Tumor-specific gene delivery using RNA-targeting Tetrahymena group I intron

Biotechnology Letters

Volumn 27, Issue 8, 2005, Pages 567-574

  Jung, Heung Su ^a   Kwon, Byung Su ^a   Lee, Seong Wook ^a  

^a Dankook University   (South Korea)

Author keywords

Cancer gene therapy; Gene delivery; Specific targeting; Tetrahymena group I intron; trans splicing ribozyme

Indexed keywords

CELLS; COENZYMES; GENETIC ENGINEERING; RNA; TUMORS;

CANCER CELLS; GENE DELIVERY; GENE THERAPY; RIBOZYME;

GENES;

COMPLEMENTARY DNA; DNA BINDING PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MESSENGER RNA; RIBOZYME; RNA; TELOMERASE;

ANIMAL; ARTICLE; CELL LINE; CELL STRAIN HT29; CELL SURVIVAL; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC TRANSFECTION; GENETICS; HUMAN; INTRON; METABOLISM; METHODOLOGY; NUCLEOTIDE SEQUENCE; PLASMID; TETRAHYMENA; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DNA, ANTISENSE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE TARGETING; GREEN FLUORESCENT PROTEINS; HT29 CELLS; HUMANS; INTRONS; PLASMIDS; RECOMBINANT FUSION PROTEINS; RNA, CATALYTIC; RNA, MESSENGER; RNA, NEOPLASM; TELOMERASE; TETRAHYMENA; TRANSFECTION;

TETRAHYMENA;

EID: 20544439120     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10529-005-2883-6     Document Type: Article

References (12)

1. AG Bodnar M Ouellette M Frolkis SE Holt CP Chiu GB Morin CB Harley JW Shay S Lichtsteiner WE Wright 1998 Extension of life-span by introduction of telomerase into normal human cells Science 279 349 352
2. J Byun N Lan M Long BA Sullenger 2003 Efficient and specific repair of sickle beta-globin RNA by trans-splicing ribozymes RNA 9 1254 1263
3. U Kohler BG Ayre HM Goodman J Haseloff 1999 Trans-splicing ribozymes for targeted gene delivery J. Mol. Biol. 185 1935 1950
4. N Lan RP Howrey SW Lee CA Smith BA Sullenger 1998 Ribozyme-mediated repair of sickle β-globin mRNAs in erythrocyte precursors Science 280 1593 1596
5. F McCormick 2001 Cancer gene therapy: fringe or cutting edge? Nat. Rev. Cancer 1 130 141
6. M Meyerson CM Counter N Eaton LW Ellisen P Steiner SD Caddle L Ziaugra RL Beijersbergen MJ Davidoff Q Liu S Bacchetti DA Haber RA Weinberg 1997 hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization Cell 90 785 795
7. LA Phylactou C Darrah MAJ Wood 1998 Ribozyme- mediated trans-splicing of a trinucleotide repeat Nat. Genet. 18 378 381
8. CS Rogers CG Vanoye BA Sullenger AL George 2002 Functional repair of a mutant chloride channel using a trans-splicing ribozyme J. Clin. Invest. 110 1783 1798
9. KJ Ryu JH Kim SW Lee 2003 Ribozyme-mediated selective induction of new gene activity in hepatitis C virus internal ribosome entry site-expressing cells by targeted trans-splicing Mol. Ther. 7 386 395
10. KS Shin BA Sullenger SW Lee 2004 Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA Mol. Ther. 10 365 372
11. RL Strausberg AJ Simpson LJ Old GJ Riggins 2004 Oncogenomics and the development of new cancer therapies Nature 429 469 474
12. BA Sullenger TR Cech 1994 Ribozyme-mediated repair of defective mRNA by targeted trans-splicing Nature 317 619 622