d ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Epidermis; IL 1; Inflammation

Indexed keywords

CYTOKINE; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; LIGAND; NEUTRALIZING ANTIBODY; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LINE; CELL STRAIN PAM212; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; EX VIVO STUDY; GENE OVEREXPRESSION; HOMEOSTASIS; IN VITRO STUDY; INFLAMMATION; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSGENIC MOUSE;

EID: 20544449842     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23684.x     Document Type: Article

References (50)

1. Ansel JC, Luger TA, Lowry D, Perry P, Roop DR, Mountz JD: The expression and modulation of IL-1α in murine keratinocytes. J Immunol 140:2274-2278, 1988
2. Arend WP, Guthridge CJ: Biological role of interleukin 1 receptor antagonist isoforms. Ann Rheum Dis 59 (Suppl. I):i60-i64, 2000
3. Arend WP, Malyak M, Smith MF, et al: Binding of IL-1α, IL-1β, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. J Immunol 153:4766-4774, 1994
4. Bigler CF, Norris DA, Weston WL, Arend WP: Interleukin-1 receptor antagonist production by human keratinocytes. J Invest Dermatol 98:38-44, 1992
5. Bresnihan B: Treatment of rheumatoid arthritis with interleukin 1 receptor antagonist. Ann Rheum Dis 584:196-198, 1999
6. Camp RDR, Fincham NJ, Ross J, Bird CR, Gearing AJH: Potent inflammatory properties in human skin of interleukin-1 alpha-like material isolated from normal skin. J Invest Dermatol 94:735-741, 1990
7. Colotta F, Re F, Muzio M, et al: Interleukin-1 type II receptor: A decoy target for IL-1 that is regulated by IL-4. Science 261:472-475, 1993
8. Cooper KD, Hammerberg C, Baadsgaard O, et al: IL-1 activity is reduced in psoriatic skin. Decreased IL-1α and increased nonfunctional IL-1β. J Immunol 144:4593-4603, 1990
9. Corradi A, Franzi AT, Rubartelli A: Synthesis and secretion of interleukin-1α and interleukin-1 receptor antagonist during differentiation of cultured keratinocytes. Exp Cell Res 217:355-362, 1995
10. Dinarello CA: Biologic basis for interleukin-1 in disease. Blood 87:2095-2147, 1996
11. Dinarello CA, Ikejima T, Warner SJC, Orencole SF, Lonnemann G, Cannon JG, Libby P: Interleukin 1 induces interleukin 1. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J Immunol 139:1902-1910, 1987
12. Dunn E, Sims JE, Nicklin MJH, O'Neill LAJ: Annotating genes with potential roles in the immune system: Six new members of the IL-1 family. Trends Immunol 22:533-536, 2001
13. Gabay C, Porter B, Fantuzzi G, Arend WP: Mouse IL-1 receptor antagonist isoforms: Complementary DNA cloning and protein expression of intracellular isoform and tissue distribution of secreted and intracellular IL-1 receptor antagonist in vivo. J Immunol 159:5905-5913, 1997
14. Garat C, Arend WP: Intracellular IL-1ra type I inhibits IL-1-induced IL-6 and IL-8 production in Caco-2 intestinal epithelial cells through inhibition of p38 mitogen-activated protein kinase and NF-κB pathways. Cytokine 23: 31-40, 2003
15. Granowitz EV, Clark BD, Vannier E, Callahan MV, Dinarello CA: Effect of interleukin-1 (IL-1) blockade on cytokine synthesis. 1. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human monocytes. Blood 79:2356-2363, 1992
16. Groves RW, Giri J, Sims JE, Dower SK, Kupper TS: Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1 mediated processes in epidermis. J Immunol 154:4065-4072, 1995a
17. Groves RW, Mizutani H, Kieffer JD, Kupper TS: Inflammatory skin disease in transgenic mice that express high levels of interleukin 1α in basal epidermis. Proc Natl Acad Sci USA 92:11874-11878, 1995b
18. Groves RW, Rauschmayr T, Nakamura K, Sarkar S, Williams IR, Kupper TS: Inflammatory and hyperproliferative skin disease in mice that express elevated levels of the IL-1 receptor (type I) on epidermal keratinocytes: Evidence that IL-1 inducible secondary cytokines produced by keratinocytes in vivo can cause skin disease. J Clin Invest 98:336-344, 1996
19. Groves RW, Ross E, Barker JNWN, Ross JS, Camp RDR, MacDonald DM: Effect of in vivo interleukin-1 on adhesion molecule expression in normal human skin. J Invest Dermatol 98:384-387, 1992
20. Groves RW, Sherman L, Mizutani H, Dower SK, Kupper TS: Detection of interleukin-1 receptors in human epidermis. Induction of the type II receptor after organ culture and in psoriasis. Am J Pathol 145:1048-1056, 1994
21. Hammerberg C, Arend WP, Fisher GJ, et al: Interleukin-1 receptor antagonist in normal and psoriatic epidermis. J Clin Invest 90:571-583, 1992
22. Higgins GC, Wu Y, Postlethwaite AE: Intracellular IL-1 receptor antagonist is elevated in human dermal fibroblasts that overexpress intracellular precursor IL-1α. J Immunol 163:3969-3975, 1999
23. Horai R, Asano M, Sudo K, et al: Production of mice deficient in genes for interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 receptor antagonist shows that IL-1β is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 187:1463-1475, 1998
24. Jenkins JK, Arend WP: Interleukin 1 receptor antagonist production in human monocytes is induced by IL-1α, IL-3, IL-4 and GM-CSF. Cytokine 5: 407-415, 1993
25. Kupper TS: Immune and inflammatory processes in cutaneous tissues: Mechanisms and speculations. J Clin Invest 86:1783-1789, 1990
26. Kupper TS, Ballard DW, Chua AO, et al: Human keratinocytes contain mRNA indistinguishable from monocyte interleukin 1α and β mRNA. J Exp Med 164:2095-2100, 1986
27. Kupper TS, Groves RW: The interleukin-1 axis and cutaneous inflammation. J Invest Dermatol 105:623-663, 1995
28. Kutsch CL, Norn's DA, Arend WP: Tumor necrosis factor-α induces interleukin-1α and interleukin-1 receptor antagonist production by cultured human keratinocytes. J Invest Dermatol 101:79-85, 1993
29. La E, Fischer SM: Transcriptional regulation of intracellular IL-1 receptor antagonist gene by IL-1α in primary mouse keratinocytes. J Immunol 166:6149-6155, 2001
30. La E, Muga SJ, Locniskar MF, Fischer SM: Altered expression of interleukin-1 receptor antagonist in different stages of mouse skin carcinogenesis. Mol Carcinog 24:276-286, 1999
31. La E, Rundhaug JE, Pavone A, Fischer SM: Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 in mouse carcinoma cells. Mol Carcinog 33:237-243, 2002
32. Labow M, Shuster D, Zetterstrom M, et al: Absence of IL-1 signaling and reduced inflammatory response in IL-1 type I receptor-deficient mice. J Immunol 159:2452-2461, 1997
33. Lee RT, Briggs WH, Cheng GC, Rossiter HB, Libby P, Kupper TS: Mechanical deformation promotes secretion of IL-1α and IL-1 receptor antagonist. J Immunol 159:5084-5088, 1997
34. Manson JC, di Giovine FS, Poole S, Duff GW: Autoregulation of interleukin-1 production. Eur J Immunol 19:261-265, 1989
35. McMahan CJ, Slack JL, Mosley B, et al: A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J 10:2821-2832, 1991
36. Mee JB, Alam Y, Groves RW: Human keratinocytes constitutively produce but do not process interleukin-18. Br J Dermatol 143:330-336, 2000
37. Miyazaki Y, Yokozeki H, Awad S, et al: Glucocorticoids augment the chemically induced production and gene expression of interleukin-1α through NF-κB and AP-1 activation in murine epidermal cells. J Invest Dermatol 115: 746-752, 2000
38. Mizutani H, Black RA, Kupper TS: Human keratinocytes produce but do not process pro-interleukin-1 (IL-1) beta. Different strategies of IL-1 production and processing in monocytes and keratinocytes. J Clin Invest 87:1066-1071, 1991
39. Netea MG, Kullberg BJ, Boerman OC, Verschueren I, Dinarello CA, Van der Meer JWM: Soluble murine IL-1 receptor type I induces release of constitutive IL-1α. J Immunol 162:4876-4881, 1999
40. Nicklin MJH, Hughes DE, Barton JL, Ure JM, Duff GW: Arterial inflammation in mice lacking the interleukin 1 receptor antagonist gene. J Exp Med 191:303-311, 2000
41. Nicklin MJH, Weith A, Duff GW: A physical map of the region encompassing the human interleukin-1α, interleukin-1β and interleukin-1 receptor antagonist genes. Genomics 19:382-384, 1994
42. Rauschmayr T, Groves RW, Kupper TS: Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation. Proc Natl Acad Sci USA 94:5814-5819, 1997
43. Shepherd J, Little MC, Nicklin MJH: Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist. J Invest Dermatol 122: 665-669, 2004
44. Sims JE, Acres RB, Grubin CE, McMahan CJ, Wignall JM, March CJ, Dower SK: Cloning the interleukin 1 receptor from human T cells. Proc Natl Acad Sci USA 86:8946-8950, 1989
45. Singer II, Scott S, Chin J, et al: The interleukin-1β-converting enzyme (ICE) is localised on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J Exp Med 182:1447-1459, 1995
46. Szabowski A, Maas-Szabowski N, Andrecht S, Kolbus A, Schorpp-Kistner M, Fusenig NE, Angel P: c-Jun and JunB antagonistically control cytokine-mediated mesenchymal-epidermal interaction in skin. Cell 103:745-755, 2000
47. Terui T, Hirao T, Sato Y, et al: An increased ratio of interleukin-1 receptor antagonist to interleukin-1 alpha in inflammatory skin diseases. Exp Dermatol 7:327-334, 1998
48. Towne JE, Garka KE, Renshaw BR, Virca GD, Sims JE: Interleukin (IL)-1F6, IL-1F8, and 1L-1F9 signal through IL-1Rrp2 and IL-IRAcP to activate the pathway leading to NF-κB and MAPKs. J Biol Chem 279:13677-13688, 2004
49. Watson JM, Lofquist AK, Rinehart CA, Olsen JC, Makarov SS, Kaufman DG, Haskill JS: The intracellular IL-1 receptor antagonist alters IL-1-inducible gene expression without blocking exogenous signaling by IL-1β. J Immunol 155:4467-4475, 1995
50. Zahedi K, Seldin MF, Rits M, Ezekowitz RAB, Whitehead AS: Mouse IL-1 receptor antagonist protein. Molecular characterization, gene mapping, and expression of mRNA in vitro and In vivo. J Immunol 146:4228-4233, 1991