Decreased agonist, but not antagonist, binding to the naturally occurring Thr92Lys variant of the h5-HT7(a) receptor

Neurochemistry International

Volumn 47, Issue 3, 2005, Pages 196-203

  Brüss, Michael ^a   Kiel, Sibylle ^a   Bönisch, Heinz ^a   Kostanian, Arevat ^a   Göthert, Manfred ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

(Thr92Lys) h5 HT7(a) receptor; 3H 5 CT binding; cAMP formation; HEK293 cells; Pharmacogenetic differences

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 5 CARBAMOYLTRYPTAMINE; 5 METHOXY 3 (1,2,3,6 TETRAHYDRO 4 PYRIDYL) 1H INDOLE; CLOZAPINE; CYCLIC AMP; LYSINE; SEROTONIN; SUMATRIPTAN; THREONINE; TRITIUM;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL STRAIN HEK293; CIRCADIAN RHYTHM; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

AMINO ACID SUBSTITUTION; BINDING SITES; BINDING, COMPETITIVE; BRAIN; BRAIN CHEMISTRY; CELL LINE; CELL MEMBRANE; CHRONOBIOLOGY DISORDERS; CYCLIC AMP; DOWN-REGULATION; HUMANS; LYSINE; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; THREONINE; VARIATION (GENETICS);

EID: 20544442870     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.03.003     Document Type: Article

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